iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000012317.3	ENSCJAT00000024105.2	ENSCJAP00000022783.2
ENSCJAG00000012317.3	ENSCJAT00000024032.2	ENSCJAP00000022716.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-80	270.3	2652	3012

Active Site

Position(s)	Description	Evidence
2986	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 2652 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 2734
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + 
   Q: 2735 ADVPLPLDLLPSFWKTLVGEPLDPeQDLQEADILTYNYvKKFESINDETELEALCAEIASQhlA--TEspdspnkpccrftylTMTG 2819
           ************************9*************56666677789999999999999532..33468999*******655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++i V++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+ ++ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 2820 EEVELCSRGRHILVAWENKDIYAAAIRSLRLRElQNVECVTAVRAGLGSIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 2906
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 2907 GLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 2993
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 2994 QYSSLEIMLEKLRCAIHYR 3012
           ****************986 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MPFFYDYHFN ENKMKELELL CSMKEVSFDG NDLENMVLSL REKFLQEVNS LIQKPLHPLA 60
KTKTLVKSLM NRAELLLHVT IAAQSGLTRS ISGTPAETPA CKSASETKVI SPAVRQPVFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGCCAGG TGGTACCAAT GCCAGCCAAT CACCTCCCCA TTGGCAGCAC CATGAGCACT 60
GTGCACCTGT CTTCAGATGG CACTTACTTC TATTGGATCT GGTCTCCTGC CAGCCTGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	97.33	0.00e+00	3447.00
IUUC-Apl-004161	Anas platyrhynchos	91.68	0.00e+00	5122.00
IUUC-Aca-005341	Anolis carolinensis	90.15	0.00e+00	5039.00
IUUC-Ame-011574	Astyanax mexicanus	83.20	0.00e+00	3009.00
IUUC-Bta-012514	Bos taurus	95.52	0.00e+00	1941.00
IUUC-Cfa-020499	Canis familiaris	97.33	0.00e+00	3464.00
IUUC-Cpo-021894	Cavia porcellus	96.98	0.00e+00	2753.00
IUUC-Csa-023079	Chlorocebus sabaeus	98.05	0.00e+00	5382.00
IUUC-Cho-024415	Choloepus hoffmanni	93.67	0.00e+00	3259.00
IUUC-Dre-027452	Danio rerio	81.71	0.00e+00	3031.00
IUUC-Dno-029595	Dasypus novemcinctus	95.63	0.00e+00	5318.00
IUUC-Dor-030849	Dipodomys ordii	88.93	0.00e+00	1513.00
IUUC-Ete-032563	Echinops telfairi	90.35	0.00e+00	1176.00
IUUC-Eca-034202	Equus caballus	97.23	0.00e+00	3422.00
IUUC-Eeu-035175	Erinaceus europaeus	97.11	0.00e+00	1076.00
IUUC-Fca-036295	Felis catus	95.99	0.00e+00	5308.00
IUUC-Fal-037003	Ficedula albicollis	91.48	0.00e+00	4356.00
IUUC-Gmo-038579	Gadus morhua	84.11	0.00e+00	2828.00
IUUC-Gga-040961	Gallus gallus	91.59	0.00e+00	5129.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.12	0.00e+00	2876.00
IUUC-Ggo-045099	Gorilla gorilla	98.24	0.00e+00	5457.00
IUUC-Hsa-046331	Homo sapiens	98.11	0.00e+00	5433.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	96.00	0.00e+00	2156.00
IUUC-Lch-049923	Latimeria chalumnae	90.26	0.00e+00	1155.00
IUUC-Loc-052630	Lepisosteus oculatus	82.83	0.00e+00	4010.00
IUUC-Laf-053394	Loxodonta africana	96.74	0.00e+00	3439.00
IUUC-Mcc-055763	Macaca mulatta	98.08	0.00e+00	5386.00
IUUC-Meu-056039	Macropus eugenii	87.88	0.00e+00	4839.00
IUUC-Mga-059500	Meleagris gallopavo	91.37	0.00e+00	5122.00
IUUC-Mmr-060868	Microcebus murinus	91.77	0.00e+00	5058.00
IUUC-Mdo-062772	Monodelphis domestica	92.95	0.00e+00	5185.00
IUUC-Mmu-063606	Mus musculus	96.69	0.00e+00	3458.00
IUUC-Mpu-065860	Mustela putorius furo	94.78	0.00e+00	3358.00
IUUC-Mlu-067376	Myotis lucifugus	96.53	0.00e+00	3441.00
IUUC-Nle-069693	Nomascus leucogenys	96.10	0.00e+00	5298.00
IUUC-Ont-072470	Oreochromis niloticus	83.06	0.00e+00	3022.00
IUUC-Oan-073693	Ornithorhynchus anatinus	94.49	0.00e+00	3370.00
IUUC-Ocu-074032	Oryctolagus cuniculus	95.50	0.00e+00	5295.00
IUUC-Ola-087433	Oryzias latipes	83.03	0.00e+00	1452.00
IUUC-Oga-088546	Otolemur garnettii	96.72	0.00e+00	5355.00
IUUC-Oar-089643	Ovis aries	91.89	0.00e+00	765.00
IUUC-Ptr-090504	Pan troglodytes	98.11	0.00e+00	5436.00
IUUC-Pan-092543	Papio anubis	98.05	0.00e+00	5388.00
IUUC-Psi-093952	Pelodiscus sinensis	89.51	0.00e+00	5022.00
IUUC-Pfo-096356	Poecilia formosa	80.78	0.00e+00	4678.00
IUUC-Pab-098240	Pongo abelii	98.01	0.00e+00	5383.00
IUUC-Pca-100994	Procavia capensis	98.04	0.00e+00	1712.00
IUUC-Pva-102263	Pteropus vampyrus	95.09	0.00e+00	3353.00
IUUC-Rno-104888	Rattus norvegicus	95.30	0.00e+00	5282.00
IUUC-Sha-106944	Sarcophilus harrisii	92.00	0.00e+00	5208.00
IUUC-Sar-113556	Sorex araneus	80.58	0.00e+00	984.00
IUUC-Ssc-116187	Sus scrofa	96.78	0.00e+00	5132.00
IUUC-Tgu-116655	Taeniopygia guttata	90.54	0.00e+00	5023.00
IUUC-Tru-118093	Takifugu rubripes	82.69	0.00e+00	2959.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.26	0.00e+00	1486.00
IUUC-Tbe-127962	Tupaia belangeri	91.86	0.00e+00	1222.00
IUUC-Ttr-128819	Tursiops truncatus	91.25	0.00e+00	2847.00
IUUC-Vpa-130482	Vicugna pacos	95.40	0.00e+00	2621.00
IUUC-Xtr-132222	Xenopus tropicalis	87.16	0.00e+00	5014.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence