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Tag Content
UUCD2 ID IUUC-Bta-012600
UUCD1 version UUC-BoT-00346
Ensembl Protein ID ENSBTAP00000042353.3
UniProt Accession A7E320; F1MY11; UHRF1_BOVIN
Genbank Protein ID AAI51672.1
Protein Name E3 ubiquitin-protein ligase UHRF1; RING-type E3 ubiquitin transferase UHRF1; Ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 1
Genbank Nucleotide ID DAAA02019593
Gene Name UHRF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000002224.5 ENSBTAT00000044908.3 ENSBTAP00000042353.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.20e-08 34.3 321 368
ULD/UDP/UBQ/UBQ_Other 1.40e-15 57.1 1 76
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
            C+vCg +++ +k  ++C++C+ +fH  Cl ++  +++p +e+w+Cp+Cr
   Q: 321  ACHVCGGKQDPDK-QLMCDECDMAFHIYCLRPP-LSSVPPEEEWYCPDCR 368
           5********9997.556****************.999999999******7 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 1    vqvtvksldgs.eltlk.vnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
           ++++v+++dg+  +t+  +++ + V eL++ki++++++ p  qrL y+Gk +ed++tL dy+++ ++ti ll+++s
   Q: 1    MWIQVRTMDGKvAHTVDsLSRLTKVEELRKKIQELFHVEPGLQRLFYRGKQMEDGHTLFDYDVRLNDTIQLLVRQS 76
           789*************9*******************************************************9986 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair (By similarity).
 Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair (By similarity).
Protein Sequence
(Fasta)
MWIQVRTMDG KVAHTVDSLS RLTKVEELRK KIQELFHVEP GLQRLFYRGK QMEDGHTLFD 60
YDVRLNDTIQ LLVRQSLVLP VPVPSSSGGS KERDSELSDT DSGCGLAQSE SDKSSNSGEA 120
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Protein Fasta Sequence


>IUUC-Bta-012600|E3,PHD;ULD,UBQ_Other|Bos taurus
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Nucleotide Sequence
(Fasta)
GCTCGCTGGC GTGGCCCGCG CGGGCGAGCG AGAGAACAAG AGGGGCTACG GGGCCGTGCG 60
TCTGGGTCCG GGAAACGCAG GCTGGAGCTC CGGGCGGCCG TGGGGCAGAA GTGAGTAGCG 120
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Nucleotide Fasta Sequence


>IUUC-Bta-012600|E3,PHD;ULD,UBQ_Other|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015947--PUA-like_domain
IPR014722--Rib_L2_dom2
IPR003105--SRA_YDG
IPR021991--TTD_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50053--UBIQUITIN_2
PS51015--YDG
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00628--PHD
PF02182--SAD_SRA
PF12148--TTD
PF00240--ubiquitin
SMART

SM00249--PHD
SM00184--RING
SM00466--SRA
SM00213--UBQ
Gene Ontology

GO:0000791--C:euchromatin
GO:0000792--C:heterochromatin
GO:0000790--C:nuclear chromatin
GO:0005720--C:nuclear heterochromatin
GO:0016363--C:nuclear matrix
GO:0005657--C:replication fork
GO:0044729--F:hemi-methylated DNA-binding
GO:0042393--F:histone binding
GO:0035064--F:methylated histone binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0006281--P:DNA repair
GO:0010390--P:histone monoubiquitination
GO:0016574--P:histone ubiquitination
GO:0010216--P:maintenance of DNA methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090308--P:regulation of methylation-dependent chromatin silencing
GO:0006351--P:transcription, DNA-templated
KEGG bta:530411
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001285 Ailuropoda melanoleuca 84.88 0.00e+00 1301.00
IUUC-Atr-002603 Amborella trichopoda 45.45 7.00e-44 172.00
IUUC-Apl-003819 Anas platyrhynchos 72.70 0.00e+00 1100.00
IUUC-Aly-006276 Arabidopsis lyrata 36.30 2.00e-51 197.00
IUUC-Ath-006667 Arabidopsis thaliana 34.13 3.00e-48 186.00
IUUC-Ame-011845 Astyanax mexicanus 67.75 0.00e+00 1032.00
IUUC-Bci-013703 Botrytis cinerea 30.95 4.00e-11 62.80
IUUC-Bol-015519 Brassica oleracea 35.41 1.00e-48 187.00
IUUC-Bra-017110 Brassica rapa 35.65 5.00e-49 189.00
IUUC-Cja-018864 Callithrix jacchus 81.22 0.00e+00 1268.00
IUUC-Cfa-020558 Canis familiaris 85.96 0.00e+00 1306.00
IUUC-Cpo-022125 Cavia porcellus 79.30 0.00e+00 1249.00
IUUC-Cre-022645 Chlamydomonas reinhardtii 32.68 2.00e-20 94.00
IUUC-Csa-023649 Chlorocebus sabaeus 79.48 0.00e+00 1238.00
IUUC-Cin-025454 Ciona intestinalis 52.65 0.00e+00 749.00
IUUC-Cgl-026498 Colletotrichum gloeosporioides 33.57 1.00e-11 64.30
IUUC-Cne-026942 Cryptococcus neoformans 43.90 8.00e-28 115.00
IUUC-Dre-028200 Danio rerio 67.29 0.00e+00 1063.00
IUUC-Dno-029523 Dasypus novemcinctus 84.72 0.00e+00 956.00
IUUC-Dor-031084 Dipodomys ordii 78.54 0.00e+00 1247.00
IUUC-Eca-033266 Equus caballus 83.38 0.00e+00 1264.00
IUUC-Eeu-035077 Erinaceus europaeus 86.91 2.00e-151 528.00
IUUC-Fca-035685 Felis catus 76.43 0.00e+00 1156.00
IUUC-Fal-037550 Ficedula albicollis 72.27 0.00e+00 1047.00
IUUC-Gmo-039452 Gadus morhua 64.91 0.00e+00 1034.00
IUUC-Ggr-039874 Gaeumannomyces graminis 29.94 3.00e-10 59.70
IUUC-Gga-040484 Gallus gallus 72.43 0.00e+00 1176.00
IUUC-Gac-042196 Gasterosteus aculeatus 64.12 0.00e+00 1023.00
IUUC-Gma-044194 Glycine max 34.20 2.00e-49 190.00
IUUC-Ggo-045414 Gorilla gorilla 82.79 0.00e+00 1298.00
IUUC-Hsa-046236 Homo sapiens 82.79 0.00e+00 1298.00
IUUC-Itr-047867 Ictidomys tridecemlineatus 76.88 0.00e+00 1201.00
IUUC-Lch-050162 Latimeria chalumnae 64.04 0.00e+00 989.00
IUUC-Loc-051806 Lepisosteus oculatus 67.79 0.00e+00 1082.00
IUUC-Lma-052953 Leptosphaeria maculans 25.85 5.00e-11 62.40
IUUC-Laf-053671 Loxodonta africana 80.67 0.00e+00 1263.00
IUUC-Mcc-055513 Macaca mulatta 82.34 0.00e+00 1297.00
IUUC-Mpo-057318 Magnaporthe poae 31.14 2.00e-10 60.10
IUUC-Mtr-057930 Medicago truncatula 33.41 7.00e-49 188.00
IUUC-Mla-058836 Melampsora laricipopulina 43.78 7.00e-34 138.00
IUUC-Mga-059759 Meleagris gallopavo 71.30 0.00e+00 1068.00
IUUC-Mvi-060378 Microbotryum violaceum 44.00 8.00e-33 134.00
IUUC-Mmr-060600 Microcebus murinus 73.26 0.00e+00 1082.00
IUUC-Mdo-061911 Monodelphis domestica 74.22 0.00e+00 1160.00
IUUC-Mmu-063738 Mus musculus 71.84 0.00e+00 1129.00
IUUC-Mac-065630 Musa acuminata 35.98 5.00e-45 176.00
IUUC-Mpu-065696 Mustela putorius furo 84.07 0.00e+00 1282.00
IUUC-Mlu-067538 Myotis lucifugus 78.22 0.00e+00 1202.00
IUUC-Opr-070813 Ochotona princeps 70.36 4.00e-171 594.00
IUUC-Ont-072292 Oreochromis niloticus 65.37 0.00e+00 1023.00
IUUC-Ola-086416 Oryzias latipes 64.30 0.00e+00 1015.00
IUUC-Oga-088221 Otolemur garnettii 81.42 0.00e+00 1290.00
IUUC-Oar-089604 Ovis aries 94.78 0.00e+00 1369.00
IUUC-Ptr-090559 Pan troglodytes 82.52 0.00e+00 1297.00
IUUC-Pan-092855 Papio anubis 82.34 0.00e+00 1297.00
IUUC-Psi-093763 Pelodiscus sinensis 74.08 0.00e+00 833.00
IUUC-Pma-094339 Petromyzon marinus 64.19 0.00e+00 937.00
IUUC-Ppa-095940 Physcomitrella patens 36.62 8.00e-50 192.00
IUUC-Pfo-096243 Poecilia formosa 63.08 0.00e+00 1004.00
IUUC-Pab-098243 Pongo abelii 82.79 0.00e+00 1278.00
IUUC-Pop-099561 Populus trichocarpa 35.42 3.00e-53 203.00
IUUC-Pca-100503 Procavia capensis 76.46 0.00e+00 1175.00
IUUC-Pva-102240 Pteropus vampyrus 82.19 0.00e+00 1039.00
IUUC-Pgr-103644 Puccinia graminis 41.40 2.00e-33 137.00
IUUC-Ptt-103867 Puccinia triticina 45.95 1.00e-34 141.00
IUUC-Rno-105345 Rattus norvegicus 72.40 0.00e+00 1143.00
IUUC-Sha-106618 Sarcophilus harrisii 74.44 0.00e+00 1157.00
IUUC-Smo-109556 Selaginella moellendorffii 37.22 3.00e-45 176.00
IUUC-Sly-111415 Solanum lycopersicum 34.86 4.00e-52 199.00
IUUC-Stu-112842 Solanum tuberosum 34.86 3.00e-51 196.00
IUUC-Sar-113651 Sorex araneus 70.16 8.00e-84 304.00
IUUC-Sre-115182 Sporisorium reilianum 46.20 1.00e-33 137.00
IUUC-Ssc-116081 Sus scrofa 85.84 0.00e+00 1347.00
IUUC-Tgu-116538 Taeniopygia guttata 74.96 0.00e+00 957.00
IUUC-Tru-117599 Takifugu rubripes 63.18 0.00e+00 986.00
IUUC-Tca-121614 Theobroma cacao 44.35 1.00e-45 177.00
IUUC-Tme-127149 Tuber melanosporum 47.98 6.00e-27 115.00
IUUC-Ttr-128522 Tursiops truncatus 91.45 0.00e+00 1387.00
IUUC-Vda-129727 Verticillium dahliae 27.95 1.00e-07 50.40
IUUC-Vvi-131413 Vitis vinifera 35.58 6.00e-50 192.00
IUUC-Xtr-132432 Xenopus tropicalis 67.58 0.00e+00 1089.00
IUUC-Xma-133516 Xiphophorus maculatus 64.40 0.00e+00 1028.00
IUUC-Zma-135894 Zea mays 35.98 2.00e-45 177.00
Created Date 25-Jun-2017

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