iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052736

Ensembl Protein ID

ENSLOCP00000011273.1

UniProt Accession

W5MSB4; W5MSB4_LEPOC

Genbank Protein ID

ENSLOCP00000011273

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01015458

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000009225.1	ENSLOCT00000011279.1	ENSLOCP00000011263.1
ENSLOCG00000009225.1	ENSLOCT00000011289.1	ENSLOCP00000011273.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-81	274.4	711	1030

Active Site

Position(s)	Description	Evidence
1000	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++dl+k+l vefvg+  + +   +++f+  ++++l  pd g+f y+e+++ +++p++ +      + ++F ++G+l+g+a+++++++
   Q: 711  DEDLRKELSVEFVGDLEQTA-VNKKDFFLHIFDQLIAPDSGMFWYNESNSLMWFPSNPTLA----QKRYF-LFGILCGLAMYNNNIV 791
           689***********765555.579**********************************984....66888.55************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            lp++ +f+k+l+g+k +ledlee+d+ l +slk i+e++e+d e   ldltf+vs     + k+++L p+ ++  V+n+Nk+++v+
   Q: 792  HLPFPLAFFKKLVGVKPTLEDLEELDSVLGRSLKCILESDEEDFEV--LDLTFTVSW----DKKDVHLDPQENEKAVNNANKKQFVS 872
           **************************************98766666..577777555....446677******************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           + v+y +++++++ +e+f++Gf++v++ ++l+ F++eel  +i G+e++d+e+lk++t y+g+y++++  i+ Fwev+ e+s ee+k
   Q: 873  AFVDYVFNKSVAKLFEEFKRGFYKVCNVDILEFFQPEELMGVIVGKEDYDWEKLKQNTLYEGEYHANHANIRLFWEVFDELSTEEKK 959
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
            fL FvTg++r+P+ G++ +k r+ +++   +++++P+s TC ++L LP+Ys+ke l+ kL+ Ai++++gF 
   Q: 960  SFLLFVTGCDRVPILGMNCIKMRISILPH-FTEEHFPESLTCHSLLLLPKYSTKERLRTKLIGAINHKRGFC 1030
           *********************87766666.9**************************************995 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

VNMYCWGEGT SGQLGLDLQE NDSLVLQPAE VHPLLRHVSL VACGEQHTLF LNEEGKVLSS 60
GRNSKGQLGR QSIPDQKTPA RVQGLTGVVS VACGQEHSLA LCQSGQVYSW GRGSEGQLGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGGACACCA GGATCGGAAG ATAAAAAAAA GTCGCAGTCA CAGACTTAAA GCAGTTTGAA 60
CAGCCAGCCT GTTCACATCC TTGACTACAC TGCCGGTGAA CATGTACTGC TGGGGAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011023	Astyanax mexicanus	46.84	0.00e+00	916.00
IUUC-Cpo-022346	Cavia porcellus	41.27	0.00e+00	730.00
IUUC-Dor-030862	Dipodomys ordii	35.05	3.00e-143	503.00
IUUC-Gmo-038792	Gadus morhua	43.69	0.00e+00	721.00
IUUC-Gac-041342	Gasterosteus aculeatus	46.46	0.00e+00	847.00
IUUC-Mdo-061839	Monodelphis domestica	40.50	0.00e+00	675.00
IUUC-Ont-071328	Oreochromis niloticus	49.18	0.00e+00	967.00
IUUC-Pfo-096202	Poecilia formosa	48.99	0.00e+00	889.00
IUUC-Pca-100320	Procavia capensis	38.53	2.00e-180	626.00
IUUC-Tru-117816	Takifugu rubripes	45.39	0.00e+00	829.00
IUUC-Tni-120770	Tetraodon nigroviridis	40.41	4.00e-180	625.00
IUUC-Xtr-132481	Xenopus tropicalis	41.46	0.00e+00	721.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence