iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133031

Ensembl Protein ID

ENSXMAP00000009749.1

UniProt Accession

M4A5K5; M4A5K5_XIPMA

Genbank Protein ID

ENSXMAP00000009749

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AGAJ01006046

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000009720.1	ENSXMAT00000009763.1	ENSXMAP00000009749.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-14	54.0	88	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG+  +++  ++++++W+++ + ++g  G +P+n+v+ ++
   Q: 88   FVALYDYEARTEDDLSFRKGERFQIL--NSTEGDWWEARSLTTGGTGYIPSNYVAPVD 143
           789***********************..8999**********************9987 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

RMGCVQCKDK EAAKLTDDRE TSLTHSSGYR YGSDPTPQHY PSFGVTTIPN YNNFHTAATQ 60
GVTVFGGVHT SSQSGTLRSR GGTGVTLFVA LYDYEARTED DLSFRKGERF QILNSTEGDW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGATGGGCT GTGTCCAATG TAAGGATAAA GAAGCAGCGA AACTCACCGA TGACCGCGAG 60
ACCAGCCTCA CTCACAGCTC GGGGTACCGC TATGGCTCCG ACCCCACGCC GCAGCACTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0034334--P:adherens junction maintenance
GO:0060027--P:convergent extension involved in gastrulation
GO:0001702--P:gastrulation with mouth forming second
GO:0042552--P:myelination
GO:0046777--P:protein autophosphorylation
GO:0051480--P:regulation of cytosolic calcium ion concentration
GO:0045859--P:regulation of protein kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002009	Ailuropoda melanoleuca	92.18	0.00e+00	1023.00
IUUC-Apl-003716	Anas platyrhynchos	86.83	0.00e+00	949.00
IUUC-Aca-005065	Anolis carolinensis	92.55	0.00e+00	1024.00
IUUC-Ame-011533	Astyanax mexicanus	97.80	0.00e+00	933.00
IUUC-Bta-012645	Bos taurus	92.18	0.00e+00	1022.00
IUUC-Cel-018682	Caenorhabditis elegans	57.68	7.00e-149	520.00
IUUC-Cja-019027	Callithrix jacchus	92.18	0.00e+00	1023.00
IUUC-Cfa-021163	Canis familiaris	92.18	0.00e+00	1023.00
IUUC-Cpo-022315	Cavia porcellus	92.18	0.00e+00	1023.00
IUUC-Csa-023721	Chlorocebus sabaeus	92.18	0.00e+00	1024.00
IUUC-Cho-025014	Choloepus hoffmanni	92.36	0.00e+00	1025.00
IUUC-Dre-027985	Danio rerio	94.79	0.00e+00	1076.00
IUUC-Dno-030043	Dasypus novemcinctus	77.53	0.00e+00	903.00
IUUC-Dor-031035	Dipodomys ordii	90.88	0.00e+00	1003.00
IUUC-Dme-031976	Drosophila melanogaster	61.71	7.00e-167	580.00
IUUC-Eeu-034582	Erinaceus europaeus	89.91	0.00e+00	633.00
IUUC-Fca-035582	Felis catus	92.18	0.00e+00	1023.00
IUUC-Fal-037320	Ficedula albicollis	87.15	0.00e+00	954.00
IUUC-Gmo-038992	Gadus morhua	95.55	0.00e+00	1070.00
IUUC-Gga-041262	Gallus gallus	87.15	0.00e+00	954.00
IUUC-Gac-042461	Gasterosteus aculeatus	97.02	0.00e+00	1097.00
IUUC-Ggo-044469	Gorilla gorilla	91.26	0.00e+00	1019.00
IUUC-Hsa-045723	Homo sapiens	92.18	0.00e+00	1024.00
IUUC-Itr-048519	Ictidomys tridecemlineatus	92.18	0.00e+00	1023.00
IUUC-Lch-049825	Latimeria chalumnae	90.88	0.00e+00	1001.00
IUUC-Laf-053659	Loxodonta africana	92.18	0.00e+00	1022.00
IUUC-Mcc-055039	Macaca mulatta	86.35	0.00e+00	950.00
IUUC-Mga-060067	Meleagris gallopavo	92.57	0.00e+00	1023.00
IUUC-Mmr-061194	Microcebus murinus	92.18	0.00e+00	1023.00
IUUC-Mdo-062628	Monodelphis domestica	92.36	0.00e+00	1025.00
IUUC-Mmu-063896	Mus musculus	92.55	0.00e+00	1026.00
IUUC-Mpu-066333	Mustela putorius furo	92.55	0.00e+00	1027.00
IUUC-Mlu-067315	Myotis lucifugus	92.18	0.00e+00	1023.00
IUUC-Nle-068978	Nomascus leucogenys	86.78	0.00e+00	952.00
IUUC-Ont-072516	Oreochromis niloticus	98.51	0.00e+00	1115.00
IUUC-Oan-073714	Ornithorhynchus anatinus	94.73	0.00e+00	911.00
IUUC-Ocu-074284	Oryctolagus cuniculus	92.18	0.00e+00	1024.00
IUUC-Ola-087431	Oryzias latipes	98.88	0.00e+00	1112.00
IUUC-Oga-088789	Otolemur garnettii	86.59	0.00e+00	948.00
IUUC-Oar-089408	Ovis aries	92.18	0.00e+00	1022.00
IUUC-Ptr-091068	Pan troglodytes	92.18	0.00e+00	1024.00
IUUC-Pan-092217	Papio anubis	92.18	0.00e+00	1024.00
IUUC-Psi-093602	Pelodiscus sinensis	92.36	0.00e+00	1024.00
IUUC-Pfo-097084	Poecilia formosa	99.81	0.00e+00	1122.00
IUUC-Pab-097673	Pongo abelii	91.81	0.00e+00	1020.00
IUUC-Pca-100245	Procavia capensis	91.56	0.00e+00	923.00
IUUC-Pva-102645	Pteropus vampyrus	90.86	0.00e+00	992.00
IUUC-Rno-105372	Rattus norvegicus	92.36	0.00e+00	1025.00
IUUC-Sha-107637	Sarcophilus harrisii	92.36	0.00e+00	1020.00
IUUC-Sar-113016	Sorex araneus	81.56	0.00e+00	882.00
IUUC-Ssc-116389	Sus scrofa	91.99	0.00e+00	1022.00
IUUC-Tgu-117206	Taeniopygia guttata	87.15	0.00e+00	954.00
IUUC-Tru-118241	Takifugu rubripes	97.78	0.00e+00	1103.00
IUUC-Tni-120031	Tetraodon nigroviridis	98.70	0.00e+00	1105.00
IUUC-Tbe-127707	Tupaia belangeri	90.85	0.00e+00	923.00
IUUC-Ttr-129145	Tursiops truncatus	92.18	0.00e+00	1023.00
IUUC-Vpa-130815	Vicugna pacos	89.70	0.00e+00	971.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence