iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000036805.13	ENSMUST00000114373.7	ENSMUSP00000110014.1
ENSMUSG00000036805.13	ENSMUST00000044018.7	ENSMUSP00000037423.7

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-11	45.5	371	425

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +++v ++y+y aq  ++L +++Gd+v+v+   e de Wl+g  +  g+ G+fP+ Fv+ 
   Q: 371  LYQVVAQYNYRAQRPEDLDFHQGDTVDVL--CEVDEAWLEG--HRDGCVGIFPKCFVVP 425
           6899*************************..9*********..89***********986 PP

Organism

Mus musculus

Functional Description
(View)

Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Protein Sequence
(Fasta)

MSSLGDQIRD WHRGVLAVAR EDWDSALCFF SDVREPLARM YFNRGCVHLM AGDPEAALRA 60
FDQAVTKDTC MAVGFLQRGV ANFQLQRFQE AVSDFQLALA QLRDNAVIDY TQLGLNFKLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGGGCGT GAGAGAGGGG CCTAAGCCTT GGGCCATCTA CTCAGTTTCA AGGACCGACT 60
GTCACAACTC CAGTTGTCTT GCTACCAGCT GCTTCTCATT GCTGTCCCGG TCCCCTTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0802--TPR repeat

Interpro

IPR000270--PB1_dom
IPR001452--SH3_domain
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat

PROSITE

PS51745--PB1
PS50002--SH3
PS50005--TPR
PS50293--TPR_REGION

Pfam

PF00564--PB1
PF00018--SH3_1

SMART

SM00666--PB1
SM00326--SH3
SM00028--TPR

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043020--C:NADPH oxidase complex
GO:0019899--F:enzyme binding
GO:0048365--F:Rac GTPase binding
GO:0017124--F:SH3 domain binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0010310--P:regulation of hydrogen peroxide metabolic process
GO:0060263--P:regulation of respiratory burst
GO:0006801--P:superoxide metabolic process

KEGG

mmu:241275

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013236	Bos taurus	70.14	8.00e-86	310.00
IUUC-Cpo-022423	Cavia porcellus	57.99	3.00e-136	478.00
IUUC-Csa-023576	Chlorocebus sabaeus	70.72	2.00e-86	313.00
IUUC-Eca-033997	Equus caballus	60.00	2.00e-146	512.00
IUUC-Eeu-035239	Erinaceus europaeus	62.75	2.00e-68	253.00
IUUC-Itr-048999	Ictidomys tridecemlineatus	61.35	6.00e-137	480.00
IUUC-Mcc-055758	Macaca mulatta	70.27	7.00e-86	311.00
IUUC-Mdo-062802	Monodelphis domestica	48.37	4.00e-111	394.00
IUUC-Oga-088950	Otolemur garnettii	65.89	3.00e-160	558.00
IUUC-Oar-089752	Ovis aries	66.34	2.00e-69	256.00
IUUC-Pan-092537	Papio anubis	70.72	8.00e-86	310.00
IUUC-Pva-103116	Pteropus vampyrus	55.70	2.00e-120	426.00
IUUC-Rno-105888	Rattus norvegicus	86.32	0.00e+00	761.00
IUUC-Sha-107541	Sarcophilus harrisii	43.74	5.00e-102	364.00
IUUC-Ssc-115353	Sus scrofa	58.75	3.00e-149	521.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence