iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-106701

Ensembl Protein ID

ENSSHAP00000013295.1

UniProt Accession

G3WCZ0; G3WCZ0_SARHA

Genbank Protein ID

ENSSHAP00000013295

Protein Name

Breast cancer type 1 susceptibility protein homolog

Genbank Nucleotide ID

AEFK01162169

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000011367.1	ENSSHAT00000013404.1	ENSSHAP00000013295.1
ENSSHAG00000011367.1	ENSSHAT00000013405.1	ENSSHAP00000013296.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	38.94	0.00e+00	692.00	IUUC-Hsa-046086

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Sarcophilus harrisii

Functional Description
(View)

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.

Protein Sequence
(Fasta)

QHHSNTKDAH VIEENATGGH PKEPQSISSS NLNMKPCGTD THASSLLPET STLLPNTDRM 60
TVEKAELCNK SKQSGLARNQ QSGLDESKGI CSTGKTPSVE EQPELNAHHL CEKQELKEKP 120

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Nucleotide Sequence
(Fasta)

CAGCATCATT CTAATACCAA AGATGCTCAC GTCATTGAGG AGAATGCCAC TGGGGGACAT 60
CCAAAGGAGC CTCAGAGTAT TTCTTCTTCA AACTTGAATA TGAAGCCATG TGGCACAGAC 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom

Pfam

PF12820--BRCT_assoc

PRINTS

PR00493--BRSTCANCERI

Gene Ontology

GO:0031436--C:BRCA1-BARD1 complex
GO:0005694--C:chromosome
GO:0003677--F:DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002388	Ailuropoda melanoleuca	39.18	3.00e-140	493.00
IUUC-Apl-003252	Anas platyrhynchos	33.22	3.00e-71	264.00
IUUC-Aca-004526	Anolis carolinensis	71.64	1.00e-22	101.00
IUUC-Ame-011720	Astyanax mexicanus	71.01	5.00e-24	107.00
IUUC-Bta-013433	Bos taurus	39.10	0.00e+00	676.00
IUUC-Bol-016476	Brassica oleracea	39.71	8.00e-10	59.30
IUUC-Bra-017176	Brassica rapa	39.71	2.00e-10	61.20
IUUC-Cja-019149	Callithrix jacchus	39.63	0.00e+00	677.00
IUUC-Cfa-020322	Canis familiaris	38.76	0.00e+00	696.00
IUUC-Cpo-021583	Cavia porcellus	31.33	9.00e-104	372.00
IUUC-Csa-024227	Chlorocebus sabaeus	46.98	3.00e-63	236.00
IUUC-Cho-024530	Choloepus hoffmanni	41.00	1.00e-112	402.00
IUUC-Dno-029247	Dasypus novemcinctus	41.77	0.00e+00	756.00
IUUC-Ete-032472	Echinops telfairi	32.58	4.00e-75	277.00
IUUC-Eca-033446	Equus caballus	41.59	0.00e+00	781.00
IUUC-Eeu-034858	Erinaceus europaeus	37.05	5.00e-79	290.00
IUUC-Fca-035991	Felis catus	39.10	0.00e+00	699.00
IUUC-Fal-036803	Ficedula albicollis	70.24	6.00e-29	123.00
IUUC-Gmo-038782	Gadus morhua	60.00	2.00e-15	78.60
IUUC-Gga-040969	Gallus gallus	74.32	1.00e-28	122.00
IUUC-Gac-042296	Gasterosteus aculeatus	54.55	3.00e-17	84.30
IUUC-Gma-044371	Glycine max	36.23	5.00e-09	56.20
IUUC-Ggo-044740	Gorilla gorilla	36.94	5.00e-179	622.00
IUUC-Hsa-046086	Homo sapiens	38.72	0.00e+00	650.00
IUUC-Itr-048512	Ictidomys tridecemlineatus	39.87	0.00e+00	718.00
IUUC-Lch-049789	Latimeria chalumnae	39.20	7.00e-44	173.00
IUUC-Loc-051952	Lepisosteus oculatus	68.92	2.00e-25	111.00
IUUC-Laf-053648	Loxodonta africana	38.69	0.00e+00	662.00
IUUC-Mcc-055210	Macaca mulatta	39.19	0.00e+00	681.00
IUUC-Meu-056342	Macropus eugenii	62.95	0.00e+00	1004.00
IUUC-Mga-060163	Meleagris gallopavo	33.39	5.00e-54	207.00
IUUC-Mmr-061402	Microcebus murinus	43.90	2.00e-72	266.00
IUUC-Mdo-062209	Monodelphis domestica	62.28	0.00e+00	1550.00
IUUC-Mmu-064003	Mus musculus	35.69	6.00e-144	506.00
IUUC-Mpu-065825	Mustela putorius furo	47.83	1.00e-74	274.00
IUUC-Mlu-068176	Myotis lucifugus	38.15	0.00e+00	647.00
IUUC-Nle-069178	Nomascus leucogenys	38.24	0.00e+00	648.00
IUUC-Opr-070574	Ochotona princeps	35.66	1.00e-157	551.00
IUUC-Ont-072380	Oreochromis niloticus	58.82	3.00e-21	97.80
IUUC-Ocu-074424	Oryctolagus cuniculus	38.66	0.00e+00	673.00
IUUC-Ola-086863	Oryzias latipes	53.95	2.00e-20	95.10
IUUC-Oar-089938	Ovis aries	38.39	0.00e+00	687.00
IUUC-Ptr-090960	Pan troglodytes	38.74	0.00e+00	660.00
IUUC-Pan-092609	Papio anubis	39.89	0.00e+00	696.00
IUUC-Psi-093889	Pelodiscus sinensis	32.80	2.00e-30	128.00
IUUC-Pfo-096328	Poecilia formosa	58.82	8.00e-21	96.30
IUUC-Pab-097982	Pongo abelii	39.20	0.00e+00	673.00
IUUC-Pca-100698	Procavia capensis	44.04	3.00e-53	204.00
IUUC-Pva-102631	Pteropus vampyrus	40.72	6.00e-87	316.00
IUUC-Rno-105879	Rattus norvegicus	35.42	3.00e-147	516.00
IUUC-Sar-113047	Sorex araneus	35.48	2.00e-114	407.00
IUUC-Ssc-115846	Sus scrofa	38.86	0.00e+00	698.00
IUUC-Tgu-116785	Taeniopygia guttata	77.94	5.00e-28	120.00
IUUC-Tru-117895	Takifugu rubripes	54.05	1.00e-19	92.80
IUUC-Tsy-118885	Tarsius syrichta	36.57	3.00e-44	174.00
IUUC-Tni-119654	Tetraodon nigroviridis	58.82	2.00e-20	95.10
IUUC-Tre-122219	Trichoderma reesei	26.00	2.40e+00	26.90
IUUC-Tur-126725	Triticum urartu	32.20	1.00e-09	58.90
IUUC-Tbe-127421	Tupaia belangeri	37.98	2.00e-49	191.00
IUUC-Ttr-128685	Tursiops truncatus	40.27	0.00e+00	664.00
IUUC-Vpa-130216	Vicugna pacos	38.98	3.00e-72	267.00
IUUC-Xtr-132398	Xenopus tropicalis	36.83	4.00e-33	137.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence