iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041983

UUCD1 version

UUC-GaA-00960

Ensembl Protein ID

ENSGACP00000024100.1

UniProt Accession

G3Q2K1; G3Q2K1_GASAC

Protein Name

Uncharacterized protein

Gene Name

SMURF2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000018228.1	ENSGACT00000024147.1	ENSGACP00000024100.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-127	425.6	424	756

Active Site

Position(s)	Description	Evidence
725	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 424  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 511
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+l++sl +i++n   di+   ld tf+v+++ +ge+ ++eLkp+G+++pV ++ k+eYv+l+v+
   Q: 512  GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILDN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSVPVSEDTKKEYVRLYVN 596
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+  gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id++d+k++t+ k+ +t+ds+ ++wFw+++e+f++e r+++LqFv
   Q: 597  WRFLHGIEAQFLALQKGFNEVIPQHLLKSFDEKELELIVCGLGKIDISDWKSNTRLKH-CTPDSNIVKWFWKAVESFDEERRARLLQFV 684
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da+ ++lP+++TCfn++++P+Y+s+++l++kLl+Aieet gF +
   Q: 685  TGSSRVPLQGFKALQgaagPRLFTIHQiDANANNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEETCGFAV 756
           ***************************99999**************************************76 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

ENREGHKSPG PARFELPVLC AKNLAKKDFF RLPDPFAKVV VDGSGQCHST DTVRNTLDPK 60
WNQHYDLYIG KADSITISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDMNKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAACAGGG AGGGGCATAA AAGCCCTGGT CCAGCACGGT TCGAGGTGTG GTGTTTCTCT 60
CCGGCATGAT TCACGACTAC TGCTGGTTAT TTTGGTTTGG GCTTCATTTG TTTTGGCTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005358	Anolis carolinensis	91.10	0.00e+00	1414.00
IUUC-Ame-011320	Astyanax mexicanus	88.28	0.00e+00	1399.00
IUUC-Cho-024804	Choloepus hoffmanni	93.85	7.00e-178	617.00
IUUC-Mpo-057442	Magnaporthe poae	38.14	1.00e-145	510.00
IUUC-Ont-072243	Oreochromis niloticus	93.53	0.00e+00	1502.00
IUUC-Oan-072699	Ornithorhynchus anatinus	88.43	0.00e+00	1401.00
IUUC-Ola-087161	Oryzias latipes	88.56	0.00e+00	1302.00
IUUC-Pfo-096142	Poecilia formosa	93.55	0.00e+00	1465.00
IUUC-Pca-100516	Procavia capensis	85.17	2.00e-175	609.00
IUUC-Tru-118497	Takifugu rubripes	94.98	0.00e+00	1469.00
IUUC-Tni-120781	Tetraodon nigroviridis	96.28	0.00e+00	1277.00
IUUC-Tme-126897	Tuber melanosporum	38.77	3.00e-152	532.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence