iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
iRefIndex	Mentha
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
UniProt	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.10e-09	40.1	30	150

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees......................................................k 38
           +Dv+l+ g+++f+ah++vLaasS++F+  +l+  +                                                         
   Q: 30   CDVTLIAGDTKFPAHRSVLAASSPFFREALLTSAPLPlppatggaapnpatttaassssssssssssssssasssssssssspppasppasS 121
           9*****************************999995569***************************************************76 PP
   S: 39   sklmveikdvqpevfrallkFlYtgklde 67
           +    e+ +v + +f+++l+F+Y+ +l +
   Q: 122  PPRVLELPGVPAAAFSDVLNFIYSARLAL 150
           56677888****************99975 PP

Organism

Homo sapiens

Functional Description
(View)

Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688).

Protein Sequence
(Fasta)

MPPPAEVTDP SHAPAVLRQL NEQRLRGLFC DVTLIAGDTK FPAHRSVLAA SSPFFREALL 60
TSAPLPLPPA TGGAAPNPAT TTAASSSSSS SSSSSSSSSS ASSSSSSSSS SPPPASPPAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGGGGTGCG AGCCAGAGTC GTGGGTAAAC CCCCCGCTCG CTGGTTGGGC GACCTTTTGA 60
AGTGACAGGG AGAGAAGAAT TTTTTTCTTT AATCCCACCG CCTCTCCTCG CTGCTCCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0008327--F:methyl-CpG binding
GO:0010428--F:methyl-CpNpG binding
GO:0042803--F:protein homodimerization activity
GO:0019901--F:protein kinase binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:57659

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004385	Anolis carolinensis	42.53	1.00e-153	537.00
IUUC-Bta-012689	Bos taurus	84.86	0.00e+00	1077.00
IUUC-Cja-019922	Callithrix jacchus	93.60	0.00e+00	951.00
IUUC-Cfa-020348	Canis familiaris	86.82	0.00e+00	1037.00
IUUC-Cpo-021824	Cavia porcellus	80.08	0.00e+00	1095.00
IUUC-Csa-024023	Chlorocebus sabaeus	97.19	0.00e+00	1045.00
IUUC-Dno-029721	Dasypus novemcinctus	86.57	0.00e+00	1070.00
IUUC-Dor-030987	Dipodomys ordii	82.99	1.00e-168	587.00
IUUC-Ete-032788	Echinops telfairi	82.37	0.00e+00	631.00
IUUC-Eca-034199	Equus caballus	90.22	0.00e+00	1032.00
IUUC-Eeu-034887	Erinaceus europaeus	85.04	2.00e-133	470.00
IUUC-Fca-036123	Felis catus	93.56	3.00e-141	495.00
IUUC-Ggo-044792	Gorilla gorilla	98.76	0.00e+00	1092.00
IUUC-Itr-048293	Ictidomys tridecemlineatus	91.24	0.00e+00	1024.00
IUUC-Lch-049633	Latimeria chalumnae	41.94	3.00e-147	516.00
IUUC-Laf-053666	Loxodonta africana	84.94	0.00e+00	1056.00
IUUC-Mcc-055380	Macaca mulatta	97.53	0.00e+00	1044.00
IUUC-Meu-056434	Macropus eugenii	67.04	0.00e+00	735.00
IUUC-Mdo-062151	Monodelphis domestica	73.48	6.00e-139	487.00
IUUC-Mmu-064025	Mus musculus	85.12	4.00e-172	598.00
IUUC-Mpu-065808	Mustela putorius furo	83.66	0.00e+00	1034.00
IUUC-Mlu-068025	Myotis lucifugus	86.18	0.00e+00	1115.00
IUUC-Opr-070749	Ochotona princeps	84.19	0.00e+00	899.00
IUUC-Ocu-074809	Oryctolagus cuniculus	87.78	0.00e+00	932.00
IUUC-Oga-088975	Otolemur garnettii	86.67	0.00e+00	1118.00
IUUC-Oar-090000	Ovis aries	80.67	2.00e-140	493.00
IUUC-Ptr-090835	Pan troglodytes	98.31	0.00e+00	1069.00
IUUC-Pan-092409	Papio anubis	97.53	0.00e+00	1050.00
IUUC-Pab-097964	Pongo abelii	97.30	0.00e+00	1025.00
IUUC-Pca-100651	Procavia capensis	79.70	0.00e+00	966.00
IUUC-Pva-102379	Pteropus vampyrus	87.07	0.00e+00	1010.00
IUUC-Rno-104928	Rattus norvegicus	84.50	9.00e-176	610.00
IUUC-Sha-106756	Sarcophilus harrisii	64.65	0.00e+00	732.00
IUUC-Sar-113009	Sorex araneus	83.11	0.00e+00	966.00
IUUC-Ssc-115587	Sus scrofa	85.15	0.00e+00	1009.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence