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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018320
Ensembl Protein ID Y37E11AR.2
UniProt Accession Q965X6; O46223; SIAH1_CAEEL
Genbank Protein ID AAB94380.1; CCD74038.1
Protein Name E3 ubiquitin-protein ligase siah-1; RING-type E3 ubiquitin transferase SIAH1; Seven in absentia homolog 1
Genbank Nucleotide ID U89792; FO081773
Gene Name siah-1; Y37E11AR.2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00021369 Y37E11AR.2 Y37E11AR.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 33.72 4.00e-35 145.00 IUUC-Ath-007192
E3 activity/RING/RING 69.73 2.00e-109 393.00 IUUC-Dme-031700
E3 activity/RING/RING 61.98 4.00e-113 405.00 IUUC-Hsa-046357
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
Protein Sequence
(Fasta)
MSNRNGGGGG GDYQDVIESL RRTQLIFEED DNNSSDSAPQ ANHLSRHQTS NSLVEDMVNH 60
SNGNPPPVPP GITQQQCQIG LTPRMSASPP SAVSTISGTA VLGKTMARVQ SNPPGSIPHN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018320|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGAGACGAC GGGAAGACGG CGGCATCCGC AGACACCGAA CCACCCACCA CCTCCAACAT 60
CGTCGTCCTC GTCATCTCGA CTGCCTTCGC TGATGAGTAA TCGGAACGGT GGTGGAGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018320|E3,RING|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH
PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH
Pfam

PF03145--Sina
Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG cel:CELE_Y37E11AR.2
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000061 Aegilops tauschii 33.89 2.00e-35 141.00
IUUC-Aml-001186 Ailuropoda melanoleuca 66.43 5.00e-115 405.00
IUUC-Atr-003118 Amborella trichopoda 33.46 3.00e-38 150.00
IUUC-Apl-003813 Anas platyrhynchos 67.15 4.00e-115 405.00
IUUC-Aca-005014 Anolis carolinensis 67.15 4.00e-115 405.00
IUUC-Aly-006522 Arabidopsis lyrata 33.33 2.00e-36 145.00
IUUC-Ath-007192 Arabidopsis thaliana 33.72 8.00e-37 146.00
IUUC-Ame-011196 Astyanax mexicanus 63.17 1.00e-117 414.00
IUUC-Bta-012887 Bos taurus 66.79 2.00e-115 407.00
IUUC-Bdi-014200 Brachypodium distachyon 34.31 6.00e-36 143.00
IUUC-Bol-015884 Brassica oleracea 33.11 8.00e-38 149.00
IUUC-Bra-016775 Brassica rapa 33.45 6.00e-38 149.00
IUUC-Cja-019796 Callithrix jacchus 66.43 1.00e-114 404.00
IUUC-Cfa-020642 Canis familiaris 62.78 4.00e-116 409.00
IUUC-Cpo-022348 Cavia porcellus 71.21 8.00e-115 404.00
IUUC-Csa-023974 Chlorocebus sabaeus 61.98 3.00e-115 406.00
IUUC-Cho-024933 Choloepus hoffmanni 69.32 2.00e-109 386.00
IUUC-Cin-025674 Ciona intestinalis 66.28 5.00e-108 382.00
IUUC-Csv-026233 Ciona savignyi 68.80 4.00e-107 379.00
IUUC-Dre-028041 Danio rerio 63.17 9.00e-118 415.00
IUUC-Dno-029764 Dasypus novemcinctus 65.62 1.00e-115 407.00
IUUC-Dor-030489 Dipodomys ordii 71.20 5.00e-80 288.00
IUUC-Dme-031700 Drosophila melanogaster 70.63 9.00e-103 365.00
IUUC-Ete-032946 Echinops telfairi 69.32 8.00e-109 385.00
IUUC-Eca-033536 Equus caballus 67.15 4.00e-115 405.00
IUUC-Eeu-035314 Erinaceus europaeus 63.18 2.00e-106 377.00
IUUC-Fca-035362 Felis catus 67.15 4.00e-115 405.00
IUUC-Fal-037487 Ficedula albicollis 64.19 3.00e-115 406.00
IUUC-Gmo-039091 Gadus morhua 68.77 4.00e-109 386.00
IUUC-Gga-040269 Gallus gallus 67.15 4.00e-115 405.00
IUUC-Gac-042282 Gasterosteus aculeatus 72.37 1.00e-116 410.00
IUUC-Gma-042926 Glycine max 33.46 4.00e-36 143.00
IUUC-Ggo-045444 Gorilla gorilla 61.98 3.00e-115 406.00
IUUC-Hsa-046357 Homo sapiens 61.98 3.00e-115 406.00
IUUC-Hvu-047574 Hordeum vulgare 33.47 3.00e-35 140.00
IUUC-Itr-048046 Ictidomys tridecemlineatus 71.21 8.00e-115 404.00
IUUC-Lch-049504 Latimeria chalumnae 68.23 1.00e-116 410.00
IUUC-Lpe-050879 Leersia perrieri 34.16 1.00e-34 138.00
IUUC-Loc-052191 Lepisosteus oculatus 67.87 7.00e-116 408.00
IUUC-Laf-053668 Loxodonta africana 67.15 4.00e-115 405.00
IUUC-Mcc-054640 Macaca mulatta 61.98 3.00e-115 406.00
IUUC-Meu-055922 Macropus eugenii 68.92 5.00e-107 379.00
IUUC-Mtr-058747 Medicago truncatula 32.55 1.00e-37 149.00
IUUC-Mga-059503 Meleagris gallopavo 67.15 5.00e-115 405.00
IUUC-Mmr-060794 Microcebus murinus 71.21 8.00e-115 404.00
IUUC-Mdo-061971 Monodelphis domestica 69.72 2.00e-109 387.00
IUUC-Mmu-063876 Mus musculus 67.87 2.00e-115 406.00
IUUC-Mac-065014 Musa acuminata 35.16 8.00e-38 149.00
IUUC-Mpu-066488 Mustela putorius furo 66.43 5.00e-115 405.00
IUUC-Mlu-067207 Myotis lucifugus 67.15 2.00e-115 406.00
IUUC-Nle-069706 Nomascus leucogenys 62.30 1.00e-115 407.00
IUUC-Opr-070341 Ochotona princeps 46.88 7.00e-42 162.00
IUUC-Ont-071849 Oreochromis niloticus 72.37 1.00e-116 410.00
IUUC-Oan-073701 Ornithorhynchus anatinus 47.85 8.00e-42 162.00
IUUC-Ocu-074876 Oryctolagus cuniculus 71.21 1.00e-114 404.00
IUUC-Oba-075789 Oryza barthii 33.85 2.00e-37 148.00
IUUC-Obr-076037 Oryza brachyantha 33.85 3.00e-37 147.00
IUUC-Ogl-077148 Oryza glaberrima 33.85 2.00e-37 148.00
IUUC-Ogu-078042 Oryza glumaepatula 33.85 2.00e-37 147.00
IUUC-Oin-079325 Oryza indica 33.85 2.00e-37 147.00
IUUC-Olo-080244 Oryza longistaminata 34.50 2.00e-37 149.00
IUUC-Ome-081318 Oryza meridionalis 34.57 5.00e-35 140.00
IUUC-Oni-082163 Oryza nivara 33.85 2.00e-37 148.00
IUUC-Opu-084065 Oryza punctata 34.98 3.00e-35 140.00
IUUC-Oru-084833 Oryza rufipogon 33.85 2.00e-37 147.00
IUUC-Osa-085316 Oryza sativa 33.85 2.00e-37 147.00
IUUC-Ola-086814 Oryzias latipes 72.37 1.00e-116 410.00
IUUC-Oga-088399 Otolemur garnettii 71.21 8.00e-115 404.00
IUUC-Oar-089323 Ovis aries 66.79 2.00e-115 407.00
IUUC-Ptr-090692 Pan troglodytes 71.21 9.00e-115 404.00
IUUC-Pan-092012 Papio anubis 61.98 3.00e-115 406.00
IUUC-Psi-093687 Pelodiscus sinensis 67.15 3.00e-115 406.00
IUUC-Pma-094387 Petromyzon marinus 69.77 5.00e-111 392.00
IUUC-Ppa-095212 Physcomitrella patens 32.96 1.00e-35 142.00
IUUC-Pfo-097134 Poecilia formosa 72.37 1.00e-116 410.00
IUUC-Pab-097555 Pongo abelii 61.98 3.00e-115 406.00
IUUC-Pop-099970 Populus trichocarpa 31.56 4.00e-38 150.00
IUUC-Pca-100328 Procavia capensis 68.13 2.00e-105 374.00
IUUC-Ppe-101760 Prunus persica 34.80 1.00e-37 148.00
IUUC-Pva-102368 Pteropus vampyrus 69.37 2.00e-43 168.00
IUUC-Rno-104866 Rattus norvegicus 71.60 3.00e-115 406.00
IUUC-Sha-106547 Sarcophilus harrisii 67.15 3.00e-115 406.00
IUUC-Smo-109412 Selaginella moellendorffii 30.71 2.00e-35 141.00
IUUC-Sit-110245 Setaria italica 33.72 6.00e-37 146.00
IUUC-Sly-111259 Solanum lycopersicum 33.33 3.00e-37 147.00
IUUC-Stu-112571 Solanum tuberosum 33.33 2.00e-37 147.00
IUUC-Sbi-114035 Sorghum bicolor 33.33 1.00e-36 145.00
IUUC-Ssc-116441 Sus scrofa 69.32 5.00e-109 385.00
IUUC-Tgu-116579 Taeniopygia guttata 67.15 4.00e-115 405.00
IUUC-Tru-118250 Takifugu rubripes 71.60 3.00e-114 402.00
IUUC-Tsy-119548 Tarsius syrichta 68.18 4.00e-49 186.00
IUUC-Tni-120488 Tetraodon nigroviridis 71.60 1.00e-112 397.00
IUUC-Tca-121228 Theobroma cacao 33.46 5.00e-37 146.00
IUUC-Tae-123647 Triticum aestivum 33.89 2.00e-35 141.00
IUUC-Tur-126049 Triticum urartu 33.85 1.00e-36 145.00
IUUC-Ttr-129166 Tursiops truncatus 69.14 3.00e-104 370.00
IUUC-Vpa-130799 Vicugna pacos 72.51 2.00e-74 270.00
IUUC-Vvi-131451 Vitis vinifera 33.99 3.00e-36 144.00
IUUC-Xtr-132553 Xenopus tropicalis 67.15 9.00e-115 404.00
IUUC-Xma-133670 Xiphophorus maculatus 72.37 1.00e-116 410.00
Created Date 25-Jun-2017

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