iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117770

UUCD1 version

UUC-TaR-01127

Ensembl Protein ID

ENSTRUP00000047086.1

UniProt Accession

H2VCZ2; H2VCZ2_TAKRU

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

usp20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000018404.1	ENSTRUT00000047245.1	ENSTRUP00000047086.1
ENSTRUG00000018404.1	ENSTRUT00000047246.1	ENSTRUP00000047087.1
ENSTRUG00000018404.1	ENSTRUT00000047247.1	ENSTRUP00000047088.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-108	364.4	149	694

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++l+     ++   ++++k +l+ks+qkl++elw k++ ++v p++l + +k ++++f+gy+
   Q: 149  TGMKNIGNSCYMNAALQALSNCPPLTQFFLD-----CSGLVRTDKKPALCKSYQKLISELWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 232
           7******************************.....9999999******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde................................................ 129
           qqD+qEfl++l+dql+eelk+  ++  ++ e++d ++  d                                                 
   Q: 233  QQDTQEFLRCLMDQLHEELKEPLTECSMSGEGSDGEDIRDGehspsedeflscdsgsssdrgegggageselllqdvcdgiapptggsv 321
           *******************885555555555554443333366777777899999999999**************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 322  gnstggvisekerlkekrvsgsplrggsqemdedadvdtaaeeahqitdtgpeqtesntpgccflepdneasmaqpqsthcspvrtlqe 410
           ***************************************************************************************** PP
   S: 130  ................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke. 185
                                           +++kk+ + +s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+ 
   Q: 411  lqpklssspprssplrsagpsysfkksqtmlsSKKKKQFHFRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLh 499
           ******************************988888888899*****************************************99888* PP
   S: 186  ................................................slqdcLesftkeeelegenkyycekckkkqeaekklklkkl 226
                                                           +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ kl
   Q: 500  ssihqnlpvktgtcpdsynsqgwisyimdsirrfvvsciptwfwgpmvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLKL 588
           ***************************************************************************************** PP
   S: 227  PevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDsk 313
           Pe+L++hLkRf  ++e + + ki ++v+fple L+++pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++
   Q: 589  PEILCIHLKRF--RHEVMYSFKIGSHVSFPLEgLNMQPFLAKDSPSQ--VTTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQY 673
           ***********..9999*************************88887..9**************************78999******** PP
   S: 314  VtevkeeevleetgstaYvlfYkr 337
           Vtev+e+ v++   ++aYvlfY++
   Q: 674  VTEVHETVVQN---AEAYVLFYRK 694
           ***********...********98 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MADQDICPHV DSIGEITKED LLLKAKGTCQ SCTAGGPNLW ACLQSDCSYV GCGESYSDHS 60
TLHAQAKKHN LTVNLTTFRI WCYVCEREVF LDHRATLVPV PAVSHHCKAT EHKAAAQPAG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGATC AAGACATTTG TCCGCACGTC GACTCAATAG GAGAGATAAC CAAGGAAGAC 60
CTCCTACTGA AAGCTAAGGT AGGTTTATTT CCTTCCCCAC AGTCAATCCC CTGCACAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	71.57	0.00e+00	1293.00
IUUC-Apl-003351	Anas platyrhynchos	74.81	0.00e+00	1353.00
IUUC-Aca-005077	Anolis carolinensis	69.10	0.00e+00	1007.00
IUUC-Ame-011777	Astyanax mexicanus	79.57	0.00e+00	1435.00
IUUC-Bta-013063	Bos taurus	73.24	0.00e+00	1335.00
IUUC-Cja-019868	Callithrix jacchus	72.86	0.00e+00	1335.00
IUUC-Cfa-020761	Canis familiaris	72.13	0.00e+00	1312.00
IUUC-Cpo-022267	Cavia porcellus	71.50	0.00e+00	1306.00
IUUC-Csa-024251	Chlorocebus sabaeus	73.31	0.00e+00	1337.00
IUUC-Cho-024483	Choloepus hoffmanni	89.62	1.00e-117	417.00
IUUC-Csv-025889	Ciona savignyi	42.51	6.00e-36	143.00
IUUC-Dre-028061	Danio rerio	69.74	0.00e+00	1281.00
IUUC-Dno-029423	Dasypus novemcinctus	73.28	0.00e+00	1339.00
IUUC-Dor-030877	Dipodomys ordii	74.42	0.00e+00	890.00
IUUC-Dme-031837	Drosophila melanogaster	49.34	2.00e-135	476.00
IUUC-Ete-032802	Echinops telfairi	59.08	4.00e-103	369.00
IUUC-Eca-034283	Equus caballus	72.27	0.00e+00	1307.00
IUUC-Eeu-034620	Erinaceus europaeus	67.19	0.00e+00	869.00
IUUC-Fca-036357	Felis catus	73.18	0.00e+00	1322.00
IUUC-Fal-037411	Ficedula albicollis	74.46	0.00e+00	1348.00
IUUC-Gmo-038563	Gadus morhua	84.33	0.00e+00	902.00
IUUC-Gga-041101	Gallus gallus	74.00	0.00e+00	1338.00
IUUC-Gac-041315	Gasterosteus aculeatus	87.20	0.00e+00	1535.00
IUUC-Ggo-045600	Gorilla gorilla	72.79	0.00e+00	1311.00
IUUC-Hsa-045825	Homo sapiens	72.75	0.00e+00	1325.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	63.27	0.00e+00	1102.00
IUUC-Lch-050002	Latimeria chalumnae	71.94	0.00e+00	1272.00
IUUC-Loc-052574	Lepisosteus oculatus	81.10	0.00e+00	1456.00
IUUC-Laf-054428	Loxodonta africana	73.05	0.00e+00	1346.00
IUUC-Mcc-055736	Macaca mulatta	73.20	0.00e+00	1337.00
IUUC-Mga-059781	Meleagris gallopavo	74.62	0.00e+00	1339.00
IUUC-Mmr-061328	Microcebus murinus	83.44	0.00e+00	822.00
IUUC-Mdo-063048	Monodelphis domestica	74.15	0.00e+00	1315.00
IUUC-Mmu-064079	Mus musculus	72.52	0.00e+00	1310.00
IUUC-Mpu-066616	Mustela putorius furo	71.25	0.00e+00	1323.00
IUUC-Mlu-067294	Myotis lucifugus	72.21	0.00e+00	1298.00
IUUC-Nle-070015	Nomascus leucogenys	72.96	0.00e+00	1321.00
IUUC-Opr-070328	Ochotona princeps	72.29	0.00e+00	1316.00
IUUC-Ont-071464	Oreochromis niloticus	88.39	0.00e+00	1510.00
IUUC-Oan-073259	Ornithorhynchus anatinus	73.69	0.00e+00	736.00
IUUC-Ocu-074630	Oryctolagus cuniculus	70.16	0.00e+00	1271.00
IUUC-Ola-087240	Oryzias latipes	87.14	0.00e+00	1496.00
IUUC-Oga-088761	Otolemur garnettii	72.60	0.00e+00	1341.00
IUUC-Oar-089490	Ovis aries	70.63	0.00e+00	1229.00
IUUC-Ptr-091662	Pan troglodytes	72.75	0.00e+00	1324.00
IUUC-Pan-092199	Papio anubis	73.26	0.00e+00	1327.00
IUUC-Psi-093726	Pelodiscus sinensis	75.00	0.00e+00	1349.00
IUUC-Pma-094389	Petromyzon marinus	63.01	4.00e-99	353.00
IUUC-Pfo-096522	Poecilia formosa	88.13	0.00e+00	1156.00
IUUC-Pab-098632	Pongo abelii	72.75	0.00e+00	1321.00
IUUC-Pca-100614	Procavia capensis	68.30	0.00e+00	1058.00
IUUC-Pva-102922	Pteropus vampyrus	65.22	0.00e+00	704.00
IUUC-Rno-105215	Rattus norvegicus	72.52	0.00e+00	1302.00
IUUC-Sha-106601	Sarcophilus harrisii	72.92	0.00e+00	1304.00
IUUC-Ssc-115533	Sus scrofa	72.33	0.00e+00	1317.00
IUUC-Tgu-117364	Taeniopygia guttata	74.13	0.00e+00	1344.00
IUUC-Tni-120001	Tetraodon nigroviridis	93.61	0.00e+00	1603.00
IUUC-Ttr-128732	Tursiops truncatus	74.17	0.00e+00	1342.00
IUUC-Xtr-132157	Xenopus tropicalis	68.25	0.00e+00	1256.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence