iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090307

Ensembl Protein ID

ENSOARP00000001192.1

UniProt Accession

W5NSQ2; W5NSQ2_SHEEP

Genbank Protein ID

ENSOARP00000001192

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01097194

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000001138.1	ENSOART00000001229.1	ENSOARP00000001192.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.40e-83	280.0	670	989

Active Site

Position(s)	Description	Evidence
960	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
            dl+k l vef +E     +Gv++ef++++++ + + ++g+f y e+d+++++p + ++     +  +F ++G+l+g++l++ +++ lp
   Q: 670  TDLRKTLVVEFIKEIRSVGDGVKSEFFHCIFESMTKEEYGMFIYPEEDSYMWFPVNPKFE----KKMYF-LFGMLCGLSLYNFNVVYLP 753
           7999***********99999**********************************999983....44555.77***************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           ++ +++k+ll+++ sledl+e+ p + k l+e+++ + +di+e+ l ++fs+      +++++ L+p+G ++ V ++Nk++Yv++ v+y
   Q: 754  FPLALFKKLLDQEPSLEDLKELSPSFGKCLQEVLNDDANDIKEE-LGIRFSI----PWDQNDVGLIPDGISVFVDQSNKKDYVSKCVDY 837
           ************************************99999997.*****84....45678888************************* PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
            +++++k  +e+f++Gf++++++e+l+ F++eel   i G++++d+++++k+  y++gy+e++p+i +Fw+++++++ +e+++fL F+T
   Q: 838  VFNTSVKAVYEEFQRGFYKLFDKEILKHFKPEELMRAIIGNTDYDWKQFEKNSIYDQGYHESHPTILMFWKAFHNLTLDEKRKFLFFLT 926
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           g++rl ++G+++     f +++  s++++P+s TC n L+LP+Ys+++++k+ L++Ai+++kgF
   Q: 927  GNDRLHVKGIRKTG-IWFRCPETFSERDFPRSLTCHNILELPKYSTMKKMKKALQIAINSNKGF 989
           **************.77888888****************************************9 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

AMSGEHHSLL LLSDGTVQSC GDNSRGQLGR KGTPRGEQPE RIPALETLHV ALVSCGKEHS 60
LAVCHKGRVF AWGAASEGQL GIGELKETTF IPKKIKTLAD IKIIQVACGH YHSLALSEDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGATGAGTG GGGAGCATCA CTCGCTATTG CTGCTGAGCG ACGGCACGGT CCAGTCGTGC 60
GGGGACAACA GCCGAGGCCA GCTGGGCCGG AAAGGCACGC CGCGCGGGGA GCAGCCAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	74.25	0.00e+00	1417.00
IUUC-Aca-004663	Anolis carolinensis	48.47	0.00e+00	867.00
IUUC-Bta-013080	Bos taurus	89.96	0.00e+00	1771.00
IUUC-Cja-018891	Callithrix jacchus	70.51	0.00e+00	1384.00
IUUC-Cfa-020763	Canis familiaris	73.35	0.00e+00	1370.00
IUUC-Cpo-022346	Cavia porcellus	68.41	0.00e+00	1399.00
IUUC-Csa-023049	Chlorocebus sabaeus	73.85	0.00e+00	1498.00
IUUC-Dno-029093	Dasypus novemcinctus	71.79	0.00e+00	1415.00
IUUC-Eca-034098	Equus caballus	76.46	0.00e+00	1449.00
IUUC-Eeu-035028	Erinaceus europaeus	61.38	5.00e-162	565.00
IUUC-Fca-036283	Felis catus	76.48	0.00e+00	1457.00
IUUC-Ggo-045553	Gorilla gorilla	71.83	0.00e+00	1388.00
IUUC-Hsa-046396	Homo sapiens	74.25	0.00e+00	1461.00
IUUC-Loc-052700	Lepisosteus oculatus	40.56	0.00e+00	767.00
IUUC-Laf-054433	Loxodonta africana	70.71	0.00e+00	1444.00
IUUC-Mcc-055014	Macaca mulatta	70.07	0.00e+00	1422.00
IUUC-Mdo-061839	Monodelphis domestica	57.06	0.00e+00	1015.00
IUUC-Mmu-064378	Mus musculus	63.82	0.00e+00	1212.00
IUUC-Mpu-066293	Mustela putorius furo	71.11	0.00e+00	1324.00
IUUC-Mlu-067407	Myotis lucifugus	73.43	0.00e+00	1444.00
IUUC-Nle-069978	Nomascus leucogenys	74.35	0.00e+00	1498.00
IUUC-Opr-070190	Ochotona princeps	59.06	0.00e+00	683.00
IUUC-Oga-088780	Otolemur garnettii	65.92	0.00e+00	1332.00
IUUC-Ptr-091567	Pan troglodytes	74.05	0.00e+00	1450.00
IUUC-Pan-091802	Papio anubis	69.25	0.00e+00	1385.00
IUUC-Pab-098024	Pongo abelii	58.86	0.00e+00	1083.00
IUUC-Pca-100315	Procavia capensis	58.50	0.00e+00	823.00
IUUC-Pva-102382	Pteropus vampyrus	71.44	0.00e+00	1361.00
IUUC-Rno-105768	Rattus norvegicus	61.15	0.00e+00	1191.00
IUUC-Sha-106525	Sarcophilus harrisii	53.63	0.00e+00	1037.00
IUUC-Sar-113014	Sorex araneus	62.45	3.00e-165	575.00
IUUC-Vpa-130214	Vicugna pacos	73.49	0.00e+00	1352.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence