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Tag Content
UUCD2 ID IUUC-Ssc-116363
UUCD1 version UUC-SuS-00892
Ensembl Protein ID ENSSSCP00000000418.2
UniProt Accession F1SLY8; F1SLY8_PIG
Genbank Protein ID ENSSSCP00000000418
Protein Name PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2
Genbank Nucleotide ID CU498845
Gene Name PAN2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSSCG00000000393.2 ENSSSCT00000000424.2 ENSSSCP00000000418.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 4.90e-21 75.5 525 914
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+ + +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 525  NAYCNCMIQVLYFLEPVRCVIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 604
           56*********************...55654......57*************9****************99999866766666666666 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql+++l+           e +  ++ + a  +  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 605  gkGNLARLIQRWNRFILTQLHQDLQ-----------ELEVPQAYRGAGGSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLF 681
           6566666667777788888888882...........233334556678899*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+ p++++ k+ ++ ++L+     e+ +   + +c++c+k+q + ++  +++lP++L+++    s +e+   r  ++ +v f+  + +
   Q: 682  TLSYPEDKTGKNCDFAQVLKRSICLEQNT---QAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSLKEADFWR--MQAEVAFK--MAI 763
           *******************9888766665...69*****************************99888887765..77888887..445 PP
   S: 262  spfcts..............................peekqke.............................................. 274
           +++  +                              +     +                                              
   Q: 764  KKHGGEisknkefaladwnelgspegmrmcpsieelK-----Nvwlpfsirmkmtknkgldvcnwtdgdeilaawvppsqwgparaeee 847
           5555442233444555555555555555555555550.....05555555555555555555666666666666666666666666666 PP
   S: 275  ..kkkYeLiavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
              + Y+L+a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 848  hgVYVYDLMATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDM 914
           669*************9*************999988877777888************9999888654 PP
   
Organism Sus scrofa
Functional Description
(View)

Functional Description


     Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
 Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Protein Sequence
(Fasta)
MNFESLDPGL AEYTPSMHSA LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGSDDIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ssc-116363|DUB,USP|Sus scrofa
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAACTTCG AGAGTCTGGA CCCTGGCCTG GCAGAGTATA CCCCGTCCAT GCATTCCGCC 60
CTGGATCCTG TCCTGGATGC CCACCTGAAC CCAAGTCTGC TGCAGAATGT GGAGCTAGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ssc-116363|DUB,USP|Sus scrofa
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome
Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50235--USP_3
Pfam

PF00929--RNase_T
PF13423--UCH_1
SMART

SM00479--EXOIII
Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001273 Ailuropoda melanoleuca 97.52 0.00e+00 2339.00
IUUC-Apl-003500 Anas platyrhynchos 84.45 0.00e+00 1868.00
IUUC-Aca-004930 Anolis carolinensis 84.01 0.00e+00 2023.00
IUUC-Acl-008214 Aspergillus clavatus 31.15 5.00e-156 545.00
IUUC-Afu-009112 Aspergillus fumigatus 31.25 2.00e-140 493.00
IUUC-Ang-009531 Aspergillus niger 30.91 1.00e-148 520.00
IUUC-Ame-011259 Astyanax mexicanus 75.02 0.00e+00 1820.00
IUUC-Bta-012371 Bos taurus 97.84 0.00e+00 2343.00
IUUC-Bci-013684 Botrytis cinerea 42.72 1.00e-71 265.00
IUUC-Cja-019297 Callithrix jacchus 93.90 0.00e+00 2259.00
IUUC-Cfa-020489 Canis familiaris 97.26 0.00e+00 2324.00
IUUC-Cpo-022392 Cavia porcellus 95.45 0.00e+00 2310.00
IUUC-Csa-023220 Chlorocebus sabaeus 96.61 0.00e+00 2324.00
IUUC-Csv-025841 Ciona savignyi 45.78 0.00e+00 900.00
IUUC-Cgl-026534 Colletotrichum gloeosporioides 30.12 1.00e-88 321.00
IUUC-Cne-026932 Cryptococcus neoformans 42.94 4.00e-73 269.00
IUUC-Dre-028482 Danio rerio 73.36 0.00e+00 1770.00
IUUC-Dno-029398 Dasypus novemcinctus 96.27 0.00e+00 2300.00
IUUC-Dor-030307 Dipodomys ordii 88.98 0.00e+00 1293.00
IUUC-Dme-032111 Drosophila melanogaster 41.29 0.00e+00 882.00
IUUC-Eca-033985 Equus caballus 98.09 0.00e+00 2348.00
IUUC-Eeu-034928 Erinaceus europaeus 84.41 0.00e+00 775.00
IUUC-Fca-035587 Felis catus 97.44 0.00e+00 2340.00
IUUC-Fal-037587 Ficedula albicollis 83.80 0.00e+00 1973.00
IUUC-Fso-038133 Fusarium solani 42.29 2.00e-77 283.00
IUUC-Gmo-039076 Gadus morhua 73.00 0.00e+00 1733.00
IUUC-Ggr-039957 Gaeumannomyces graminis 31.76 1.00e-137 483.00
IUUC-Gga-040948 Gallus gallus 84.78 0.00e+00 2047.00
IUUC-Gac-042396 Gasterosteus aculeatus 73.59 0.00e+00 1783.00
IUUC-Ggo-045412 Gorilla gorilla 96.69 0.00e+00 2321.00
IUUC-Hsa-046076 Homo sapiens 96.69 0.00e+00 2327.00
IUUC-Itr-048143 Ictidomys tridecemlineatus 90.48 0.00e+00 2110.00
IUUC-Kpa-049178 Komagataella pastoris 40.48 7.00e-67 248.00
IUUC-Lch-050279 Latimeria chalumnae 72.24 0.00e+00 1704.00
IUUC-Loc-052872 Lepisosteus oculatus 75.88 0.00e+00 1816.00
IUUC-Lma-052986 Leptosphaeria maculans 31.27 1.00e-92 335.00
IUUC-Laf-054181 Loxodonta africana 95.68 0.00e+00 2308.00
IUUC-Mcc-054812 Macaca mulatta 97.01 0.00e+00 2326.00
IUUC-Meu-056325 Macropus eugenii 91.57 0.00e+00 2193.00
IUUC-Mor-057246 Magnaporthe oryzae 27.24 4.00e-65 243.00
IUUC-Mpo-057464 Magnaporthe poae 31.67 4.00e-138 485.00
IUUC-Mla-058911 Melampsora laricipopulina 40.48 2.00e-69 258.00
IUUC-Mga-059335 Meleagris gallopavo 85.36 0.00e+00 2003.00
IUUC-Mvi-060461 Microbotryum violaceum 34.11 5.00e-145 508.00
IUUC-Mmr-060636 Microcebus murinus 97.10 0.00e+00 2324.00
IUUC-Mmu-063503 Mus musculus 95.44 0.00e+00 2279.00
IUUC-Mpu-066670 Mustela putorius furo 98.09 0.00e+00 2348.00
IUUC-Mlu-068119 Myotis lucifugus 96.60 0.00e+00 2353.00
IUUC-Nfi-068398 Neosartorya fischeri 31.91 2.00e-155 543.00
IUUC-Ncr-068927 Neurospora crassa 29.55 6.00e-121 429.00
IUUC-Nle-069651 Nomascus leucogenys 92.73 0.00e+00 2222.00
IUUC-Opr-070614 Ochotona princeps 95.47 0.00e+00 2266.00
IUUC-Ont-072433 Oreochromis niloticus 74.67 0.00e+00 1840.00
IUUC-Oan-073283 Ornithorhynchus anatinus 73.72 0.00e+00 1422.00
IUUC-Ocu-074401 Oryctolagus cuniculus 97.10 0.00e+00 2341.00
IUUC-Ola-087522 Oryzias latipes 73.82 0.00e+00 1780.00
IUUC-Oga-088226 Otolemur garnettii 97.10 0.00e+00 2345.00
IUUC-Oar-089241 Ovis aries 97.60 0.00e+00 2365.00
IUUC-Pan-092297 Papio anubis 97.09 0.00e+00 2084.00
IUUC-Psi-094043 Pelodiscus sinensis 81.59 0.00e+00 1911.00
IUUC-Pma-094394 Petromyzon marinus 68.55 0.00e+00 1550.00
IUUC-Pno-095053 Phaeosphaeria nodorum 31.13 2.00e-82 300.00
IUUC-Ppa-095188 Physcomitrella patens 32.57 1.00e-157 550.00
IUUC-Pfo-097517 Poecilia formosa 74.55 0.00e+00 1835.00
IUUC-Pca-100471 Procavia capensis 96.23 0.00e+00 2169.00
IUUC-Pva-102805 Pteropus vampyrus 93.15 0.00e+00 1838.00
IUUC-Pte-104021 Pyrenophora teres 30.79 1.00e-94 341.00
IUUC-Pyt-104682 Pyrenophora triticirepentis 30.50 2.00e-93 337.00
IUUC-Rno-105471 Rattus norvegicus 94.77 0.00e+00 2268.00
IUUC-Sce-106235 Saccharomyces cerevisiae 38.05 1.00e-60 228.00
IUUC-Sha-106883 Sarcophilus harrisii 91.67 0.00e+00 2047.00
IUUC-Spo-108169 Schizosaccharomyces pombe 44.22 3.00e-74 273.00
IUUC-Sar-113323 Sorex araneus 95.33 0.00e+00 1717.00
IUUC-Sre-115075 Sporisorium reilianum 37.90 1.00e-60 228.00
IUUC-Tru-118427 Takifugu rubripes 74.20 0.00e+00 1850.00
IUUC-Tni-120218 Tetraodon nigroviridis 74.35 0.00e+00 1852.00
IUUC-Tre-122177 Trichoderma reesei 29.05 1.00e-77 284.00
IUUC-Tme-127176 Tuber melanosporum 32.16 3.00e-138 486.00
IUUC-Tbe-127641 Tupaia belangeri 87.83 0.00e+00 801.00
IUUC-Ttr-128888 Tursiops truncatus 96.70 0.00e+00 1478.00
IUUC-Uma-129361 Ustilago maydis 38.42 3.00e-63 237.00
IUUC-Xtr-132811 Xenopus tropicalis 79.20 0.00e+00 1896.00
Created Date 25-Jun-2017

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