iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Sce-106204

UUCD1 version

UUC-SaC-00219

Ensembl Protein ID

YPL151C

UniProt Accession

Q12417; D6W3L8; PRP46_YEAST

Genbank Protein ID

CAA65570.1; CAA97856.1; DAA11284.1

Protein Name

Pre-mRNA-splicing factor PRP46; Complexed with CEF1 protein 1; PRP nineteen-associated complex protein 50; PRP19-associated complex protein 50; Pre-mRNA-processing protein 46

Genbank Nucleotide ID

X96770; Z73507; BK006949

Gene Name

PRP46; CWC1; NTC50; YPL151C; P2594

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YPL151C	YPL151C	YPL151C

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.10e-37	122.8	137	174
UBD/Beta-Prp	5.90e-59	198.1	217	430

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvl 35
           gH ++v+c+a    ++  +++Gs+D t+kvWDl tg+l
   Q: 137  GHLGWVRCVAIdpvDNEWFITGSNDTTMKVWDLATGKL 174
           8***********954499*****************987 PP

UBD/Beta-Prp

   S: 45   lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvv 145
           +r ++gh ++v++v+++p+ ++++t+++D +ik+wd++t+ +v+tl gh+  +  ++  p +  +vs s d t+r+wd+  g+ ++ +l+ h+++v+ +++
   Q: 217  IRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMK-VLTHHKRSVRATAL 316
           7889**********************************************************************************.************** PP
   S: 146  hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlq.........tgecvrtlnghtdnvksvrfspnderl 237
           hp+++ ++s+++D  +r W l+ g+ll+ +++++t+ ++ ls++++   l +g+++g + ++d++         t e+v +l+g  + v++  f++ + rl
   Q: 317  HPKEFSVASACTDD-IRSWGLAEGSLLTNFESEKTGIINTLSINQD-DVLFAGGDNGVLSFYDYKsghkyqslaTREMVGSLEGE-RSVLCSTFDKTGLRL 414
           ************96.999**************9************8.58999*************55555555555556666665.579999********* PP
   S: 238  vsgssDgsiriWdlrsgd 255
           ++g +D+si+iW  ++++
   Q: 415  ITGEADKSIKIW--KQDE 430
           ************..2332 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Involved in pre-mRNA splicing. May also be required for cell cycle progression at G2/M (By similarity).

Protein Sequence
(Fasta)

MDGNDHKVEN LGDVDKFYSR IRWNNQFSYM ATLPPHLQSE MEGQKSLLMR YDTYRKESSS 60
FSGEGKKVTL QHVPTDFSEA SQAVISKKDH DTHASAFVNK IFQPEVAEEL IVNRYEKLLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGGAA ATGATCACAA AGTCGAAAAT TTAGGAGATG TAGACAAATT TTATTCCAGA 60
ATACGCTGGA ATAACCAATT TTCATATATG GCCACTCTGC CGCCCCACCT ACAAAGCGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0005681--C:spliceosomal complex
GO:0000398--P:mRNA splicing, via spliceosome

KEGG

sce:YPL151C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000084	Aegilops tauschii	44.76	2.00e-103	367.00
IUUC-Aml-001605	Ailuropoda melanoleuca	50.45	8.00e-105	372.00
IUUC-Atr-002757	Amborella trichopoda	53.61	2.00e-102	364.00
IUUC-Apl-003198	Anas platyrhynchos	50.15	4.00e-104	369.00
IUUC-Aca-004683	Anolis carolinensis	49.55	1.00e-103	368.00
IUUC-Aly-005775	Arabidopsis lyrata	53.64	8.00e-108	381.00
IUUC-Ath-007460	Arabidopsis thaliana	53.33	3.00e-107	379.00
IUUC-Ago-007884	Ashbya gossypii	58.58	4.00e-157	545.00
IUUC-Acl-008153	Aspergillus clavatus	56.89	1.00e-116	410.00
IUUC-Afl-008384	Aspergillus flavus	52.38	1.00e-119	421.00
IUUC-Afu-009045	Aspergillus fumigatus	56.01	2.00e-115	407.00
IUUC-Ani-009229	Aspergillus nidulans	57.77	7.00e-118	415.00
IUUC-Ang-009812	Aspergillus niger	58.31	2.00e-109	386.00
IUUC-Aor-010059	Aspergillus oryzae	52.38	1.00e-119	421.00
IUUC-Ate-010351	Aspergillus terreus	57.18	5.00e-123	432.00
IUUC-Ame-011613	Astyanax mexicanus	32.84	5.00e-50	189.00
IUUC-Bgr-012042	Blumeria graminis	61.08	5.00e-129	452.00
IUUC-Bta-012406	Bos taurus	50.45	1.00e-104	371.00
IUUC-Bci-013760	Botrytis cinerea	55.16	2.00e-120	423.00
IUUC-Bdi-014776	Brachypodium distachyon	47.42	6.00e-106	375.00
IUUC-Bol-016189	Brassica oleracea	53.33	2.00e-107	380.00
IUUC-Bra-018044	Brassica rapa	53.33	2.00e-107	380.00
IUUC-Cel-018651	Caenorhabditis elegans	51.81	4.00e-105	372.00
IUUC-Cja-019974	Callithrix jacchus	50.15	2.00e-104	370.00
IUUC-Cfa-021085	Canis familiaris	50.45	8.00e-105	372.00
IUUC-Cpo-021458	Cavia porcellus	50.15	2.00e-104	370.00
IUUC-Cre-022880	Chlamydomonas reinhardtii	54.55	3.00e-111	392.00
IUUC-Csa-023883	Chlorocebus sabaeus	50.15	2.00e-104	370.00
IUUC-Cho-024623	Choloepus hoffmanni	49.54	5.00e-101	359.00
IUUC-Cin-025190	Ciona intestinalis	49.85	3.00e-102	363.00
IUUC-Csv-026367	Ciona savignyi	43.39	4.00e-105	373.00
IUUC-Cgl-026499	Colletotrichum gloeosporioides	54.93	5.00e-124	435.00
IUUC-Cne-027069	Cryptococcus neoformans	45.28	6.00e-109	385.00
IUUC-Cme-027233	Cyanidioschyzon merolae	29.82	3.00e-27	114.00
IUUC-Dre-028260	Danio rerio	47.37	1.00e-104	371.00
IUUC-Dno-029112	Dasypus novemcinctus	50.15	2.00e-104	370.00
IUUC-Dor-031118	Dipodomys ordii	50.76	5.00e-105	372.00
IUUC-Dse-031493	Dothistroma septosporum	55.33	4.00e-111	393.00
IUUC-Dme-032138	Drosophila melanogaster	51.23	2.00e-104	370.00
IUUC-Ete-032411	Echinops telfairi	41.43	5.00e-83	299.00
IUUC-Eca-033521	Equus caballus	49.85	4.00e-104	369.00
IUUC-Eeu-035249	Erinaceus europaeus	43.50	3.00e-80	290.00
IUUC-Fca-036358	Felis catus	50.76	4.00e-105	372.00
IUUC-Fal-036933	Ficedula albicollis	50.15	3.00e-104	370.00
IUUC-Fox-037713	Fusarium oxysporum	48.84	6.00e-124	435.00
IUUC-Fso-038380	Fusarium solani	57.88	2.00e-120	424.00
IUUC-Gmo-039133	Gadus morhua	50.15	5.00e-103	365.00
IUUC-Ggr-039915	Gaeumannomyces graminis	56.59	4.00e-113	399.00
IUUC-Gga-041176	Gallus gallus	50.76	2.00e-104	370.00
IUUC-Gac-042344	Gasterosteus aculeatus	51.06	7.00e-105	372.00
IUUC-Gma-043328	Glycine max	52.73	6.00e-105	372.00
IUUC-Ggo-044478	Gorilla gorilla	50.15	2.00e-104	370.00
IUUC-Hsa-046037	Homo sapiens	50.15	2.00e-104	370.00
IUUC-Hvu-047349	Hordeum vulgare	55.08	2.00e-107	380.00
IUUC-Itr-048390	Ictidomys tridecemlineatus	50.15	2.00e-104	370.00
IUUC-Kpa-049343	Komagataella pastoris	60.62	1.00e-124	437.00
IUUC-Lch-049830	Latimeria chalumnae	50.45	8.00e-106	375.00
IUUC-Lpe-051442	Leersia perrieri	54.24	2.00e-107	380.00
IUUC-Loc-051794	Lepisosteus oculatus	50.48	6.00e-100	355.00
IUUC-Lma-053137	Leptosphaeria maculans	54.73	2.00e-115	407.00
IUUC-Laf-053471	Loxodonta africana	50.15	1.00e-104	371.00
IUUC-Mcc-055627	Macaca mulatta	50.15	2.00e-104	370.00
IUUC-Meu-056148	Macropus eugenii	48.94	7.00e-102	362.00
IUUC-Mor-056960	Magnaporthe oryzae	55.01	5.00e-120	422.00
IUUC-Mtr-057816	Medicago truncatula	51.52	2.00e-103	367.00
IUUC-Mla-059031	Melampsora laricipopulina	51.69	1.00e-101	360.00
IUUC-Mga-059337	Meleagris gallopavo	50.76	3.00e-104	370.00
IUUC-Mvi-060217	Microbotryum violaceum	53.21	1.00e-106	377.00
IUUC-Mmr-061018	Microcebus murinus	50.15	2.00e-104	370.00
IUUC-Mdo-062863	Monodelphis domestica	49.54	9.00e-103	365.00
IUUC-Mmu-063988	Mus musculus	50.45	6.00e-104	369.00
IUUC-Mac-064459	Musa acuminata	52.04	2.00e-100	357.00
IUUC-Mpu-066559	Mustela putorius furo	50.45	8.00e-105	372.00
IUUC-Mlu-067361	Myotis lucifugus	50.15	2.00e-104	370.00
IUUC-Nfi-068492	Neosartorya fischeri	56.30	9.00e-116	408.00
IUUC-Ncr-068808	Neurospora crassa	46.95	2.00e-119	420.00
IUUC-Nle-069875	Nomascus leucogenys	50.15	2.00e-104	370.00
IUUC-Opr-070462	Ochotona princeps	48.69	3.00e-80	290.00
IUUC-Ont-071365	Oreochromis niloticus	50.15	1.00e-103	367.00
IUUC-Oan-072708	Ornithorhynchus anatinus	49.85	2.00e-104	370.00
IUUC-Ocu-074594	Oryctolagus cuniculus	47.78	1.00e-104	371.00
IUUC-Oba-075570	Oryza barthii	53.94	8.00e-107	378.00
IUUC-Obr-076366	Oryza brachyantha	54.62	6.00e-80	288.00
IUUC-Ogl-077153	Oryza glaberrima	53.80	5.00e-106	375.00
IUUC-Ogu-078540	Oryza glumaepatula	53.94	9.00e-107	378.00
IUUC-Oin-079612	Oryza indica	53.13	6.00e-105	372.00
IUUC-Olo-081077	Oryza longistaminata	53.13	6.00e-105	372.00
IUUC-Ome-081236	Oryza meridionalis	52.84	9.00e-105	371.00
IUUC-Oni-082499	Oryza nivara	53.94	9.00e-107	378.00
IUUC-Opu-083499	Oryza punctata	53.13	6.00e-105	372.00
IUUC-Oru-084276	Oryza rufipogon	53.94	9.00e-107	378.00
IUUC-Osa-085849	Oryza sativa	53.94	9.00e-107	378.00
IUUC-Ola-086655	Oryzias latipes	50.15	2.00e-103	367.00
IUUC-Olu-087637	Ostreococcus lucimarinus	51.08	2.00e-108	383.00
IUUC-Oga-087934	Otolemur garnettii	50.15	2.00e-104	370.00
IUUC-Oar-090185	Ovis aries	50.45	1.00e-104	371.00
IUUC-Ptr-091198	Pan troglodytes	50.15	2.00e-104	370.00
IUUC-Pan-092622	Papio anubis	50.15	2.00e-104	370.00
IUUC-Psi-093320	Pelodiscus sinensis	49.85	4.00e-104	369.00
IUUC-Pma-094638	Petromyzon marinus	49.55	1.00e-102	365.00
IUUC-Pno-094826	Phaeosphaeria nodorum	47.63	2.00e-94	337.00
IUUC-Ppa-095783	Physcomitrella patens	53.92	1.00e-101	361.00
IUUC-Pfo-096894	Poecilia formosa	50.76	8.00e-104	368.00
IUUC-Pab-098020	Pongo abelii	50.15	1.00e-104	371.00
IUUC-Pop-099180	Populus trichocarpa	52.35	9.00e-100	355.00
IUUC-Pca-100909	Procavia capensis	53.31	6.00e-85	305.00
IUUC-Ppe-101346	Prunus persica	51.52	3.00e-104	370.00
IUUC-Pva-102167	Pteropus vampyrus	44.41	4.00e-86	310.00
IUUC-Pgr-103516	Puccinia graminis	47.97	6.00e-103	365.00
IUUC-Ptt-103738	Puccinia triticina	52.31	6.00e-102	362.00
IUUC-Pte-104352	Pyrenophora teres	56.51	1.00e-119	421.00
IUUC-Pyt-104632	Pyrenophora triticirepentis	55.92	3.00e-119	419.00
IUUC-Rno-105291	Rattus norvegicus	50.15	6.00e-104	369.00
IUUC-Sha-106943	Sarcophilus harrisii	48.79	9.00e-101	358.00
IUUC-Sja-107659	Schizosaccharomyces japonicus	60.56	5.00e-114	402.00
IUUC-Spo-108049	Schizosaccharomyces pombe	55.08	8.00e-113	398.00
IUUC-Smo-109043	Selaginella moellendorffii	52.12	2.00e-104	370.00
IUUC-Sit-110431	Setaria italica	53.33	2.00e-106	377.00
IUUC-Sly-111391	Solanum lycopersicum	51.41	3.00e-99	353.00
IUUC-Stu-112364	Solanum tuberosum	48.20	7.00e-81	291.00
IUUC-Sar-113450	Sorex araneus	50.45	3.00e-104	370.00
IUUC-Sbi-113829	Sorghum bicolor	48.71	1.00e-107	381.00
IUUC-Sre-115153	Sporisorium reilianum	52.44	3.00e-105	373.00
IUUC-Ssc-116274	Sus scrofa	50.15	2.00e-104	370.00
IUUC-Tgu-117417	Taeniopygia guttata	50.15	3.00e-104	370.00
IUUC-Tru-117615	Takifugu rubripes	48.64	2.00e-96	344.00
IUUC-Tsy-119480	Tarsius syrichta	50.15	2.00e-104	370.00
IUUC-Tni-119847	Tetraodon nigroviridis	49.24	2.00e-102	363.00
IUUC-Tca-121287	Theobroma cacao	53.03	8.00e-107	378.00
IUUC-Tre-122010	Trichoderma reesei	58.48	1.00e-122	431.00
IUUC-Tvi-122475	Trichoderma virens	56.73	2.00e-122	430.00
IUUC-Tae-124397	Triticum aestivum	49.33	1.00e-107	381.00
IUUC-Tur-126116	Triticum urartu	39.43	5.00e-79	286.00
IUUC-Tme-126992	Tuber melanosporum	56.86	4.00e-122	429.00
IUUC-Tbe-127803	Tupaia belangeri	54.47	2.00e-83	300.00
IUUC-Ttr-128933	Tursiops truncatus	50.15	2.00e-104	370.00
IUUC-Uma-129447	Ustilago maydis	52.10	3.00e-103	367.00
IUUC-Vda-129780	Verticillium dahliae	56.61	1.00e-122	431.00
IUUC-Vpa-130557	Vicugna pacos	33.50	6.00e-32	130.00
IUUC-Vvi-130918	Vitis vinifera	50.16	2.00e-98	350.00
IUUC-Xtr-132409	Xenopus tropicalis	50.76	2.00e-105	374.00
IUUC-Xma-133420	Xiphophorus maculatus	50.45	7.00e-104	369.00
IUUC-Yli-134362	Yarrowia lipolytica	54.36	2.00e-117	413.00
IUUC-Zma-135804	Zea mays	47.21	2.00e-105	373.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence