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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105853
UUCD1 version UUC-RaN-01073
Ensembl Protein ID ENSRNOP00000009975.3
UniProt Accession Q5U349; Q9QXL3; Q9QXL4; Q9R083; Q9R084; UBP2_RAT
Genbank Protein ID AAF17574.1; AAF17575.1; AAF14189.1; AAF14190.1; EDL95274.1; EDL95276.1; EDL95277.1; AAH85719.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2; Ubiquitin-specific-processing protease testis
Genbank Nucleotide ID AF202453; AF202454; AF106658; AF106659; CH473975; CH473975; CH473975; BC085719
Gene Name Usp2; Ubp41; Ubp69
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000006663.8 ENSRNOT00000009975.7 ENSRNOP00000009975.3
ENSRNOG00000006663.8 ENSRNOT00000036051.6 ENSRNOP00000030257.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IIDHINTMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 8.90e-98 328.0 281 610
Active Site
Position(s) Description Evidence
289 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
570 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           Gl+NlgNtC+mNS+LQcLsn++elr+++l+  + ++l ++  ++ +++l+++++kl++ +w +s + +vsp+e++++++++a++f gy+
   Q: 281  GLRNLGNTCFMNSILQCLSNTRELRDYCLQrLYMRDLGHT--SSAHTALMEEFAKLIQTIWtSSPNDVVSPSEFKTQIQRYAPRFVGYN 367
           9*****************************7788888877..7899***************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkk...eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           qqDaqEfl+flld+l++e+++   + + + e++ +  ++e+ ++ ++k  ++++s i dlF gqlks+++c +c+  s+ ++pf+dlsl
   Q: 368  QQDAQEFLRFLLDGLHNEVNRvaaRPKPSPESLDHLPDEEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSL 456
           *******************99553222233333344445555559******************************************** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldls 262
           p+ ++    + +l dc++ ftke+ l+g++k  c +c++++++ kk++++++P++L+lhLkRf  se++ + +k+++ v+fpl+ Ldl+
   Q: 457  PIAKRGYP-EVTLMDCMRLFTKEDVLDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHLKRF--SESRIRTSKLTTFVNFPLRdLDLR 542
           ****9976.779***************************************************..88899******************* PP
   S: 263  pfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           +f +++++    +  Y+L+av +HsG++ +GHY+ay+++  +g+W +f+Ds+Vt+++ ++v +   s+aY+lfY+
   Q: 543  EFASENTN----HAVYNLYAVSNHSGTTMGGHYTAYCRSpVTGEWHTFNDSSVTPMSSSQVRT---SDAYLLFYE 610
           ****9553....78*************************44666*******************...********8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells (By similarity). Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (PubMed:23213472). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1.
 Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells (By similarity). Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (PubMed:23213472). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1.
Protein Sequence
(Fasta)
MSQLSSTLKR YTESSRYTDA PYAKSGYGTY TPSSYGANLA ASFLEKEKLG FKPVSPTSFL 60
PRPRTYGPSS ILDCDRGRPL LRSDITGGSK RSESQTRGNE RPSGSGLNGG SGFPYGVTSN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105853|DUB,USP|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGGGTTAGC AGTTTGGCCT CTTCGTGTTC GCTCAACTTG TGACGGACAG CACTAGAGAA 60
TCCACCTTCT CCATGTCTGG GACTCAGACT CATCCCCAGC CCTCTGCTCT GACCCCTGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105853|DUB,USP|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0517--Myogenesis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007049--P:cell cycle
GO:0048512--P:circadian behavior
GO:0032922--P:circadian regulation of gene expression
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0045475--P:locomotor rhythm
GO:0007517--P:muscle organ development
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0048643--P:positive regulation of skeletal muscle tissue development
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG rno:115771
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001988 Ailuropoda melanoleuca 92.07 0.00e+00 1083.00
IUUC-Aca-005132 Anolis carolinensis 60.44 0.00e+00 687.00
IUUC-Ame-011102 Astyanax mexicanus 74.64 2.00e-144 505.00
IUUC-Bta-012529 Bos taurus 89.00 0.00e+00 1005.00
IUUC-Bra-016678 Brassica rapa 36.34 3.00e-47 182.00
IUUC-Cja-019016 Callithrix jacchus 88.26 0.00e+00 1026.00
IUUC-Cfa-020714 Canis familiaris 91.59 0.00e+00 1103.00
IUUC-Cpo-021727 Cavia porcellus 88.67 0.00e+00 1037.00
IUUC-Csa-023071 Chlorocebus sabaeus 96.54 0.00e+00 675.00
IUUC-Cin-025797 Ciona intestinalis 50.14 4.00e-95 341.00
IUUC-Csv-026132 Ciona savignyi 51.78 1.00e-98 353.00
IUUC-Dre-027872 Danio rerio 81.52 4.00e-162 563.00
IUUC-Dno-029329 Dasypus novemcinctus 90.78 0.00e+00 1065.00
IUUC-Dor-030574 Dipodomys ordii 91.59 0.00e+00 1059.00
IUUC-Dme-032208 Drosophila melanogaster 46.02 2.00e-82 300.00
IUUC-Ete-032725 Echinops telfairi 80.00 4.00e-174 604.00
IUUC-Eca-033361 Equus caballus 92.07 0.00e+00 1085.00
IUUC-Eeu-035272 Erinaceus europaeus 77.28 0.00e+00 709.00
IUUC-Fca-036497 Felis catus 92.39 0.00e+00 1090.00
IUUC-Fal-036766 Ficedula albicollis 62.66 0.00e+00 681.00
IUUC-Gmo-039129 Gadus morhua 61.11 7.00e-123 433.00
IUUC-Gga-040889 Gallus gallus 82.84 3.00e-146 511.00
IUUC-Gac-042475 Gasterosteus aculeatus 68.97 2.00e-135 475.00
IUUC-Ggo-044814 Gorilla gorilla 90.80 2.00e-174 605.00
IUUC-Hsa-045937 Homo sapiens 89.32 0.00e+00 1018.00
IUUC-Itr-048171 Ictidomys tridecemlineatus 93.37 0.00e+00 1125.00
IUUC-Lch-050527 Latimeria chalumnae 60.03 0.00e+00 631.00
IUUC-Loc-052697 Lepisosteus oculatus 78.29 3.00e-160 558.00
IUUC-Laf-054167 Loxodonta africana 84.70 0.00e+00 996.00
IUUC-Mcc-055584 Macaca mulatta 89.81 0.00e+00 1057.00
IUUC-Meu-056542 Macropus eugenii 85.46 0.00e+00 950.00
IUUC-Mga-060020 Meleagris gallopavo 59.46 0.00e+00 635.00
IUUC-Mmr-060989 Microcebus murinus 91.26 0.00e+00 1073.00
IUUC-Mdo-062761 Monodelphis domestica 84.17 0.00e+00 942.00
IUUC-Mmu-063710 Mus musculus 97.42 0.00e+00 1148.00
IUUC-Mpu-066573 Mustela putorius furo 91.91 0.00e+00 1085.00
IUUC-Nle-070013 Nomascus leucogenys 89.30 0.00e+00 992.00
IUUC-Opr-070907 Ochotona princeps 89.18 0.00e+00 1012.00
IUUC-Ont-071944 Oreochromis niloticus 81.56 3.00e-164 570.00
IUUC-Oan-073105 Ornithorhynchus anatinus 77.88 7.00e-146 509.00
IUUC-Ocu-073941 Oryctolagus cuniculus 90.95 0.00e+00 1062.00
IUUC-Ola-087412 Oryzias latipes 70.05 3.00e-155 541.00
IUUC-Oga-088973 Otolemur garnettii 91.91 0.00e+00 1082.00
IUUC-Oar-089916 Ovis aries 89.64 0.00e+00 1051.00
IUUC-Ptr-090998 Pan troglodytes 89.64 0.00e+00 1025.00
IUUC-Pan-092686 Papio anubis 89.97 0.00e+00 1058.00
IUUC-Psi-093284 Pelodiscus sinensis 69.81 9.00e-122 429.00
IUUC-Pma-094462 Petromyzon marinus 64.71 2.00e-74 271.00
IUUC-Pno-094986 Phaeosphaeria nodorum 32.11 5.00e-39 156.00
IUUC-Pfo-097352 Poecilia formosa 78.93 5.00e-168 584.00
IUUC-Pab-098688 Pongo abelii 83.33 0.00e+00 915.00
IUUC-Pca-100205 Procavia capensis 92.22 0.00e+00 637.00
IUUC-Pva-103188 Pteropus vampyrus 91.42 0.00e+00 1045.00
IUUC-Sha-107237 Sarcophilus harrisii 84.98 0.00e+00 944.00
IUUC-Sar-113103 Sorex araneus 90.20 2.00e-179 621.00
IUUC-Ssc-115955 Sus scrofa 91.91 0.00e+00 1069.00
IUUC-Tgu-116894 Taeniopygia guttata 68.32 0.00e+00 627.00
IUUC-Tru-117703 Takifugu rubripes 66.08 2.00e-134 471.00
IUUC-Tsy-118879 Tarsius syrichta 95.07 0.00e+00 828.00
IUUC-Tni-119866 Tetraodon nigroviridis 75.15 3.00e-153 534.00
IUUC-Tbe-127367 Tupaia belangeri 82.80 0.00e+00 670.00
IUUC-Ttr-128773 Tursiops truncatus 88.35 0.00e+00 1052.00
IUUC-Vpa-130402 Vicugna pacos 81.24 0.00e+00 782.00
IUUC-Xtr-132658 Xenopus tropicalis 57.74 0.00e+00 636.00
Created Date 25-Jun-2017

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