iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-16	60.1	80	112

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDl 30
           gHt++v ++++   +d  ++sGs D+t++vW +
   Q: 80   GHTGPVLDIDWcphNDEVIASGSEDCTVMVWQI 112
           8***********977799*************75 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV IVEASGGGAF 60
MVLPLNKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS GSEDCTVMVW QIPENGLTSP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTCACTTC CTGATTCCCG CTTCCTGCTT CCCAGAGGCC GGGATCCGGA GCCGCCCGAG 60
GTCGCCGCCG CAGTCCCCGG CGCCCCTGGG GAGCGGAGAG CGGTGAGCGG TGAGCGGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015505--Coronin
IPR015048--DUF1899
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0001725--C:stress fiber
GO:0090135--P:actin filament branching
GO:0051017--P:actin filament bundle assembly
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0035767--P:endothelial cell chemotaxis
GO:0034316--P:negative regulation of Arp2/3 complex-mediated actin nucleation
GO:0071672--P:negative regulation of smooth muscle cell chemotaxis
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:1902463--P:protein localization to cell leading edge
GO:0031529--P:ruffle organization
GO:0042060--P:wound healing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002423	Ailuropoda melanoleuca	92.62	0.00e+00	936.00
IUUC-Aca-005056	Anolis carolinensis	80.65	0.00e+00	815.00
IUUC-Bta-012984	Bos taurus	92.18	0.00e+00	929.00
IUUC-Cja-019498	Callithrix jacchus	92.24	0.00e+00	919.00
IUUC-Cfa-020937	Canis familiaris	93.88	0.00e+00	859.00
IUUC-Cpo-021866	Cavia porcellus	91.51	0.00e+00	901.00
IUUC-Csa-023561	Chlorocebus sabaeus	92.02	0.00e+00	927.00
IUUC-Csv-026184	Ciona savignyi	41.31	6.00e-87	314.00
IUUC-Dno-029770	Dasypus novemcinctus	86.50	0.00e+00	861.00
IUUC-Dor-030989	Dipodomys ordii	90.53	0.00e+00	905.00
IUUC-Eca-033901	Equus caballus	92.64	0.00e+00	915.00
IUUC-Fca-036494	Felis catus	91.62	0.00e+00	886.00
IUUC-Fal-036737	Ficedula albicollis	81.35	0.00e+00	834.00
IUUC-Ggo-045035	Gorilla gorilla	93.46	0.00e+00	931.00
IUUC-Hsa-046154	Homo sapiens	93.25	0.00e+00	928.00
IUUC-Itr-048847	Ictidomys tridecemlineatus	90.74	0.00e+00	908.00
IUUC-Laf-054566	Loxodonta africana	89.32	0.00e+00	890.00
IUUC-Mcc-054879	Macaca mulatta	92.43	0.00e+00	927.00
IUUC-Mmr-060910	Microcebus murinus	91.74	0.00e+00	923.00
IUUC-Mmu-063455	Mus musculus	97.52	0.00e+00	989.00
IUUC-Mpu-066350	Mustela putorius furo	91.82	0.00e+00	922.00
IUUC-Mlu-067353	Myotis lucifugus	92.58	0.00e+00	914.00
IUUC-Nle-069161	Nomascus leucogenys	92.84	0.00e+00	918.00
IUUC-Opr-071106	Ochotona princeps	90.53	0.00e+00	900.00
IUUC-Oga-088805	Otolemur garnettii	91.19	0.00e+00	926.00
IUUC-Ptr-091484	Pan troglodytes	93.25	0.00e+00	928.00
IUUC-Pan-091843	Papio anubis	92.02	0.00e+00	919.00
IUUC-Pab-097835	Pongo abelii	93.25	0.00e+00	927.00
IUUC-Pca-100411	Procavia capensis	80.45	0.00e+00	788.00
IUUC-Pva-102659	Pteropus vampyrus	92.23	0.00e+00	920.00
IUUC-Sha-106609	Sarcophilus harrisii	93.80	0.00e+00	714.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence