iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091656

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin specific peptidase 18

Genbank Nucleotide ID

AACZ03126737

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000014048.4	ENSPTRT00000026239.4	ENSPTRP00000024196.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.80e-59	200.0	55	370

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+N+g tC +NS++Q+ ++  ++++ l++    ++++ + +e+  ++  ++  l+e++++s++kav p el  +l+k+++    + q
   Q: 55   VGLHNIGQTCCLNSLIQVFVMNVDFTRILKR---ITVPRGA-DEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKYNVP--LFVQ 137
           6******************************...5555443.567889*********************************99..79** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da  +   l + +++++                           + +  + ++dl+ +++k++++c +c+ +ssr++++l+l+l++ +
   Q: 138  HDAAQLYLKLWNLIKDQI--------------------------ADVHLVERLQDLYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFD 200
           ******************..........................56778899************************************* PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls..... 262
            +++ +++l+d+L+ f+++ el ++ k++ce+c kk++ ++ lkl++lP++L++hL+Rfs ++  ++ +ki  +++fp++Ld s     
   Q: 201  VDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRN--SQTRKICHSLYFPQSLDFSqilpm 287
           **999******************************************************7755..6888***************55532 PP
   S: 263  ..pfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkrr 338
             + c     +++++ +YeL+av+ H G ++sGHY++y++n  +gkW++f+Ds++  v++e+++ + g       +taY+l+Y+++
   Q: 288  krESCDA---EEQSRGQYELFAVIAHVGMADSGHYCVYIRNaVDGKWFCFNDSNICLVSWEDIQCTYGnpnyhwqETAYLLVYMKM 370
           2112222...223389*************************55777*******************888***************986 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSKAFGLLRQ ICQSILAESS QSPADLEEKK EEDSNMKREQ PRERPRAWDY PHGLVGLHNI 60
GQTCCLNSLI QVFVMNVDFT RILKRITVPR GADEQRRSVP FQMLLLLEKM QDSRQKAVRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGATCACGAA TGAGCAAGGC GTTTGGTCTC CTGAGACAAA TCTGTCAGTC CATCCTGGCT 60
GAGTCCTCGC AGTCCCCGGC AGATCTTGAA GAAAAGAAGG AAGAAGACAG CAACATGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	76.40	6.00e-159	553.00
IUUC-Apl-004006	Anas platyrhynchos	57.19	5.00e-107	380.00
IUUC-Aca-005088	Anolis carolinensis	55.08	7.00e-93	333.00
IUUC-Ame-010606	Astyanax mexicanus	32.28	6.00e-38	151.00
IUUC-Bta-013036	Bos taurus	75.55	1.00e-147	515.00
IUUC-Cja-019052	Callithrix jacchus	83.59	2.00e-158	551.00
IUUC-Cfa-020554	Canis familiaris	80.60	2.00e-164	571.00
IUUC-Cpo-022421	Cavia porcellus	72.27	1.00e-160	559.00
IUUC-Csa-023737	Chlorocebus sabaeus	93.10	2.00e-115	407.00
IUUC-Cho-024807	Choloepus hoffmanni	68.37	1.00e-68	253.00
IUUC-Dre-027408	Danio rerio	31.66	1.00e-43	170.00
IUUC-Dno-029813	Dasypus novemcinctus	65.77	2.00e-126	444.00
IUUC-Dor-030532	Dipodomys ordii	71.93	3.00e-159	554.00
IUUC-Ete-032254	Echinops telfairi	68.46	2.00e-154	538.00
IUUC-Eca-033482	Equus caballus	80.88	2.00e-158	551.00
IUUC-Eeu-034451	Erinaceus europaeus	71.56	2.00e-91	327.00
IUUC-Fca-036313	Felis catus	76.82	7.00e-165	572.00
IUUC-Fal-037216	Ficedula albicollis	53.22	1.00e-107	383.00
IUUC-Gmo-038649	Gadus morhua	32.70	4.00e-40	158.00
IUUC-Gga-041082	Gallus gallus	55.56	2.00e-96	345.00
IUUC-Gac-042439	Gasterosteus aculeatus	35.56	1.00e-50	193.00
IUUC-Ggo-044957	Gorilla gorilla	97.07	4.00e-160	556.00
IUUC-Hsa-046381	Homo sapiens	98.92	0.00e+00	766.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	77.36	8.00e-172	595.00
IUUC-Loc-052688	Lepisosteus oculatus	33.85	2.00e-48	185.00
IUUC-Laf-054109	Loxodonta africana	77.48	3.00e-179	620.00
IUUC-Mcc-054814	Macaca mulatta	92.25	0.00e+00	724.00
IUUC-Meu-056253	Macropus eugenii	66.43	7.00e-108	383.00
IUUC-Mmr-061613	Microcebus murinus	81.19	2.00e-165	574.00
IUUC-Mdo-061890	Monodelphis domestica	62.80	1.00e-119	422.00
IUUC-Mmu-064329	Mus musculus	70.62	4.00e-148	517.00
IUUC-Mpu-066342	Mustela putorius furo	77.38	6.00e-168	583.00
IUUC-Mlu-067010	Myotis lucifugus	77.20	3.00e-169	587.00
IUUC-Nle-069148	Nomascus leucogenys	94.62	0.00e+00	737.00
IUUC-Opr-070988	Ochotona princeps	71.97	5.00e-67	247.00
IUUC-Ont-072039	Oreochromis niloticus	34.38	9.00e-49	187.00
IUUC-Oan-073740	Ornithorhynchus anatinus	57.35	2.00e-76	278.00
IUUC-Ocu-074498	Oryctolagus cuniculus	75.07	6.00e-155	540.00
IUUC-Ola-086753	Oryzias latipes	35.67	1.00e-48	186.00
IUUC-Oga-088497	Otolemur garnettii	79.11	2.00e-171	594.00
IUUC-Oar-089505	Ovis aries	75.24	3.00e-147	514.00
IUUC-Pan-092498	Papio anubis	91.98	0.00e+00	719.00
IUUC-Psi-093409	Pelodiscus sinensis	55.43	7.00e-112	397.00
IUUC-Pfo-096507	Poecilia formosa	34.29	4.00e-47	181.00
IUUC-Pab-097828	Pongo abelii	93.81	0.00e+00	632.00
IUUC-Pca-100299	Procavia capensis	74.69	3.00e-103	368.00
IUUC-Pva-102972	Pteropus vampyrus	76.69	6.00e-163	566.00
IUUC-Rno-105738	Rattus norvegicus	70.89	1.00e-155	542.00
IUUC-Sha-107309	Sarcophilus harrisii	61.68	2.00e-113	402.00
IUUC-Sar-112983	Sorex araneus	73.43	5.00e-120	424.00
IUUC-Ssc-116049	Sus scrofa	76.49	1.00e-151	528.00
IUUC-Tgu-117115	Taeniopygia guttata	56.33	8.00e-105	373.00
IUUC-Tru-118022	Takifugu rubripes	31.45	3.00e-40	158.00
IUUC-Tsy-118986	Tarsius syrichta	61.61	4.00e-63	234.00
IUUC-Tni-120306	Tetraodon nigroviridis	31.65	2.00e-39	156.00
IUUC-Tbe-127768	Tupaia belangeri	68.79	1.00e-116	412.00
IUUC-Ttr-128686	Tursiops truncatus	74.42	1.00e-151	528.00
IUUC-Xtr-132032	Xenopus tropicalis	42.45	3.00e-69	254.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence