iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-051979

Ensembl Protein ID

ENSLOCP00000009304.1

UniProt Accession

W5MLP5; W5MLP5_LEPOC

Genbank Protein ID

ENSLOCP00000009304

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AHAT01032524

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000007661.1	ENSLOCT00000009315.1	ENSLOCP00000009304.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.70e-37	127.6	957	1008

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCr 52
            C+vC+e+  +e+ l++C++C++w+H+ C +l  e+e+++ ++  ++C+ C+
   Q: 957  TCPVCRENFMEEELLLQCQHCDRWMHAVCESLYTEDEVEQASDegFTCTACS 1008
           6********************************999999888889******6 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MAEQKSNCEE NDSETAADDS APPEQPVLSE GEPNPTPAEE TPKMAGETPA PPMEDGRSCA 60
LCNCEDRSLY GQRELRLFAP SADRPPLPHA ATASSSDPPA GCAGPGADDL DTIGFPELTA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGAAC AGAAATCCAA CTGCGAGGAA AATGATTCCG AAACAGCAGG TACTGGGACT 60
GTCTGAGCGA GGGGTGGCGC CGACCTGTTC TCCTNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	32.74	7.00e-15	75.90
IUUC-Aml-001806	Ailuropoda melanoleuca	83.57	0.00e+00	1026.00
IUUC-Aca-005364	Anolis carolinensis	83.74	0.00e+00	1004.00
IUUC-Ame-010612	Astyanax mexicanus	56.79	0.00e+00	2290.00
IUUC-Bta-013011	Bos taurus	82.81	0.00e+00	1039.00
IUUC-Cel-018354	Caenorhabditis elegans	34.15	1.00e-64	243.00
IUUC-Cja-019841	Callithrix jacchus	83.78	0.00e+00	1030.00
IUUC-Cfa-021131	Canis familiaris	83.78	0.00e+00	1030.00
IUUC-Cpo-021957	Cavia porcellus	82.64	0.00e+00	1033.00
IUUC-Csa-023722	Chlorocebus sabaeus	83.96	0.00e+00	1031.00
IUUC-Dno-029932	Dasypus novemcinctus	83.78	0.00e+00	1029.00
IUUC-Ete-032572	Echinops telfairi	84.78	0.00e+00	858.00
IUUC-Eeu-034848	Erinaceus europaeus	56.21	0.00e+00	741.00
IUUC-Fca-035424	Felis catus	84.14	0.00e+00	1034.00
IUUC-Fal-037179	Ficedula albicollis	83.60	0.00e+00	1008.00
IUUC-Gmo-038719	Gadus morhua	62.99	0.00e+00	1118.00
IUUC-Gga-040815	Gallus gallus	50.88	0.00e+00	758.00
IUUC-Gac-042436	Gasterosteus aculeatus	57.78	0.00e+00	1530.00
IUUC-Ggo-044711	Gorilla gorilla	83.78	0.00e+00	1030.00
IUUC-Hsa-046567	Homo sapiens	83.78	0.00e+00	1030.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	83.78	0.00e+00	1030.00
IUUC-Laf-054377	Loxodonta africana	82.81	0.00e+00	1039.00
IUUC-Mcc-055577	Macaca mulatta	77.90	0.00e+00	934.00
IUUC-Meu-055992	Macropus eugenii	84.90	0.00e+00	983.00
IUUC-Mmr-061772	Microcebus murinus	83.78	0.00e+00	1029.00
IUUC-Mdo-062876	Monodelphis domestica	67.32	7.00e-134	472.00
IUUC-Mmu-063903	Mus musculus	83.54	0.00e+00	1020.00
IUUC-Mpu-066700	Mustela putorius furo	83.96	0.00e+00	1031.00
IUUC-Mlu-068180	Myotis lucifugus	82.64	0.00e+00	1036.00
IUUC-Opr-070304	Ochotona princeps	72.91	0.00e+00	830.00
IUUC-Ont-071881	Oreochromis niloticus	67.02	0.00e+00	1142.00
IUUC-Ocu-074053	Oryctolagus cuniculus	83.78	0.00e+00	1029.00
IUUC-Osa-085421	Oryza sativa	31.02	2.00e-25	110.00
IUUC-Ola-086384	Oryzias latipes	69.24	0.00e+00	1570.00
IUUC-Oga-088450	Otolemur garnettii	82.81	0.00e+00	1038.00
IUUC-Oar-089975	Ovis aries	82.47	0.00e+00	1029.00
IUUC-Ptr-091073	Pan troglodytes	81.82	0.00e+00	898.00
IUUC-Pan-092871	Papio anubis	83.96	0.00e+00	1032.00
IUUC-Pfo-097525	Poecilia formosa	65.33	0.00e+00	1093.00
IUUC-Pab-097679	Pongo abelii	83.78	0.00e+00	1030.00
IUUC-Pca-100499	Procavia capensis	83.78	0.00e+00	1031.00
IUUC-Pva-102898	Pteropus vampyrus	83.42	0.00e+00	1019.00
IUUC-Rno-105660	Rattus norvegicus	81.80	0.00e+00	952.00
IUUC-Sha-107431	Sarcophilus harrisii	84.53	0.00e+00	994.00
IUUC-Sbi-113816	Sorghum bicolor	38.82	1.00e-12	68.90
IUUC-Ssc-115678	Sus scrofa	83.51	0.00e+00	1023.00
IUUC-Tru-117922	Takifugu rubripes	58.14	0.00e+00	1453.00
IUUC-Tur-126568	Triticum urartu	35.06	2.00e-11	64.70
IUUC-Tbe-127625	Tupaia belangeri	70.68	1.00e-109	393.00
IUUC-Ttr-129162	Tursiops truncatus	82.81	0.00e+00	1041.00
IUUC-Xtr-132455	Xenopus tropicalis	82.10	0.00e+00	993.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence