iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066196

Ensembl Protein ID

ENSMPUP00000005274.1

UniProt Accession

M3Y1S3; M3Y1S3_MUSPF

Genbank Protein ID

ENSMPUP00000005274

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01081420

Gene Name

ATG16L1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000005312.1	ENSMPUT00000005362.1	ENSMPUP00000005274.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-30	103.8	422	461
UBD/Beta-Prp	9.60e-63	212.1	331	621

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllks 38
           gH+++v + +f  ++ ++vsGs+D t+k+WDlr+ v++k+
   Q: 422  GHSGKVLSAKFllDNARIVSGSHDRTLKLWDLRSKVCIKT 461
           8***********64489********************985 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvht 89
            +++++h++ +++v+fsp+++llatg++d+++k+w+v+  k+    slsg +a++t+++f++ g++l+ +s+D + ++w ++++   ht
   Q: 331  MCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGDKCefKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHT 419
           57899************************************9999******************************************** PP
   S: 90   lkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
           l+gh+ +vls +f  ++ ++vsGshdrt+++wdl+++ c++++++g +    c  + +++++++sG+ D+++r+Wd+++++++r+++  
   Q: 420  LTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS----CNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREME-- 502
           *****************************************9999988....888888889*************************6.. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght....dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlh 263
             ++++ l+++++++el+s+s+d  +k+ dl+ + + +t+ +      +  ++v fsp++ +++ gs++gs+++W + sg++ k+l+++
   Q: 503  LLGKITALDLNPERTELLSCSRDDLLKIIDLRINAVRQTFSAPGfkcgSDWTRVVFSPDGGYVAAGSAEGSLYVWSVLSGKVEKVLSKQ 591
           69******************************9999999998887888777779*********************************** PP
   S: 264  nssvisvavlsfgdnvlvlgsedskvniwk 293
           + s+i   ++s++++++v++++ sk+ +w+
   Q: 592  HGSSINAVAWSPSGSHVVSVDKGSKAVLWS 621
           *999999999******************97 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MSSGLRAADF PRWKRHISEE LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAHKLQAEK 60
HDIPNRHEIS PGHDAAWNDS QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQQK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCGGCAGG AGCCGGAAGA CGGTCCCTGA CGGCATTGGC GGCGGCCTGT GCGTGGTAGT 60
GTGCTCTGGG CCGCCGGTTT TCCGGCGTCC GCTGGTAGCC GATGCTGCGG TCCGGGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR013923--Autophagy-rel_prot_16
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08614--ATG16
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0005930--C:axoneme
GO:0039689--P:negative stranded viral RNA replication

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000090	Aegilops tauschii	28.37	8.00e-33	135.00
IUUC-Aml-002242	Ailuropoda melanoleuca	87.58	0.00e+00	1069.00
IUUC-Atr-003073	Amborella trichopoda	28.71	1.00e-26	114.00
IUUC-Apl-003384	Anas platyrhynchos	86.00	0.00e+00	1059.00
IUUC-Aca-004962	Anolis carolinensis	87.16	0.00e+00	1075.00
IUUC-Aly-005435	Arabidopsis lyrata	33.99	4.00e-45	175.00
IUUC-Ath-006948	Arabidopsis thaliana	34.32	8.00e-46	177.00
IUUC-Ame-010915	Astyanax mexicanus	79.75	7.00e-154	536.00
IUUC-Bta-012388	Bos taurus	96.15	0.00e+00	1192.00
IUUC-Bdi-014231	Brachypodium distachyon	28.88	7.00e-37	148.00
IUUC-Bol-016174	Brassica oleracea	34.65	2.00e-45	176.00
IUUC-Bra-017165	Brassica rapa	33.99	1.00e-44	174.00
IUUC-Cel-018131	Caenorhabditis elegans	30.49	2.00e-62	233.00
IUUC-Cja-018898	Callithrix jacchus	83.31	0.00e+00	982.00
IUUC-Cfa-020484	Canis familiaris	96.15	0.00e+00	1180.00
IUUC-Cpo-022156	Cavia porcellus	91.30	0.00e+00	1111.00
IUUC-Csa-024019	Chlorocebus sabaeus	90.69	0.00e+00	1105.00
IUUC-Cho-024311	Choloepus hoffmanni	81.09	0.00e+00	976.00
IUUC-Cin-025260	Ciona intestinalis	36.48	3.00e-97	349.00
IUUC-Csv-025836	Ciona savignyi	45.41	5.00e-48	183.00
IUUC-Dre-027702	Danio rerio	75.00	0.00e+00	890.00
IUUC-Dno-029728	Dasypus novemcinctus	94.55	0.00e+00	1196.00
IUUC-Dor-030587	Dipodomys ordii	82.78	4.00e-121	428.00
IUUC-Dme-031595	Drosophila melanogaster	38.16	2.00e-106	379.00
IUUC-Ete-032969	Echinops telfairi	74.32	0.00e+00	771.00
IUUC-Eca-034214	Equus caballus	94.49	0.00e+00	955.00
IUUC-Eeu-034537	Erinaceus europaeus	87.94	0.00e+00	902.00
IUUC-Fca-036005	Felis catus	97.29	0.00e+00	1132.00
IUUC-Fal-037593	Ficedula albicollis	88.08	0.00e+00	1041.00
IUUC-Gmo-039042	Gadus morhua	63.40	0.00e+00	672.00
IUUC-Gga-040986	Gallus gallus	88.28	0.00e+00	1102.00
IUUC-Gac-041351	Gasterosteus aculeatus	72.88	0.00e+00	904.00
IUUC-Gma-043452	Glycine max	33.66	4.00e-46	179.00
IUUC-Ggo-045427	Gorilla gorilla	94.39	0.00e+00	1159.00
IUUC-Hsa-046632	Homo sapiens	92.78	0.00e+00	1145.00
IUUC-Itr-048504	Ictidomys tridecemlineatus	89.26	0.00e+00	1087.00
IUUC-Lpe-051254	Leersia perrieri	29.72	1.00e-36	147.00
IUUC-Loc-052610	Lepisosteus oculatus	76.33	0.00e+00	937.00
IUUC-Laf-053936	Loxodonta africana	92.79	0.00e+00	1149.00
IUUC-Mcc-055504	Macaca mulatta	91.68	0.00e+00	1175.00
IUUC-Meu-056516	Macropus eugenii	86.06	0.00e+00	1029.00
IUUC-Mtr-058062	Medicago truncatula	32.01	2.00e-42	167.00
IUUC-Mga-059777	Meleagris gallopavo	83.60	0.00e+00	1050.00
IUUC-Mmr-061298	Microcebus murinus	96.79	0.00e+00	1175.00
IUUC-Mdo-062969	Monodelphis domestica	90.22	0.00e+00	1105.00
IUUC-Mmu-064076	Mus musculus	93.73	0.00e+00	1129.00
IUUC-Mac-065022	Musa acuminata	31.46	7.00e-40	157.00
IUUC-Mlu-067651	Myotis lucifugus	93.59	0.00e+00	1145.00
IUUC-Nle-069853	Nomascus leucogenys	91.81	0.00e+00	1126.00
IUUC-Opr-070350	Ochotona princeps	94.04	2.00e-119	422.00
IUUC-Ont-072489	Oreochromis niloticus	73.08	0.00e+00	887.00
IUUC-Oan-072703	Ornithorhynchus anatinus	85.39	0.00e+00	1004.00
IUUC-Ocu-074205	Oryctolagus cuniculus	92.94	0.00e+00	1159.00
IUUC-Oba-075619	Oryza barthii	29.82	2.00e-35	143.00
IUUC-Obr-076632	Oryza brachyantha	29.21	3.00e-36	146.00
IUUC-Ogl-077671	Oryza glaberrima	29.82	2.00e-35	143.00
IUUC-Ogu-078052	Oryza glumaepatula	29.82	2.00e-35	143.00
IUUC-Oin-079611	Oryza indica	29.47	1.00e-33	137.00
IUUC-Olo-080408	Oryza longistaminata	29.82	4.00e-35	142.00
IUUC-Ome-081560	Oryza meridionalis	29.82	2.00e-35	143.00
IUUC-Oni-082145	Oryza nivara	29.82	2.00e-35	143.00
IUUC-Opu-083918	Oryza punctata	29.47	1.00e-34	141.00
IUUC-Oru-084858	Oryza rufipogon	29.47	2.00e-33	137.00
IUUC-Osa-086277	Oryza sativa	29.47	1.00e-33	137.00
IUUC-Ola-086816	Oryzias latipes	70.22	5.00e-100	357.00
IUUC-Olu-087622	Ostreococcus lucimarinus	33.11	2.00e-43	169.00
IUUC-Oga-088765	Otolemur garnettii	90.06	0.00e+00	1051.00
IUUC-Oar-090196	Ovis aries	92.39	0.00e+00	1038.00
IUUC-Ptr-091676	Pan troglodytes	92.94	0.00e+00	1147.00
IUUC-Pan-092068	Papio anubis	95.35	0.00e+00	1165.00
IUUC-Psi-093367	Pelodiscus sinensis	85.39	0.00e+00	1043.00
IUUC-Ppa-095699	Physcomitrella patens	33.78	4.00e-40	159.00
IUUC-Pfo-096067	Poecilia formosa	71.19	0.00e+00	868.00
IUUC-Pab-098111	Pongo abelii	94.39	0.00e+00	1158.00
IUUC-Pop-099116	Populus trichocarpa	31.68	3.00e-42	166.00
IUUC-Pca-100680	Procavia capensis	83.81	0.00e+00	956.00
IUUC-Ppe-101790	Prunus persica	31.46	1.00e-43	171.00
IUUC-Pva-102871	Pteropus vampyrus	93.69	0.00e+00	1089.00
IUUC-Rno-106088	Rattus norvegicus	93.25	0.00e+00	1127.00
IUUC-Sha-106984	Sarcophilus harrisii	88.03	0.00e+00	1071.00
IUUC-Smo-109404	Selaginella moellendorffii	32.11	5.00e-42	165.00
IUUC-Sit-110828	Setaria italica	31.53	1.00e-39	157.00
IUUC-Sly-111009	Solanum lycopersicum	31.68	3.00e-45	176.00
IUUC-Stu-112370	Solanum tuberosum	31.68	6.00e-46	178.00
IUUC-Sar-113659	Sorex araneus	61.54	9.00e-92	329.00
IUUC-Sbi-114819	Sorghum bicolor	30.58	2.00e-37	150.00
IUUC-Ssc-116241	Sus scrofa	91.18	0.00e+00	1110.00
IUUC-Tgu-116576	Taeniopygia guttata	86.36	0.00e+00	1091.00
IUUC-Tru-118336	Takifugu rubripes	65.14	0.00e+00	743.00
IUUC-Tsy-119006	Tarsius syrichta	91.97	0.00e+00	1107.00
IUUC-Tni-120300	Tetraodon nigroviridis	72.88	0.00e+00	865.00
IUUC-Tca-121002	Theobroma cacao	33.78	6.00e-45	175.00
IUUC-Tae-124868	Triticum aestivum	29.07	9.00e-34	138.00
IUUC-Tur-126463	Triticum urartu	28.37	3.00e-33	136.00
IUUC-Tbe-127631	Tupaia belangeri	92.29	0.00e+00	912.00
IUUC-Ttr-129005	Tursiops truncatus	86.69	2.00e-166	578.00
IUUC-Vpa-130246	Vicugna pacos	88.19	0.00e+00	883.00
IUUC-Vvi-130878	Vitis vinifera	33.65	4.00e-43	169.00
IUUC-Xtr-132798	Xenopus tropicalis	72.13	0.00e+00	861.00
IUUC-Xma-133264	Xiphophorus maculatus	70.70	0.00e+00	861.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence