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Tag Content
UUCD2 ID IUUC-Sha-107122
UUCD1 version UUC-SaH-00296
Ensembl Protein ID ENSSHAP00000008024.1
UniProt Accession G3VXW9; G3VXW9_SARHA
Genbank Protein ID ENSSHAP00000008024
Protein Name Ribosome biogenesis protein WDR12; WD repeat-containing protein 12
Genbank Nucleotide ID AEFK01133773
Gene Name WDR12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSHAG00000006960.1 ENSSHAT00000008088.1 ENSSHAP00000008024.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.70e-42 140.6 257 293
UBD/Beta-Prp 9.50e-45 153.2 248 414
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvll 36
           gH+d ++++ +sd + ++s+s+D+ti+vWD+ tg+l 
   Q: 257  GHNDAIFSVLWSDaGEICSASWDHTIRVWDVETGNLK 293
           8**********999*******************9875 PP
   

   UBD/Beta-Prp
   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh+d + s+ +s     + s+s+d tirvwd+etg   + tl+g++ + nc++++p ++ l+sG  Dr +rlWd +t++ 
   Q: 248  TRTPIMTLSGHNDAIFSVLWSD-AGEICSASWDHTIRVWDVETGNLKS-TLTGNK-AFNCISYSPLCKRLASGNSDRHIRLWDPRTKDG 333
           6789*****************9.899*********************9.****98.779*************************88764 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ h++ v+s++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v++v+ + +  +l+sg++D+ ++ +
   Q: 334  SLVLlslTS-HNNWVTSVKWSPTHeQQLISGSLDNLVKLWDTRsCKAPLYDLAAHEDKVLCVDWT-EAGLLLSGGADNKLYSY 414
           444444387.************9889*****************54566****************9.999********998876 PP
   
Organism Sarcophilus harrisii
Functional Description
(View)

Functional Description


     Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Protein Sequence
(Fasta)
MAQLQTRFFT TNKKYAVDNV PFSIPAASEI SDLSNIINKL LEAKNEVHKY VEFDFLIKGH 60
FLRMPLIKHM ELENISTEEV VEIEYVEKYI APQPEECIVH DDWISSIEGT EEWILTGSYD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sha-107122|E3,WD_repeat;UBD,Beta-Prp|Sarcophilus harrisii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCCCTCAGC CCTATGGCCG CCGGGAGCCC TGCAGGGCAA CCAGGGAAGT CCGCTAAGCG 60
CCGGAGCCGA GGGGGAGAAA ATTCAAAACG AGTCTACTCA ACCTCGTCTT GGCTCCGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sha-107122|E3,WD_repeat;UBD,Beta-Prp|Sarcophilus harrisii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08154--NLE
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000532 Aegilops tauschii 34.43 3.00e-61 229.00
IUUC-Aml-001997 Ailuropoda melanoleuca 84.31 0.00e+00 676.00
IUUC-Atr-002544 Amborella trichopoda 35.06 4.00e-57 215.00
IUUC-Apl-003981 Anas platyrhynchos 82.40 0.00e+00 628.00
IUUC-Aca-004370 Anolis carolinensis 81.60 0.00e+00 691.00
IUUC-Aly-006455 Arabidopsis lyrata 34.84 1.00e-57 216.00
IUUC-Ath-006669 Arabidopsis thaliana 36.14 5.00e-53 201.00
IUUC-Ago-007864 Ashbya gossypii 28.99 6.00e-36 144.00
IUUC-Acl-008177 Aspergillus clavatus 29.02 3.00e-32 132.00
IUUC-Afl-008617 Aspergillus flavus 28.23 3.00e-31 129.00
IUUC-Afu-008752 Aspergillus fumigatus 28.50 3.00e-28 119.00
IUUC-Ani-009136 Aspergillus nidulans 30.71 2.00e-31 130.00
IUUC-Ang-009701 Aspergillus niger 28.57 1.00e-29 124.00
IUUC-Aor-009884 Aspergillus oryzae 28.47 9.00e-31 127.00
IUUC-Ame-011432 Astyanax mexicanus 74.70 0.00e+00 639.00
IUUC-Bgr-012218 Blumeria graminis 28.54 3.00e-32 132.00
IUUC-Bta-012829 Bos taurus 85.51 0.00e+00 708.00
IUUC-Bci-013953 Botrytis cinerea 28.26 1.00e-31 130.00
IUUC-Bdi-014351 Brachypodium distachyon 36.79 2.00e-58 219.00
IUUC-Bol-016514 Brassica oleracea 35.24 4.00e-53 201.00
IUUC-Bra-016988 Brassica rapa 35.24 8.00e-53 201.00
IUUC-Cel-018569 Caenorhabditis elegans 31.88 1.00e-48 186.00
IUUC-Cja-019468 Callithrix jacchus 83.61 0.00e+00 679.00
IUUC-Cfa-020471 Canis familiaris 84.32 0.00e+00 677.00
IUUC-Cpo-022260 Cavia porcellus 84.32 0.00e+00 688.00
IUUC-Cre-022614 Chlamydomonas reinhardtii 31.08 4.00e-39 155.00
IUUC-Csa-023989 Chlorocebus sabaeus 84.56 0.00e+00 684.00
IUUC-Cho-024426 Choloepus hoffmanni 81.39 5.00e-147 513.00
IUUC-Cin-025789 Ciona intestinalis 41.41 1.00e-94 339.00
IUUC-Cne-027063 Cryptococcus neoformans 24.42 2.00e-22 99.80
IUUC-Dre-027907 Danio rerio 76.36 0.00e+00 657.00
IUUC-Dno-029225 Dasypus novemcinctus 85.04 0.00e+00 705.00
IUUC-Dor-031082 Dipodomys ordii 68.88 8.00e-155 539.00
IUUC-Dse-031308 Dothistroma septosporum 26.55 2.00e-32 132.00
IUUC-Dme-032189 Drosophila melanogaster 39.90 8.00e-89 320.00
IUUC-Ete-032247 Echinops telfairi 79.57 0.00e+00 655.00
IUUC-Eca-034285 Equus caballus 85.04 0.00e+00 705.00
IUUC-Eeu-035322 Erinaceus europaeus 76.00 1.00e-173 602.00
IUUC-Fca-036114 Felis catus 84.32 0.00e+00 699.00
IUUC-Fal-036891 Ficedula albicollis 83.85 2.00e-171 594.00
IUUC-Fox-037965 Fusarium oxysporum 24.41 1.00e-31 130.00
IUUC-Fso-038244 Fusarium solani 25.05 9.00e-32 130.00
IUUC-Gmo-039040 Gadus morhua 74.00 0.00e+00 652.00
IUUC-Gga-040610 Gallus gallus 80.81 0.00e+00 695.00
IUUC-Gac-042117 Gasterosteus aculeatus 73.76 0.00e+00 630.00
IUUC-Gma-043425 Glycine max 37.05 3.00e-62 232.00
IUUC-Ggo-045179 Gorilla gorilla 83.85 0.00e+00 675.00
IUUC-Hsa-046114 Homo sapiens 84.56 0.00e+00 681.00
IUUC-Hvu-047331 Hordeum vulgare 35.04 2.00e-56 213.00
IUUC-Itr-048275 Ictidomys tridecemlineatus 83.85 0.00e+00 696.00
IUUC-Kpa-049304 Komagataella pastoris 29.62 4.00e-39 155.00
IUUC-Lch-050655 Latimeria chalumnae 73.31 9.00e-142 496.00
IUUC-Lpe-051675 Leersia perrieri 36.08 9.00e-62 231.00
IUUC-Loc-052868 Lepisosteus oculatus 80.09 0.00e+00 666.00
IUUC-Lma-053258 Leptosphaeria maculans 27.21 1.00e-30 129.00
IUUC-Laf-053993 Loxodonta africana 83.37 0.00e+00 698.00
IUUC-Mcc-055128 Macaca mulatta 68.65 2.00e-153 535.00
IUUC-Meu-056501 Macropus eugenii 87.20 2.00e-180 624.00
IUUC-Mor-057114 Magnaporthe oryzae 26.00 2.00e-25 110.00
IUUC-Mtr-058367 Medicago truncatula 37.71 1.00e-60 227.00
IUUC-Mla-059107 Melampsora laricipopulina 27.21 6.00e-30 125.00
IUUC-Mga-059745 Meleagris gallopavo 78.77 0.00e+00 669.00
IUUC-Mvi-060362 Microbotryum violaceum 30.09 1.00e-34 140.00
IUUC-Mdo-062257 Monodelphis domestica 91.49 0.00e+00 777.00
IUUC-Mmu-063546 Mus musculus 82.66 0.00e+00 692.00
IUUC-Mac-065540 Musa acuminata 35.00 5.00e-57 214.00
IUUC-Mpu-066284 Mustela putorius furo 85.27 0.00e+00 705.00
IUUC-Mlu-067241 Myotis lucifugus 84.32 0.00e+00 701.00
IUUC-Nfi-068260 Neosartorya fischeri 28.50 6.00e-30 125.00
IUUC-Ncr-068719 Neurospora crassa 26.68 1.00e-27 117.00
IUUC-Nle-068981 Nomascus leucogenys 84.56 0.00e+00 665.00
IUUC-Opr-071218 Ochotona princeps 78.50 2.00e-179 621.00
IUUC-Ont-071646 Oreochromis niloticus 73.76 0.00e+00 657.00
IUUC-Oan-073453 Ornithorhynchus anatinus 84.36 0.00e+00 724.00
IUUC-Ocu-074008 Oryctolagus cuniculus 84.09 0.00e+00 700.00
IUUC-Oba-075712 Oryza barthii 31.44 4.00e-44 171.00
IUUC-Obr-076721 Oryza brachyantha 35.39 2.00e-61 229.00
IUUC-Ogl-077229 Oryza glaberrima 35.92 4.00e-61 228.00
IUUC-Ogu-078977 Oryza glumaepatula 31.44 3.00e-44 172.00
IUUC-Oin-079683 Oryza indica 35.92 2.00e-61 229.00
IUUC-Olo-080291 Oryza longistaminata 31.46 7.00e-30 124.00
IUUC-Ome-081834 Oryza meridionalis 36.15 4.00e-62 232.00
IUUC-Oni-082507 Oryza nivara 34.82 2.00e-57 216.00
IUUC-Opu-083396 Oryza punctata 36.17 1.00e-61 230.00
IUUC-Oru-085220 Oryza rufipogon 34.82 4.00e-57 215.00
IUUC-Osa-085767 Oryza sativa 35.92 2.00e-61 229.00
IUUC-Ola-087420 Oryzias latipes 76.12 0.00e+00 657.00
IUUC-Olu-087740 Ostreococcus lucimarinus 30.12 2.00e-40 159.00
IUUC-Oga-088264 Otolemur garnettii 83.61 0.00e+00 681.00
IUUC-Oar-089335 Ovis aries 85.04 0.00e+00 703.00
IUUC-Ptr-091320 Pan troglodytes 84.56 0.00e+00 681.00
IUUC-Pan-092833 Papio anubis 85.04 0.00e+00 684.00
IUUC-Psi-093504 Pelodiscus sinensis 83.89 0.00e+00 701.00
IUUC-Pma-094189 Petromyzon marinus 68.66 2.00e-169 588.00
IUUC-Pno-094929 Phaeosphaeria nodorum 27.93 2.00e-31 130.00
IUUC-Ppa-095429 Physcomitrella patens 34.91 1.00e-62 233.00
IUUC-Pfo-096337 Poecilia formosa 74.23 0.00e+00 661.00
IUUC-Pab-097571 Pongo abelii 84.09 0.00e+00 679.00
IUUC-Pop-099977 Populus trichocarpa 37.47 7.00e-67 247.00
IUUC-Pca-100394 Procavia capensis 79.36 6.00e-178 616.00
IUUC-Ppe-101848 Prunus persica 36.45 4.00e-62 231.00
IUUC-Pva-102921 Pteropus vampyrus 83.13 2.00e-106 378.00
IUUC-Pgr-103637 Puccinia graminis 28.60 3.00e-34 139.00
IUUC-Ptt-103781 Puccinia triticina 28.36 6.00e-34 138.00
IUUC-Pte-104135 Pyrenophora teres 26.67 2.00e-31 131.00
IUUC-Pyt-104609 Pyrenophora triticirepentis 26.27 8.00e-31 127.00
IUUC-Rno-105114 Rattus norvegicus 82.19 0.00e+00 691.00
IUUC-Sce-106401 Saccharomyces cerevisiae 28.67 9.00e-37 147.00
IUUC-Sja-107766 Schizosaccharomyces japonicus 32.09 8.00e-49 187.00
IUUC-Spo-108134 Schizosaccharomyces pombe 29.93 3.00e-40 159.00
IUUC-Smo-108720 Selaginella moellendorffii 33.33 6.00e-58 218.00
IUUC-Sit-110311 Setaria italica 37.24 3.00e-61 228.00
IUUC-Sly-111178 Solanum lycopersicum 34.24 1.00e-55 210.00
IUUC-Stu-112778 Solanum tuberosum 35.71 1.00e-59 223.00
IUUC-Sar-113596 Sorex araneus 71.26 2.00e-157 548.00
IUUC-Sbi-114193 Sorghum bicolor 36.13 1.00e-59 223.00
IUUC-Sre-115002 Sporisorium reilianum 25.53 1.00e-13 71.20
IUUC-Ssc-116066 Sus scrofa 85.27 0.00e+00 704.00
IUUC-Tgu-117048 Taeniopygia guttata 82.67 0.00e+00 629.00
IUUC-Tsy-119573 Tarsius syrichta 54.33 4.00e-114 404.00
IUUC-Tni-119820 Tetraodon nigroviridis 74.70 0.00e+00 661.00
IUUC-Tca-121605 Theobroma cacao 36.75 9.00e-61 227.00
IUUC-Tre-121947 Trichoderma reesei 25.34 2.00e-31 130.00
IUUC-Tvi-122481 Trichoderma virens 26.01 3.00e-33 135.00
IUUC-Tae-125861 Triticum aestivum 34.67 2.00e-61 229.00
IUUC-Tur-126586 Triticum urartu 35.29 6.00e-59 221.00
IUUC-Tme-126900 Tuber melanosporum 30.12 3.00e-46 179.00
IUUC-Tbe-127736 Tupaia belangeri 64.50 4.00e-135 474.00
IUUC-Ttr-129041 Tursiops truncatus 75.30 9.00e-175 605.00
IUUC-Vpa-130260 Vicugna pacos 85.04 0.00e+00 705.00
IUUC-Vvi-131009 Vitis vinifera 37.18 9.00e-61 227.00
IUUC-Xtr-132083 Xenopus tropicalis 77.49 0.00e+00 655.00
IUUC-Xma-133094 Xiphophorus maculatus 72.81 0.00e+00 649.00
IUUC-Yli-134531 Yarrowia lipolytica 23.66 2.00e-15 77.40
IUUC-Zma-135509 Zea mays 34.04 8.00e-61 227.00
Created Date 25-Jun-2017

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