iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105382

Ensembl Protein ID

ENSRNOP00000047632.5

UniProt Accession

F1LRR4; F1LRR4_RAT

Genbank Protein ID

ENSRNOP00000047632

Protein Name

WD repeat domain 62

Genbank Nucleotide ID

AABR07002973

Gene Name

Wdr62

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000049708.2	ENSRNOT00000047120.5	ENSRNOP00000047632.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-25	88.6	425	450
UBD/Beta-Prp	3.70e-49	167.9	492	745

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 12   sdtllvsGsdDgtikvWDlrtgvllk 37
           ++++++++s D+ti+ W++++g +++
   Q: 425  PSGTFLTCSSDNTIRFWNMDSGSDTQ 450
           55789***************998875 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk...ilvtgseDrtikvwdls.tgkcvhtlkgh 93
           +k+ ++++++spd+++la+g r+g +++++++ ++ l +++ h+aev ++++s+ +    +l+++s+Dr+i+v +++ ++   +tl  h
   Q: 492  MKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKPETgvtLLASASRDRLIHVLNVEkNYNLEQTLDDH 580
           667788999999******************99999999999********9999887788999999*******9999977888899999* PP
   S: 94   edsvlslsfspsg.dklvsGshdrtirv.wdletgqcleetlsghdg...vvncvvvhpdgnllvsGslDrtvrlWdl...ktgkllrt 174
           ++s+++++f  ++   ++s ++d+ i      +t   l+ + + h +   +   + ++ ++++++ ++ Dr vr+++    k++k+ + 
   Q: 581  SSSITAIKFAGTRdVQMISCGADKSIYFrSAQQTSDGLHFVRTHHVAektTLYDMDIDITQKYVAVACQDRNVRVYNTvsgKQKKCYKG 669
           *******9999775789999999999875444444444423333332000233456777789999999*******99977778888888 PP
   S: 175  ltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
            +g +++s  ++ +d++g++l++   d+++ + d+ +gecv ++ gh++ v+ ++f+ +  +l+++s D  ++iW l
   Q: 670  SQG-DEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL 745
           888.9999999999999999999999*******************************9***************9943 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MMAALAAGGY ARSDTIEKLS SVMAGVPARR NQSSPPPAPP LCLRRRTRLA AAPEDTVQNR 60
VTLEKVLGIT AQNSSGLTCD PGTGHVAYLA GCVVVVLNPK ENKQQHIFNT TRDSISALLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATGGCTG CCTTAGCGGC CGGAGGTTAC GCGCGGAGTG ACACGATAGA AAAGCTGTCC 60
TCTGTCATGG CGGGAGTTCC GGCGCGGAGA AACCAGTCCT CCCCGCCTCC TGCCCCACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR030545--WDR62

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0071011--C:precatalytic spliceosome
GO:0000922--C:spindle pole
GO:0005682--C:U5 snRNP
GO:0007052--P:mitotic spindle organization
GO:0002052--P:positive regulation of neuroblast proliferation
GO:2001224--P:positive regulation of neuron migration
GO:0046605--P:regulation of centrosome cycle
GO:0045664--P:regulation of neuron differentiation
GO:0008380--P:RNA splicing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Pca-100323	Procavia capensis	67.64	0.00e+00	1281.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence