iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062178

UUCD1 version

UUC-MoD-00921

Ensembl Protein ID

ENSMODP00000010094.3

UniProt Accession

F7FV33; F7FV33_MONDO

Protein Name

Uncharacterized protein

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000008121.3	ENSMODT00000010289.3	ENSMODP00000010094.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.10e-131	437.2	1046	1384

Active Site

Position(s)	Description	Evidence
1354	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 1046 FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1132
           5799*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd+e+y+slk+i+en   d   ++ldl+fsv+ee++g+t+++eLk gG++i Vtn+Nk+eY++lv
   Q: 1133 FFIRPFYKMMLHKPITLHDMESVDSEYYNSLKWILEN---DP--AELDLRFSVDEELFGQTYQHELKNGGSEIVVTNKNKKEYIHLV 1214
           ***********************************99...44..4589*************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFw.........evlee 255
           +++r+ ++i++q+ af+eGf e+ip++l+++F+e+elell+cG  +idv+d++++tkyk+gy+ ++++iqwFw         +++ +
   Q: 1215 IQWRFVNRIQKQMSAFKEGFFELIPQNLIKIFDENELELLMCGLGDIDVNDWREHTKYKNGYSVNHQVIQWFWkarffffnlQAVLM 1301
           *************************************************************************3333333333699* PP
   S: 256  fsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           ++se+r ++LqFvTg+sr+P++Gfael     p++f+++++++ ++lP+++TCfn+L+LP+Y+s e l +kL++Aie+t+gF+
   Q: 1302 MDSEKRIRLLQFVTGTSRVPMNGFAELYgsngPQFFTVEQWGTSEKLPRAHTCFNRLDLPPYESFEDLWDKLQIAIENTQGFD 1384
           **********************************************************************************8 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MAQMLQLHVA ARRRNTCLLL ETSGDELNNS AHMSFKRSTE ISASSIIHMK LTPRLPPQTQ 60
EKSKPQERPT EPSSQNISKK STFLRISLQP TRNNRYLKSG NVTGEDATST CVLKEGIYSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATAACTTG ACTGAGTTCC TGGTAGGGTT ACTGTTTGGA AATTCAATCC TTCATTTGAT 60
ACTCAGTTAA ATAGGACTTC ATTCCTACTG ACTTCCTGTA ATTCTATCCT TTGGATAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0044111--P:development involved in symbiotic interaction
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0031175--P:neuron projection development
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011138	Astyanax mexicanus	82.30	0.00e+00	844.00
IUUC-Bta-012453	Bos taurus	86.88	0.00e+00	922.00
IUUC-Cja-019034	Callithrix jacchus	88.89	0.00e+00	966.00
IUUC-Csv-026098	Ciona savignyi	56.27	0.00e+00	648.00
IUUC-Dno-029159	Dasypus novemcinctus	58.42	0.00e+00	1403.00
IUUC-Dme-032166	Drosophila melanogaster	63.35	0.00e+00	701.00
IUUC-Ete-032409	Echinops telfairi	80.16	0.00e+00	853.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	85.40	0.00e+00	886.00
IUUC-Lch-050445	Latimeria chalumnae	51.24	0.00e+00	1247.00
IUUC-Meu-056897	Macropus eugenii	93.58	2.00e-170	593.00
IUUC-Mmr-061061	Microcebus murinus	64.34	0.00e+00	1644.00
IUUC-Oga-088241	Otolemur garnettii	54.81	0.00e+00	1275.00
IUUC-Oar-089797	Ovis aries	87.75	0.00e+00	923.00
IUUC-Ptr-091629	Pan troglodytes	88.89	0.00e+00	962.00
IUUC-Pca-100568	Procavia capensis	67.10	0.00e+00	839.00
IUUC-Tru-117675	Takifugu rubripes	80.12	0.00e+00	829.00
IUUC-Tbe-127408	Tupaia belangeri	82.10	0.00e+00	838.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence