iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-097075

Ensembl Protein ID

ENSPFOP00000018511.2

UniProt Accession

A0A087YKF8; A0A087YKF8_POEFO

Genbank Protein ID

ENSPFOP00000018511

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AYCK01018986

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000018359.2	ENSPFOT00000018533.2	ENSPFOP00000018511.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-119	400.0	2104	2572

Active Site

Position(s)	Description	Evidence
2541	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg++l++++  d+e++q++   glk+p                     
   Q: 2104 HADRKSVLEVEFQGEEGTGL-GPTLEFYALVAAEFQRTSLGIWLCDDDfpDDESRQVDLGGGLKPPgfyvqrscglfpapfpqdsee 2189
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp s++f+kll                                                  
   Q: 2190 leRITKLFHFLGIFLAKCIQDNRLVDLPVSQPFFKLLcmgdiksnmskllyqsrgsppghgperahlqallsevqseasteesqety 2276
           *************************************************99999999999999999999999999999999988888 PP
   S: 101  .........................lgkklsledleevdpelykslkeikena.......es......................... 130
                                     +  l+++d++ v+p+++ +lke+ke+a        s                         
   Q: 2277 svgsfdedsksefimdppkrklpawYHGILTWDDFQLVNPHRATFLKEVKELAvkrrqilGSkslsedekntrlqdlmlrnpmgsgp 2363
           88888888777777666666655555557***********************976665550055666777889999999999999** PP
   S: 131  ..dieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeele 215
             +ie+lgl+++f++s+++ g  +++ Lk++G++++Vt eN+eeYv+l++++++++gi++q+eaf+eGfn+v+p+e+ls+F+++e++
   Q: 2364 plSIEDLGLNFQFCPSSKVHGFSAVD-LKSNGDDEMVTVENAEEYVELMFDFCMHTGIQKQMEAFKEGFNQVFPMEKLSSFSHKEVQ 2449
           ****************9988888777.************************************************************ PP
   S: 216  llicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlP 299
           +++cG+  ++++++d+ + t+ k gyt+dsp++q+F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+d+++P
   Q: 2450 MVLCGNqsPSWNADDIINYTEPKLGYTRDSPGFQRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDATDSSYP 2536
           ******7777888888888888***************************************************************** PP
   S: 300  ssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           s+nTC++yLkLPeYss++i++e+Ll+A++e kgF+l+
   Q: 2537 SVNTCVHYLKLPEYSSEDIMRERLLAATME-KGFHLN 2572
           ******************************.****86 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGATATTTCC GAGCTCTACC GTGACACTGA ACACCACAGA CTTAACTCGG CTATTGCGTT 60
CAGTCGGGTC AGCTAAGCGC ACCCCGTCAC TCTGTTTTGT GACCCGCTTG AGTAGGAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	85.18	0.00e+00	2547.00
IUUC-Apl-003493	Anas platyrhynchos	85.11	0.00e+00	2545.00
IUUC-Aca-004521	Anolis carolinensis	85.61	0.00e+00	2781.00
IUUC-Ame-011258	Astyanax mexicanus	95.72	0.00e+00	2407.00
IUUC-Bta-012835	Bos taurus	85.00	0.00e+00	2552.00
IUUC-Cel-018153	Caenorhabditis elegans	52.24	1.00e-172	602.00
IUUC-Cja-019174	Callithrix jacchus	83.90	0.00e+00	2480.00
IUUC-Cfa-021115	Canis familiaris	84.77	0.00e+00	2497.00
IUUC-Cpo-022382	Cavia porcellus	79.32	0.00e+00	2313.00
IUUC-Csa-023230	Chlorocebus sabaeus	85.12	0.00e+00	2547.00
IUUC-Cho-024711	Choloepus hoffmanni	75.03	0.00e+00	1269.00
IUUC-Cin-025342	Ciona intestinalis	52.91	0.00e+00	1352.00
IUUC-Csv-026031	Ciona savignyi	52.11	0.00e+00	1398.00
IUUC-Dre-027435	Danio rerio	92.96	0.00e+00	2487.00
IUUC-Dno-029954	Dasypus novemcinctus	85.12	0.00e+00	2544.00
IUUC-Dor-030734	Dipodomys ordii	88.86	0.00e+00	1338.00
IUUC-Dme-031739	Drosophila melanogaster	59.50	0.00e+00	1613.00
IUUC-Ete-033192	Echinops telfairi	85.06	0.00e+00	1130.00
IUUC-Eca-033434	Equus caballus	84.47	0.00e+00	2517.00
IUUC-Eeu-035031	Erinaceus europaeus	77.59	0.00e+00	1002.00
IUUC-Fca-035998	Felis catus	92.81	0.00e+00	2319.00
IUUC-Fal-037468	Ficedula albicollis	81.70	0.00e+00	3811.00
IUUC-Gmo-038495	Gadus morhua	92.19	0.00e+00	1371.00
IUUC-Gga-040736	Gallus gallus	82.77	0.00e+00	3821.00
IUUC-Gac-041777	Gasterosteus aculeatus	95.53	0.00e+00	2449.00
IUUC-Ggo-044677	Gorilla gorilla	81.20	0.00e+00	2375.00
IUUC-Hsa-045879	Homo sapiens	85.12	0.00e+00	2547.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	85.00	0.00e+00	2548.00
IUUC-Lch-050444	Latimeria chalumnae	83.91	0.00e+00	2479.00
IUUC-Loc-051986	Lepisosteus oculatus	94.88	0.00e+00	2359.00
IUUC-Laf-054230	Loxodonta africana	84.40	0.00e+00	2518.00
IUUC-Mcc-054787	Macaca mulatta	85.12	0.00e+00	2547.00
IUUC-Meu-056502	Macropus eugenii	83.39	0.00e+00	1025.00
IUUC-Mga-059409	Meleagris gallopavo	93.09	0.00e+00	1872.00
IUUC-Mmr-061667	Microcebus murinus	83.99	0.00e+00	2521.00
IUUC-Mdo-061960	Monodelphis domestica	84.50	0.00e+00	2532.00
IUUC-Mmu-063941	Mus musculus	84.24	0.00e+00	2509.00
IUUC-Mpu-065939	Mustela putorius furo	85.12	0.00e+00	2546.00
IUUC-Mlu-068112	Myotis lucifugus	84.94	0.00e+00	2545.00
IUUC-Nle-069001	Nomascus leucogenys	85.12	0.00e+00	2547.00
IUUC-Opr-071222	Ochotona princeps	88.78	0.00e+00	1987.00
IUUC-Ont-072101	Oreochromis niloticus	90.95	0.00e+00	4180.00
IUUC-Oan-072814	Ornithorhynchus anatinus	84.94	0.00e+00	2546.00
IUUC-Ocu-074011	Oryctolagus cuniculus	85.18	0.00e+00	2547.00
IUUC-Ola-086412	Oryzias latipes	92.86	0.00e+00	2740.00
IUUC-Oar-089668	Ovis aries	85.00	0.00e+00	2546.00
IUUC-Ptr-090517	Pan troglodytes	84.62	0.00e+00	2511.00
IUUC-Pan-091849	Papio anubis	82.05	0.00e+00	2415.00
IUUC-Psi-093390	Pelodiscus sinensis	92.58	0.00e+00	2296.00
IUUC-Pma-094628	Petromyzon marinus	82.46	0.00e+00	1571.00
IUUC-Ppa-095264	Physcomitrella patens	32.50	8.00e-81	296.00
IUUC-Pab-098176	Pongo abelii	85.12	0.00e+00	2547.00
IUUC-Pca-101123	Procavia capensis	71.15	0.00e+00	1184.00
IUUC-Pva-103008	Pteropus vampyrus	93.96	0.00e+00	1509.00
IUUC-Rno-105885	Rattus norvegicus	84.83	0.00e+00	2538.00
IUUC-Sha-107048	Sarcophilus harrisii	84.27	0.00e+00	2515.00
IUUC-Sar-113071	Sorex araneus	88.34	0.00e+00	1204.00
IUUC-Ssc-115963	Sus scrofa	85.18	0.00e+00	2543.00
IUUC-Tgu-117488	Taeniopygia guttata	93.84	0.00e+00	1301.00
IUUC-Tru-118626	Takifugu rubripes	91.32	0.00e+00	2731.00
IUUC-Tsy-119504	Tarsius syrichta	80.33	0.00e+00	1992.00
IUUC-Tni-119877	Tetraodon nigroviridis	90.60	0.00e+00	2663.00
IUUC-Tbe-127602	Tupaia belangeri	86.01	0.00e+00	985.00
IUUC-Ttr-128394	Tursiops truncatus	76.06	0.00e+00	1291.00
IUUC-Vpa-130280	Vicugna pacos	84.71	0.00e+00	2529.00
IUUC-Xtr-131787	Xenopus tropicalis	89.71	0.00e+00	2340.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence