iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cgl-026534

Ensembl Protein ID

ELA31838

UniProt Accession

L2G1F4; L2G1F4_COLGN

Genbank Protein ID

ELA31838.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

KB020732

Gene Name

PAN2; CGGC5_8011

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CGGC5_8011	ELA31838	ELA31838

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-12	47.5	495	815

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 5    NlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaee.fsgyeqqDaq.Eflaflldql 103
            + +  Y NS+LQ+L+++p lr+  l++   ++ e      +++ll+++  lf  l+k + +  + +++lk+l++  +    g  ++D +   l+++l++l
   Q: 495  IHIANSYANSLLQVLHFTPLLRNIALQHAATACVE------DTCLLCEMGFLFDMLQKAEGSICQATNMLKTLSHHPQAgPLGLLEEDPNgSSLTVMLQGL 589
           556677*********************66666654......57*******************************888775458889998725799****** PP
   S: 104  eeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcLesftke 197
            + l++        +            + k  + ++ l+++++  + +s i+c +c+++++r  + +  +l  p+++++  +       +++++L+s +++
   Q: 590  VRFLTE--------K---------IVVDFKSIQPGSGLMDQMLSTSATSFIRCMNCRSEYTRPGSGFFQELMYPQQSKSMVRnqkapkvTFSQILKSSVER 673
           ****22........2.........1234689999**************************99877666666666555554445688888************ PP
   S: 198  eelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp.fctspeekqke.........kkkYeLiavvvHsG 288
           e+     k +c++c+++q+   + +++++P v++++    s ++++  ++  +   e+   +d  + fc +  e+  +          + Y+L+++ v   
   Q: 674  ETTS---KGWCSRCQRYQNIAARKTIHSIPAVFVINTLINSPEHRRFWSTPGFLPEEIGVIVDHGQfFCYE-GEDL-KlhlqrgihnITVYSLVGMAVNID 769
           ***9...59**************************986654444444444444444444444444523333.2222.12344444449*****98876654 PP
   S: 289  ..slssGHYvayvkn........ekgkWllfdDskVtevkeeevle 324
               ++ H va+v+         ++ +W lf+D  V++v  ee l 
   Q: 770  pgAGQKPHLVAMVNVahaqpqvpQTSQWHLFNDFLVRPVATEEALA 815
           4277889*******9777777777777************9988776 PP

Organism

Colletotrichum gloeosporioides

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MDGDWDESAI QVARIPFPPP GVHAMATPVT TMAFDTAQEL LWTGNEYGRV TSFYGSELQR 60
YTSFKAHTTT DGPVRQILVN DKGVVVLGSR DIHMASRKGP PIWHIRHDDM KDLRCMSFTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGGAG ATTGGGACGA GGTAAGTAGC AATCCGGGCC CCTCCTCGCC TGTGGTGTTG 60
CGGCTCGCGT TCCCCTCCAT ACCTACCTCC GCGCGTCGCG GCTGTATTGC ACCTTTTACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	32.43	2.00e-158	551.00
IUUC-Apl-003500	Anas platyrhynchos	29.77	3.00e-86	311.00
IUUC-Aca-004930	Anolis carolinensis	30.07	5.00e-90	324.00
IUUC-Acl-008214	Aspergillus clavatus	51.19	0.00e+00	1156.00
IUUC-Afu-009112	Aspergillus fumigatus	50.82	0.00e+00	1127.00
IUUC-Ang-009531	Aspergillus niger	49.45	0.00e+00	1102.00
IUUC-Ame-011259	Astyanax mexicanus	29.01	2.00e-86	312.00
IUUC-Bta-012371	Bos taurus	32.34	3.00e-158	551.00
IUUC-Bci-013684	Botrytis cinerea	55.19	0.00e+00	1281.00
IUUC-Cja-019297	Callithrix jacchus	31.67	5.00e-155	540.00
IUUC-Cfa-020489	Canis familiaris	32.34	1.00e-156	545.00
IUUC-Cpo-022392	Cavia porcellus	32.44	5.00e-160	556.00
IUUC-Csa-023220	Chlorocebus sabaeus	29.83	1.00e-85	310.00
IUUC-Csv-025841	Ciona savignyi	42.53	5.00e-60	224.00
IUUC-Cne-026932	Cryptococcus neoformans	33.99	9.00e-167	579.00
IUUC-Dre-028482	Danio rerio	28.28	1.00e-81	296.00
IUUC-Dno-029398	Dasypus novemcinctus	29.69	6.00e-85	307.00
IUUC-Dor-030307	Dipodomys ordii	32.62	1.00e-98	353.00
IUUC-Dme-032111	Drosophila melanogaster	28.19	5.00e-77	281.00
IUUC-Eca-033985	Equus caballus	32.34	2.00e-157	548.00
IUUC-Eeu-034928	Erinaceus europaeus	28.95	2.00e-36	146.00
IUUC-Fca-035587	Felis catus	32.26	1.00e-160	559.00
IUUC-Fal-037587	Ficedula albicollis	32.50	3.00e-161	561.00
IUUC-Fso-038133	Fusarium solani	67.12	0.00e+00	1500.00
IUUC-Gmo-039076	Gadus morhua	28.08	1.00e-80	293.00
IUUC-Ggr-039957	Gaeumannomyces graminis	59.62	0.00e+00	1397.00
IUUC-Gga-040948	Gallus gallus	32.42	2.00e-158	551.00
IUUC-Gac-042396	Gasterosteus aculeatus	28.94	8.00e-86	310.00
IUUC-Ggo-045412	Gorilla gorilla	32.52	9.00e-158	549.00
IUUC-Hsa-046076	Homo sapiens	32.52	1.00e-157	548.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	30.72	5.00e-136	477.00
IUUC-Kpa-049178	Komagataella pastoris	32.56	6.00e-171	593.00
IUUC-Lch-050279	Latimeria chalumnae	29.75	1.00e-129	456.00
IUUC-Loc-052872	Lepisosteus oculatus	28.42	2.00e-82	299.00
IUUC-Lma-052986	Leptosphaeria maculans	53.39	0.00e+00	1195.00
IUUC-Laf-054181	Loxodonta africana	29.13	1.00e-79	290.00
IUUC-Mcc-054812	Macaca mulatta	32.17	1.00e-155	542.00
IUUC-Meu-056325	Macropus eugenii	32.46	4.00e-155	540.00
IUUC-Mor-057246	Magnaporthe oryzae	50.53	0.00e+00	1114.00
IUUC-Mpo-057464	Magnaporthe poae	59.58	0.00e+00	1399.00
IUUC-Mla-058911	Melampsora laricipopulina	40.78	9.00e-127	446.00
IUUC-Mga-059335	Meleagris gallopavo	30.04	3.00e-89	322.00
IUUC-Mvi-060461	Microbotryum violaceum	35.95	0.00e+00	632.00
IUUC-Mmr-060636	Microcebus murinus	32.26	6.00e-156	543.00
IUUC-Mmu-063503	Mus musculus	32.40	1.00e-158	552.00
IUUC-Mpu-066670	Mustela putorius furo	32.34	4.00e-158	550.00
IUUC-Mlu-068119	Myotis lucifugus	32.09	2.00e-162	565.00
IUUC-Nfi-068398	Neosartorya fischeri	51.32	0.00e+00	1157.00
IUUC-Ncr-068927	Neurospora crassa	53.62	0.00e+00	1156.00
IUUC-Nle-069651	Nomascus leucogenys	31.47	2.00e-148	518.00
IUUC-Opr-070614	Ochotona princeps	31.82	5.00e-154	536.00
IUUC-Ont-072433	Oreochromis niloticus	29.22	3.00e-88	318.00
IUUC-Oan-073283	Ornithorhynchus anatinus	41.40	6.00e-66	244.00
IUUC-Ocu-074401	Oryctolagus cuniculus	29.87	6.00e-85	307.00
IUUC-Ola-087522	Oryzias latipes	27.72	1.00e-82	299.00
IUUC-Oga-088226	Otolemur garnettii	29.31	2.00e-86	312.00
IUUC-Oar-089241	Ovis aries	32.43	3.00e-161	561.00
IUUC-Pan-092297	Papio anubis	32.19	2.00e-143	501.00
IUUC-Psi-094043	Pelodiscus sinensis	29.26	2.00e-85	308.00
IUUC-Pma-094394	Petromyzon marinus	31.55	1.00e-144	505.00
IUUC-Pno-095053	Phaeosphaeria nodorum	53.88	0.00e+00	1085.00
IUUC-Ppa-095188	Physcomitrella patens	26.25	2.00e-64	239.00
IUUC-Pfo-097517	Poecilia formosa	31.54	1.00e-159	555.00
IUUC-Pca-100471	Procavia capensis	32.04	4.00e-156	543.00
IUUC-Pva-102805	Pteropus vampyrus	30.51	4.00e-122	431.00
IUUC-Pte-104021	Pyrenophora teres	53.56	0.00e+00	1197.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	53.34	0.00e+00	1191.00
IUUC-Rno-105471	Rattus norvegicus	32.54	3.00e-160	558.00
IUUC-Sce-106235	Saccharomyces cerevisiae	29.15	3.00e-121	427.00
IUUC-Sha-106883	Sarcophilus harrisii	29.67	2.00e-77	282.00
IUUC-Spo-108169	Schizosaccharomyces pombe	37.52	0.00e+00	704.00
IUUC-Sar-113323	Sorex araneus	33.07	6.00e-127	447.00
IUUC-Sre-115075	Sporisorium reilianum	43.90	4.00e-66	245.00
IUUC-Ssc-116363	Sus scrofa	29.87	2.00e-85	309.00
IUUC-Tru-118427	Takifugu rubripes	29.04	1.00e-88	320.00
IUUC-Tni-120218	Tetraodon nigroviridis	28.49	2.00e-87	316.00
IUUC-Tre-122177	Trichoderma reesei	68.19	0.00e+00	1643.00
IUUC-Tme-127176	Tuber melanosporum	47.05	0.00e+00	931.00
IUUC-Tbe-127641	Tupaia belangeri	26.65	3.00e-34	139.00
IUUC-Ttr-128888	Tursiops truncatus	33.79	3.00e-107	381.00
IUUC-Uma-129361	Ustilago maydis	43.57	2.00e-64	239.00
IUUC-Xtr-132811	Xenopus tropicalis	28.49	6.00e-80	291.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence