iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-035991

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Breast cancer type 1 susceptibility protein homolog

Genbank Nucleotide ID

AANG02057667

Gene Name

BRCA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000013146.3	ENSFCAT00000013150.3	ENSFCAP00000012193.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-07	31.9	24	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n+ ++  +CPlC+
   Q: 24   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQRKGPSQCPLCK 65
           ********99.**************9666...68999********7 PP

Organism

Felis catus

Functional Description
(View)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.

Protein Sequence
(Fasta)

MDLSADRVEE VQSVLNAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQRKGPSQ 60
CPLCKNDITK RSLQESTRFS QLVEELLNII HAFELDTGLQ FANSYNFSKK ENNSPEHLKE 120

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Nucleotide Sequence
(Fasta)

GGAGAAATGG ATTTATCTGC AGATCGTGTT GAAGAAGTAC AAAGTGTCCT TAATGCTATG 60
CAGAAAATCT TAGAGTGTCC AATCTGGTAA GTCAACAGAA GGGTTTCTTA ATTTGAGATT 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4

PRINTS

PR00493--BRSTCANCERI

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0035066--P:positive regulation of histone acetylation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0042127--P:regulation of cell proliferation
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	82.12	0.00e+00	2972.00
IUUC-Apl-003252	Anas platyrhynchos	35.92	2.00e-119	424.00
IUUC-Aca-004526	Anolis carolinensis	58.93	1.00e-78	287.00
IUUC-Ame-011720	Astyanax mexicanus	47.29	5.00e-53	203.00
IUUC-Bgr-011969	Blumeria graminis	40.74	7.00e-09	55.10
IUUC-Bta-013433	Bos taurus	73.77	0.00e+00	2582.00
IUUC-Cel-018208	Caenorhabditis elegans	32.61	1.00e-10	61.20
IUUC-Cja-019149	Callithrix jacchus	74.52	0.00e+00	2581.00
IUUC-Cfa-020322	Canis familiaris	81.42	0.00e+00	2917.00
IUUC-Cpo-021583	Cavia porcellus	46.54	0.00e+00	1295.00
IUUC-Cre-022597	Chlamydomonas reinhardtii	32.50	3.00e-09	56.20
IUUC-Csa-024227	Chlorocebus sabaeus	73.77	9.00e-154	536.00
IUUC-Cho-024530	Choloepus hoffmanni	68.06	0.00e+00	1193.00
IUUC-Cin-025364	Ciona intestinalis	34.18	5.00e-16	78.20
IUUC-Csv-026245	Ciona savignyi	37.18	5.00e-13	67.80
IUUC-Dno-029247	Dasypus novemcinctus	70.54	0.00e+00	2040.00
IUUC-Dme-032032	Drosophila melanogaster	54.35	6.00e-11	58.50
IUUC-Ete-032472	Echinops telfairi	55.25	0.00e+00	1675.00
IUUC-Eca-033446	Equus caballus	79.37	0.00e+00	2876.00
IUUC-Eeu-034858	Erinaceus europaeus	63.16	0.00e+00	1007.00
IUUC-Fal-036803	Ficedula albicollis	62.33	3.00e-83	304.00
IUUC-Gmo-038782	Gadus morhua	46.88	9.00e-47	182.00
IUUC-Ggr-039833	Gaeumannomyces graminis	38.78	5.00e-08	52.40
IUUC-Gga-040969	Gallus gallus	53.36	4.00e-81	297.00
IUUC-Gac-042296	Gasterosteus aculeatus	46.89	6.00e-54	206.00
IUUC-Ggo-044740	Gorilla gorilla	72.36	0.00e+00	2476.00
IUUC-Hsa-046086	Homo sapiens	75.23	0.00e+00	2567.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	71.72	0.00e+00	2585.00
IUUC-Lch-049789	Latimeria chalumnae	35.76	4.00e-89	323.00
IUUC-Loc-051952	Lepisosteus oculatus	57.21	4.00e-71	263.00
IUUC-Laf-053648	Loxodonta africana	73.26	0.00e+00	2485.00
IUUC-Mcc-055210	Macaca mulatta	74.50	0.00e+00	2630.00
IUUC-Meu-056342	Macropus eugenii	38.10	3.00e-121	431.00
IUUC-Mor-057034	Magnaporthe oryzae	33.33	9.00e-09	54.70
IUUC-Mpo-057316	Magnaporthe poae	41.30	3.00e-08	53.10
IUUC-Mga-060163	Meleagris gallopavo	33.85	7.00e-114	405.00
IUUC-Mmr-061402	Microcebus murinus	69.42	0.00e+00	804.00
IUUC-Mdo-062209	Monodelphis domestica	45.09	0.00e+00	1228.00
IUUC-Mmu-064003	Mus musculus	53.54	0.00e+00	1706.00
IUUC-Mpu-065825	Mustela putorius furo	79.67	0.00e+00	878.00
IUUC-Mlu-068176	Myotis lucifugus	73.51	0.00e+00	2504.00
IUUC-Nle-069178	Nomascus leucogenys	75.28	0.00e+00	2607.00
IUUC-Opr-070574	Ochotona princeps	59.73	0.00e+00	1936.00
IUUC-Ont-072380	Oreochromis niloticus	50.00	2.00e-59	224.00
IUUC-Oan-073243	Ornithorhynchus anatinus	76.19	4.00e-35	140.00
IUUC-Ocu-074424	Oryctolagus cuniculus	68.28	0.00e+00	2346.00
IUUC-Ola-086863	Oryzias latipes	50.24	8.00e-57	216.00
IUUC-Oar-089938	Ovis aries	73.84	0.00e+00	2634.00
IUUC-Ptr-090960	Pan troglodytes	75.71	0.00e+00	2604.00
IUUC-Pan-092609	Papio anubis	73.29	0.00e+00	2270.00
IUUC-Psi-093889	Pelodiscus sinensis	29.05	2.00e-45	177.00
IUUC-Pfo-096328	Poecilia formosa	50.22	8.00e-62	232.00
IUUC-Pab-097982	Pongo abelii	75.44	0.00e+00	2621.00
IUUC-Pca-100698	Procavia capensis	65.26	0.00e+00	673.00
IUUC-Pva-102631	Pteropus vampyrus	78.40	0.00e+00	1248.00
IUUC-Rno-105879	Rattus norvegicus	53.64	0.00e+00	1682.00
IUUC-Sha-106701	Sarcophilus harrisii	38.68	0.00e+00	647.00
IUUC-Spo-108335	Schizosaccharomyces pombe	34.83	1.00e-10	61.20
IUUC-Sit-110609	Setaria italica	32.19	3.00e-18	87.80
IUUC-Sar-113047	Sorex araneus	64.53	0.00e+00	1561.00
IUUC-Ssc-115846	Sus scrofa	76.09	0.00e+00	2751.00
IUUC-Tgu-116785	Taeniopygia guttata	30.50	3.00e-94	340.00
IUUC-Tru-117895	Takifugu rubripes	42.80	8.00e-54	206.00
IUUC-Tsy-118885	Tarsius syrichta	56.66	0.00e+00	676.00
IUUC-Tni-119654	Tetraodon nigroviridis	45.15	2.00e-51	198.00
IUUC-Tbe-127421	Tupaia belangeri	59.39	2.00e-148	521.00
IUUC-Ttr-128685	Tursiops truncatus	78.36	0.00e+00	2666.00
IUUC-Vpa-130216	Vicugna pacos	72.74	0.00e+00	897.00
IUUC-Xtr-132398	Xenopus tropicalis	54.81	6.00e-58	219.00
IUUC-Xma-133651	Xiphophorus maculatus	52.12	2.00e-46	181.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence