iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069986

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01030588

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000009725.2	ENSNLET00000012445.2	ENSNLEP00000011863.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.90e-91	304.9	703	1024

Active Site

Position(s)	Description	Evidence
994	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++dl+k+l+v+f+gE g dlgGv++ef+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G+l+g++l++ ++ 
   Q: 703  NEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFEEMIQPEYGMFMYPEGASCMWFPVKPKF----EKKRYF-FFGVLCGLSLFNCNVA 784
           689********************************************************9....567888.99************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           +lp++ +++k+ll++  sledl+e+ p+l k+l+ +++ + ++ e       f ++ ++  ++++++L+p+G++i V+++Nk++Yv+
   Q: 785  NLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFE-----EVFYIHFNVHWDRNDTNLIPNGSSIIVNQTNKRDYVS 866
           *************************************87544444.....455555667779999********************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++++y++++++k  +e+fr+Gf++++++++++lF++eel+ +i G++++d+++++k+++y+ gy++++p+i +Fw+++++++ ee+k
   Q: 867  KYIDYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKK 953
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL F+Tg++rl ++ ++++k   f+++++ ++++  ++ TCfn+L LP+Ys++e+++e L+ Ai++++gF+
   Q: 954  QFLVFLTGTDRLQMKDLNNMK-ITFCCPESWNERDPMRALTCFNVLFLPKYSTMETVEEALQEAINNSRGFG 1024
           *********************.7799999999**************************************96 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MERRSRRKSR RNGRSTAGAA AASQPAKSPG AQLWLFPSAA GFHRALLRRA EVTRQICCSP 60
GRLAVLERGG AVVQVHQLLP GSGGARTPKC IKLGKNMKIH SVDQGAEHML ILSSDGKPFE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCGGA GGTCGCGGAG GAAGTCGCGG CGCAACGGGC GCTCGACCGC GGGCGCGGCC 60
GCCGCGTCCC AGCCCGCGAA GTCTCCGGGC GCGCAGCTCT GGCTCTTCCC CAGCGCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

KEGG

nle:100584608

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	76.33	0.00e+00	1582.00
IUUC-Bta-012422	Bos taurus	67.37	0.00e+00	1244.00
IUUC-Cja-018751	Callithrix jacchus	91.42	0.00e+00	1891.00
IUUC-Cfa-020247	Canis familiaris	76.08	0.00e+00	1497.00
IUUC-Csa-023204	Chlorocebus sabaeus	95.69	0.00e+00	1731.00
IUUC-Cho-025101	Choloepus hoffmanni	62.58	3.00e-177	615.00
IUUC-Dno-029795	Dasypus novemcinctus	70.38	0.00e+00	1138.00
IUUC-Dor-030862	Dipodomys ordii	65.96	0.00e+00	1279.00
IUUC-Ete-032585	Echinops telfairi	60.14	0.00e+00	837.00
IUUC-Eca-034358	Equus caballus	75.62	0.00e+00	1470.00
IUUC-Eeu-035282	Erinaceus europaeus	65.75	0.00e+00	734.00
IUUC-Fca-036505	Felis catus	77.09	0.00e+00	1560.00
IUUC-Ggo-045445	Gorilla gorilla	93.86	0.00e+00	1826.00
IUUC-Hsa-046342	Homo sapiens	96.83	0.00e+00	1935.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	70.67	0.00e+00	1429.00
IUUC-Laf-053921	Loxodonta africana	72.59	0.00e+00	1475.00
IUUC-Mcc-054850	Macaca mulatta	95.80	0.00e+00	1738.00
IUUC-Mmr-060783	Microcebus murinus	66.70	0.00e+00	1203.00
IUUC-Mpu-066123	Mustela putorius furo	75.80	0.00e+00	1560.00
IUUC-Mlu-067914	Myotis lucifugus	76.18	0.00e+00	1425.00
IUUC-Opr-070513	Ochotona princeps	68.65	0.00e+00	1037.00
IUUC-Ocu-074305	Oryctolagus cuniculus	72.52	0.00e+00	1383.00
IUUC-Oga-088858	Otolemur garnettii	75.62	0.00e+00	832.00
IUUC-Oar-089456	Ovis aries	76.00	0.00e+00	1501.00
IUUC-Ptr-091216	Pan troglodytes	97.24	0.00e+00	1700.00
IUUC-Pan-091706	Papio anubis	94.56	0.00e+00	1857.00
IUUC-Pab-097883	Pongo abelii	97.37	0.00e+00	795.00
IUUC-Pca-100320	Procavia capensis	66.13	0.00e+00	1348.00
IUUC-Pva-102646	Pteropus vampyrus	77.48	0.00e+00	1572.00
IUUC-Sar-113605	Sorex araneus	75.68	1.00e-151	530.00
IUUC-Tsy-119240	Tarsius syrichta	66.92	0.00e+00	1245.00
IUUC-Tbe-127787	Tupaia belangeri	71.09	0.00e+00	1352.00
IUUC-Ttr-128191	Tursiops truncatus	74.10	0.00e+00	1471.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence