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Tag Content
iUUCD ID IUUC-Lma-053170
Ensembl Protein ID CBY00366
UniProt Accession E5A9M5; E5A9M5_LEPMJ
Genbank Protein ID CBY00366.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID FP929138
Gene Name PAC1; LIS1; LEMA_P014960.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
LEMA_P014960.1 CBY00366 CBY00366
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.70e-47 156.0 202 249
UBD/Beta-Prp 2.30e-66 223.3 114 409
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.........sd.tllvsGsdDgtikvWDlrtgvllks 38
    gH sv++++f s+ +llvs+s+D+t+++WD++tg ++k+
   Q: 202 GHDHSVSAIRFipsgaagspSSgNLLVSASRDKTLRIWDVTTGYCVKT 249
    8******************8557********************99875 PP
   


   UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsp 104
    ++h ++itcv+f+p s la+gs+d tik+wd++ g l r+++gh+++v +v+f + +l+++s+D tik+wd+s +k ++tl gh++sv +++f p
   Q: 114 QSHRQPITCVAFHPVFSSLASGSEDTTIKIWDWELGELERTVKGHTKGVLDVDFGGPRGgtLLASCSSDLTIKLWDPSdEYKNIRTLPGHDHSVSAIRFIP 214
    45677*************************************************8544446**************887699******************99 PP
   S: 105 ........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls.......... 187
    sg+ lvs+s+d+t+r+wd+ tg+c++ t +gh ++v+ v+ + dg+ lvs+++D+t rlWd ++g+ t+ g h++ +++++
   Q: 215 sgaagspsSGNLLVSASRDKTLRIWDVTTGYCVK-TIRGHADWVRDVAPSFDGRWLVSAGNDQTARLWDASSGEAKCTFLG-HEHVIECVTiappvsyanl 313
    9999999888************************.*********************************************9.*********8888777777 PP
   S: 188 ...........fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlqlhnssvisvav 272
    ++s+ +++++gs+d+++k+wd +g+ ++tl gh+++v+ + f+p +++l+s+s+D++ir+Wdl + g ++kt+q + +++s+
   Q: 314 aslaglkkpppLSSSAEFIATGSRDKSIKIWDG-RGTLIKTLMGHDNWVRALVFHPGGKYLLSASDDKTIRCWDLtQEGRCVKTVQDAHGHFVSCMR 409
    6666666666666666****************9.7889************************************83579**********88777755 PP
   

Organism Leptosphaeria maculans
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MSSSLLLTDR QAEELHKSII AYLGVINAPR AAEAFREEAN IPASFDEATR KKYEGILEKK 60
WTSVVRLQKK ILDLEQRNAS LQSELDSNTP TSLLRKNQDP TAWLPRAPAR HTLQSHRQPI 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Lma-053170|E3,WD_repeat;UBD,Beta-Prp|Leptosphaeria maculans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCTCGT CGTTGCTGCT GACAGACCGG CAAGCCGAAG AGCTGTGAGC TTTTGCCAGC 60
AGCCCGACAT GTGAAAAAAA AAGAAGGACG CTAACGGGCA GGGCAGACAC AAGTCGATAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Lma-053170|E3,WD_repeat;UBD,Beta-Prp|Leptosphaeria maculans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 46.70 5.00e-104 369.00
IUUC-Apl-004024 Anas platyrhynchos 46.67 2.00e-107 380.00
IUUC-Aca-004564 Anolis carolinensis 46.43 2.00e-105 374.00
IUUC-Ago-007862 Ashbya gossypii 29.42 1.00e-40 158.00
IUUC-Acl-008360 Aspergillus clavatus 74.03 0.00e+00 679.00
IUUC-Afl-008502 Aspergillus flavus 63.17 3.00e-163 566.00
IUUC-Afu-008848 Aspergillus fumigatus 75.37 0.00e+00 721.00
IUUC-Ani-009173 Aspergillus nidulans 62.61 8.00e-172 594.00
IUUC-Ang-009873 Aspergillus niger 60.75 3.00e-164 569.00
IUUC-Aor-009973 Aspergillus oryzae 60.74 3.00e-157 546.00
IUUC-Ate-010523 Aspergillus terreus 61.22 8.00e-166 574.00
IUUC-Ame-010969 Astyanax mexicanus 46.19 5.00e-106 375.00
IUUC-Bgr-011972 Blumeria graminis 75.49 0.00e+00 726.00
IUUC-Bta-013106 Bos taurus 46.67 1.00e-107 381.00
IUUC-Bci-013615 Botrytis cinerea 78.28 0.00e+00 731.00
IUUC-Cel-018459 Caenorhabditis elegans 44.17 2.00e-95 340.00
IUUC-Cja-018755 Callithrix jacchus 45.95 5.00e-105 372.00
IUUC-Cfa-020749 Canis familiaris 46.67 1.00e-107 381.00
IUUC-Cpo-022371 Cavia porcellus 46.67 1.00e-107 381.00
IUUC-Csa-023524 Chlorocebus sabaeus 47.03 5.00e-90 322.00
IUUC-Cho-024764 Choloepus hoffmanni 43.97 5.00e-89 319.00
IUUC-Cin-025753 Ciona intestinalis 47.52 6.00e-101 358.00
IUUC-Csv-025817 Ciona savignyi 46.53 2.00e-103 367.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 75.54 0.00e+00 689.00
IUUC-Cne-027087 Cryptococcus neoformans 53.35 1.00e-119 421.00
IUUC-Dre-027554 Danio rerio 45.71 5.00e-104 369.00
IUUC-Dno-029050 Dasypus novemcinctus 46.67 1.00e-107 381.00
IUUC-Dor-030222 Dipodomys ordii 43.48 3.00e-98 350.00
IUUC-Dse-031164 Dothistroma septosporum 70.39 0.00e+00 671.00
IUUC-Dme-031745 Drosophila melanogaster 46.42 6.00e-98 349.00
IUUC-Ete-032508 Echinops telfairi 48.23 1.00e-72 265.00
IUUC-Eca-034288 Equus caballus 46.21 6.00e-103 365.00
IUUC-Eeu-034984 Erinaceus europaeus 43.24 4.00e-97 346.00
IUUC-Fca-036498 Felis catus 46.67 1.00e-107 381.00
IUUC-Fal-036920 Ficedula albicollis 46.67 2.00e-107 380.00
IUUC-Fox-037996 Fusarium oxysporum 68.60 0.00e+00 664.00
IUUC-Fso-038160 Fusarium solani 66.45 0.00e+00 629.00
IUUC-Gmo-038983 Gadus morhua 45.95 7.00e-106 375.00
IUUC-Ggr-040051 Gaeumannomyces graminis 67.60 0.00e+00 644.00
IUUC-Gga-040623 Gallus gallus 46.67 2.00e-107 380.00
IUUC-Gac-041613 Gasterosteus aculeatus 45.78 6.00e-105 372.00
IUUC-Ggo-045410 Gorilla gorilla 45.75 3.00e-87 313.00
IUUC-Hsa-046358 Homo sapiens 46.67 2.00e-107 380.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 46.67 1.00e-107 381.00
IUUC-Kpa-049351 Komagataella pastoris 30.32 1.00e-46 179.00
IUUC-Lch-049936 Latimeria chalumnae 46.43 1.00e-106 378.00
IUUC-Loc-052476 Lepisosteus oculatus 46.45 5.00e-103 365.00
IUUC-Laf-053713 Loxodonta africana 46.84 6.00e-105 372.00
IUUC-Mcc-054628 Macaca mulatta 46.67 2.00e-107 380.00
IUUC-Meu-055927 Macropus eugenii 40.43 5.00e-53 199.00
IUUC-Mor-056962 Magnaporthe oryzae 67.90 0.00e+00 653.00
IUUC-Mpo-057583 Magnaporthe poae 66.95 2.00e-179 620.00
IUUC-Mla-058819 Melampsora laricipopulina 48.71 8.00e-120 422.00
IUUC-Mga-059945 Meleagris gallopavo 46.43 5.00e-107 379.00
IUUC-Mvi-060403 Microbotryum violaceum 51.19 6.00e-132 462.00
IUUC-Mmr-061289 Microcebus murinus 46.70 6.00e-104 369.00
IUUC-Mdo-061912 Monodelphis domestica 46.43 1.00e-106 378.00
IUUC-Mmu-063253 Mus musculus 46.67 1.00e-107 381.00
IUUC-Mpu-066638 Mustela putorius furo 46.67 1.00e-107 381.00
IUUC-Mlu-067267 Myotis lucifugus 46.02 4.00e-104 369.00
IUUC-Nfi-068571 Neosartorya fischeri 69.74 0.00e+00 661.00
IUUC-Ncr-068895 Neurospora crassa 73.06 0.00e+00 673.00
IUUC-Nle-069087 Nomascus leucogenys 45.38 9.00e-88 315.00
IUUC-Opr-070579 Ochotona princeps 46.67 1.00e-107 381.00
IUUC-Ont-072432 Oreochromis niloticus 46.19 3.00e-106 376.00
IUUC-Oan-073072 Ornithorhynchus anatinus 46.67 1.00e-107 381.00
IUUC-Ocu-074180 Oryctolagus cuniculus 46.67 1.00e-107 381.00
IUUC-Ola-086815 Oryzias latipes 46.19 1.00e-105 374.00
IUUC-Oga-088219 Otolemur garnettii 46.06 8.00e-105 372.00
IUUC-Oar-090394 Ovis aries 46.67 1.00e-107 381.00
IUUC-Ptr-091517 Pan troglodytes 46.67 1.00e-107 381.00
IUUC-Pan-092421 Papio anubis 46.67 2.00e-107 380.00
IUUC-Psi-093370 Pelodiscus sinensis 46.67 3.00e-107 379.00
IUUC-Pma-094319 Petromyzon marinus 45.14 2.00e-86 310.00
IUUC-Pno-094815 Phaeosphaeria nodorum 91.54 0.00e+00 840.00
IUUC-Pfo-097089 Poecilia formosa 46.43 4.00e-106 376.00
IUUC-Pab-098421 Pongo abelii 46.67 1.00e-107 381.00
IUUC-Pca-100120 Procavia capensis 38.86 1.00e-62 231.00
IUUC-Pva-102960 Pteropus vampyrus 46.43 3.00e-106 376.00
IUUC-Pgr-103538 Puccinia graminis 50.43 7.00e-123 432.00
IUUC-Ptt-103990 Puccinia triticina 40.54 2.00e-40 159.00
IUUC-Pte-104261 Pyrenophora teres 92.39 0.00e+00 851.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 91.96 0.00e+00 849.00
IUUC-Rno-105123 Rattus norvegicus 46.67 1.00e-107 381.00
IUUC-Sce-106208 Saccharomyces cerevisiae 28.57 5.00e-39 153.00
IUUC-Sha-107010 Sarcophilus harrisii 46.43 6.00e-107 379.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 38.67 4.00e-70 256.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 77.23 0.00e+00 700.00
IUUC-Sar-113309 Sorex araneus 45.97 2.00e-101 360.00
IUUC-Sre-115003 Sporisorium reilianum 49.25 2.00e-126 443.00
IUUC-Ssc-116148 Sus scrofa 46.67 1.00e-107 381.00
IUUC-Tgu-117299 Taeniopygia guttata 46.67 2.00e-107 380.00
IUUC-Tru-118179 Takifugu rubripes 45.71 2.00e-105 374.00
IUUC-Tsy-119493 Tarsius syrichta 46.43 6.00e-106 375.00
IUUC-Tni-120355 Tetraodon nigroviridis 45.78 2.00e-104 370.00
IUUC-Tre-121977 Trichoderma reesei 61.91 5.00e-166 575.00
IUUC-Tvi-122661 Trichoderma virens 63.09 6.00e-168 582.00
IUUC-Tme-127031 Tuber melanosporum 68.56 0.00e+00 634.00
IUUC-Tbe-127492 Tupaia belangeri 41.33 8.00e-50 189.00
IUUC-Ttr-128929 Tursiops truncatus 46.67 2.00e-107 380.00
IUUC-Uma-129347 Ustilago maydis 50.43 6.00e-126 442.00
IUUC-Vda-129837 Verticillium dahliae 71.92 0.00e+00 655.00
IUUC-Vpa-130532 Vicugna pacos 40.35 1.00e-86 311.00
IUUC-Xtr-131985 Xenopus tropicalis 46.67 2.00e-107 380.00
IUUC-Xma-133314 Xiphophorus maculatus 46.19 1.00e-105 375.00
IUUC-Yli-134403 Yarrowia lipolytica 43.33 5.00e-103 366.00
Created Date 25-Jun-2017

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