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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-032019
UUCD1 version UUC-DrM-00184
Ensembl Protein ID FBpp0087307
UniProt Accession Q7K4B3; ELP2_DROME
Genbank Protein ID AAF58765.2; AAK93443.1
Protein Name Probable elongator complex protein 2; Stat3-interacting protein homolog
Genbank Nucleotide ID AE013599; AY052019
Gene Name Elp2; StIP; CG11887
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0033540 FBtr0088212 FBpp0087307
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
Protein-protein Interaction
IIDiRefIndexPINA
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.60e-41 136.6 203 235
UBD/Beta-Prp 9.00e-48 163.0 55 367
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWD 29
           gH+d+v++l+f     d ll+sGs D+ i++W+
   Q: 203  GHEDWVRGLDFvvdgEDLLLASGSQDNFIRLWR 235
           8***********96433779************9 PP
   

   UBD/Beta-Prp
   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgk...ilvtgseDrtikvwdls..tgkcvhtlkghedsv 97
           +h k  ++ v + + ++ l++g++d+  ++w++++  + +s+  +gh+++v++v+ +++++   +l+t++ D tik+w ++  ++ c++t++  +   
   Q: 55   EHTKR-VNTVRWLDCDK-LLSGGDDAIAILWELDETGTTKSFtlKGHTSGVNTVDGIRQQDgswLLATAAADTTIKLWTFQdnNYVCFQTISLSDGFC 150
           44454.44477766665.8899999999*****99988655444*************999999***************87766999******777777 PP
   S: 98   lslsfsp....sgdklvsGshdrtirvwdletgqclee...........tlsghdgvvncvvvhpdg..nllvsGslDrtvrlWdl............ 166
            +l+++     ++  l+  ++d+t+ +w  + ++  e             l+gh+++v+++ +  dg   ll+sGs D+++rlW++            
   Q: 151  FCLRLQLlpksNQVLLAFSGDDETVSLWSEQVETAGEGdslgrqfqrkhKLTGHEDWVRGLDFVVDGedLLLASGSQDNFIRLWRIaprskeqmqenr 248
           77555444474456667778899*****666666665599*******************9976555443899********************999888 PP
   S: 167  ...........................ktgkllrtltgghtdsvyslsfdsng...kelvsgsldgtvklwdlq......tgecvrtlnghtdnvksv 228
                                         +l   l  gh++ +y + ++++     +l+s+s d+tv++w         ++  v ++ g +  ++  
   Q: 249  vdlhqlshnddeikveekilqlgkeawYAVSLESVLY-GHEGWIYGVHWHKTPdqeLRLLSASIDKTVIIWAPTeegiwlEEVRVGEVGGNSVGFYGG 345
           8888888888888777777777766643444444444.48888888887766566789*************998555555444499999999999999 PP
   S: 229  rfspnderlvsgssDgsiriWd 250
           +fs +++ ++  s  g   iW 
   Q: 346  KFSGDGHSIMAHSYQGGFHIWS 367
           9999999999999999999994 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (By similarity). Involved in the regulation of the STAT pathway.
 Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (By similarity). Involved in the regulation of the STAT pathway.
Protein Sequence
(Fasta)
MQVENLHTSV ACNRCTECAD WGPNGWIAYG ACNAIAIMDP KFQGNSAKVL FTLVEHTKRV 60
NTVRWLDCDK LLSGGDDAIA ILWELDETGT TKSFTLKGHT SGVNTVDGIR QQDGSWLLAT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032019|E3,WD_repeat;UBD,Beta-Prp|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGACAGTTT TAGAAGCACT GCATTATTTG AAGCACATGT GCCAAAACAA AACAATTTCG 60
CCGACATTCA ATTCGAATTT AGTTGTCATT AAAAAATAGA AGTGCAACAT TAGCATGCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032019|E3,WD_repeat;UBD,Beta-Prp|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0061133--F:endopeptidase activator activity
GO:0008017--F:microtubule binding
GO:0043248--P:proteasome assembly
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006368--P:transcription elongation from RNA polymerase II promoter
KEGG dme:Dmel_CG11887
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000056 Aegilops tauschii 32.23 3.00e-109 388.00
IUUC-Aml-002049 Ailuropoda melanoleuca 40.26 7.00e-154 536.00
IUUC-Atr-002456 Amborella trichopoda 35.16 3.00e-128 451.00
IUUC-Apl-004053 Anas platyrhynchos 43.18 0.00e+00 644.00
IUUC-Aca-004535 Anolis carolinensis 41.63 2.00e-149 522.00
IUUC-Aly-005746 Arabidopsis lyrata 33.45 4.00e-120 425.00
IUUC-Ath-006664 Arabidopsis thaliana 33.26 2.00e-118 419.00
IUUC-Ago-007971 Ashbya gossypii 33.21 3.00e-101 362.00
IUUC-Acl-008173 Aspergillus clavatus 34.24 2.00e-111 396.00
IUUC-Afl-008665 Aspergillus flavus 29.85 1.00e-43 170.00
IUUC-Afu-008976 Aspergillus fumigatus 34.59 4.00e-115 408.00
IUUC-Ani-009284 Aspergillus nidulans 32.86 5.00e-105 375.00
IUUC-Ang-009809 Aspergillus niger 33.69 1.00e-112 399.00
IUUC-Aor-009959 Aspergillus oryzae 33.65 5.00e-108 384.00
IUUC-Ate-010442 Aspergillus terreus 32.82 1.00e-113 403.00
IUUC-Ame-011409 Astyanax mexicanus 40.89 2.00e-180 625.00
IUUC-Bgr-012137 Blumeria graminis 34.37 3.00e-111 395.00
IUUC-Bta-012892 Bos taurus 41.29 0.00e+00 627.00
IUUC-Bci-013944 Botrytis cinerea 30.93 2.00e-96 346.00
IUUC-Bdi-014512 Brachypodium distachyon 32.68 4.00e-117 414.00
IUUC-Bol-015741 Brassica oleracea 34.35 5.00e-129 454.00
IUUC-Bra-017367 Brassica rapa 34.39 5.00e-129 454.00
IUUC-Cel-018712 Caenorhabditis elegans 31.43 5.00e-99 354.00
IUUC-Cja-018865 Callithrix jacchus 38.25 2.00e-171 595.00
IUUC-Cfa-021006 Canis familiaris 41.02 2.00e-180 625.00
IUUC-Cpo-021370 Cavia porcellus 40.90 2.00e-180 625.00
IUUC-Csa-023845 Chlorocebus sabaeus 40.24 1.00e-178 619.00
IUUC-Cho-024640 Choloepus hoffmanni 39.36 3.00e-106 378.00
IUUC-Cin-025772 Ciona intestinalis 38.94 7.00e-150 523.00
IUUC-Csv-025891 Ciona savignyi 38.17 4.00e-158 551.00
IUUC-Cgl-026443 Colletotrichum gloeosporioides 34.23 4.00e-105 375.00
IUUC-Cne-027081 Cryptococcus neoformans 34.37 1.00e-105 376.00
IUUC-Cme-027225 Cyanidioschyzon merolae 29.25 6.00e-45 175.00
IUUC-Dre-028250 Danio rerio 41.60 9.00e-180 622.00
IUUC-Dno-028847 Dasypus novemcinctus 40.43 3.00e-178 618.00
IUUC-Dor-030351 Dipodomys ordii 40.31 2.00e-174 605.00
IUUC-Dse-031317 Dothistroma septosporum 34.13 1.00e-102 367.00
IUUC-Ete-033194 Echinops telfairi 38.76 1.00e-94 340.00
IUUC-Eca-033779 Equus caballus 40.52 3.00e-177 614.00
IUUC-Eeu-034790 Erinaceus europaeus 43.25 2.00e-110 392.00
IUUC-Fca-036090 Felis catus 42.39 5.00e-174 603.00
IUUC-Fal-037663 Ficedula albicollis 40.58 1.00e-173 602.00
IUUC-Fox-037828 Fusarium oxysporum 32.17 3.00e-109 389.00
IUUC-Fso-038462 Fusarium solani 34.79 8.00e-112 397.00
IUUC-Gmo-039450 Gadus morhua 41.73 0.00e+00 626.00
IUUC-Ggr-040023 Gaeumannomyces graminis 31.60 2.00e-88 319.00
IUUC-Gga-040480 Gallus gallus 42.25 0.00e+00 663.00
IUUC-Gac-041544 Gasterosteus aculeatus 41.25 0.00e+00 629.00
IUUC-Gma-044048 Glycine max 34.37 5.00e-126 444.00
IUUC-Ggo-045381 Gorilla gorilla 38.51 3.00e-164 571.00
IUUC-Hsa-046096 Homo sapiens 38.76 3.00e-172 598.00
IUUC-Hvu-047494 Hordeum vulgare 32.21 2.00e-117 416.00
IUUC-Itr-048823 Ictidomys tridecemlineatus 40.65 6.00e-137 480.00
IUUC-Kpa-049241 Komagataella pastoris 32.27 2.00e-95 342.00
IUUC-Lch-050512 Latimeria chalumnae 44.05 2.00e-164 572.00
IUUC-Lpe-051448 Leersia perrieri 33.10 4.00e-122 431.00
IUUC-Loc-051882 Lepisosteus oculatus 42.86 0.00e+00 663.00
IUUC-Lma-053023 Leptosphaeria maculans 32.13 9.00e-102 363.00
IUUC-Laf-054519 Loxodonta africana 40.31 7.00e-178 616.00
IUUC-Mcc-055580 Macaca mulatta 38.01 6.00e-167 580.00
IUUC-Meu-056606 Macropus eugenii 41.44 4.00e-51 195.00
IUUC-Mor-057109 Magnaporthe oryzae 32.95 1.00e-110 393.00
IUUC-Mpo-057297 Magnaporthe poae 30.65 8.00e-97 347.00
IUUC-Mtr-058348 Medicago truncatula 34.14 8.00e-127 447.00
IUUC-Mla-059159 Melampsora laricipopulina 33.58 2.00e-87 316.00
IUUC-Mga-059778 Meleagris gallopavo 40.04 4.00e-116 410.00
IUUC-Mvi-060447 Microbotryum violaceum 31.76 5.00e-109 388.00
IUUC-Mmr-061139 Microcebus murinus 37.92 2.00e-171 595.00
IUUC-Mdo-061866 Monodelphis domestica 41.49 0.00e+00 648.00
IUUC-Mmu-063390 Mus musculus 41.30 1.00e-171 596.00
IUUC-Mac-064693 Musa acuminata 35.20 9.00e-131 460.00
IUUC-Mpu-066547 Mustela putorius furo 41.76 4.00e-176 610.00
IUUC-Mlu-067156 Myotis lucifugus 41.58 1.00e-180 625.00
IUUC-Nfi-068616 Neosartorya fischeri 34.83 6.00e-116 410.00
IUUC-Ncr-068915 Neurospora crassa 30.61 1.00e-97 350.00
IUUC-Nle-069958 Nomascus leucogenys 41.28 3.00e-175 607.00
IUUC-Opr-071093 Ochotona princeps 38.93 2.00e-80 293.00
IUUC-Ont-072178 Oreochromis niloticus 43.23 0.00e+00 658.00
IUUC-Oan-073667 Ornithorhynchus anatinus 39.67 2.00e-169 588.00
IUUC-Ocu-074662 Oryctolagus cuniculus 40.71 1.00e-180 625.00
IUUC-Oba-075577 Oryza barthii 33.72 2.00e-127 449.00
IUUC-Obr-076566 Oryza brachyantha 33.45 6.00e-128 451.00
IUUC-Ogl-077054 Oryza glaberrima 33.96 1.00e-127 449.00
IUUC-Ogu-078846 Oryza glumaepatula 33.72 1.00e-127 449.00
IUUC-Oin-079084 Oryza indica 33.84 1.00e-127 449.00
IUUC-Olo-080933 Oryza longistaminata 31.49 7.00e-106 377.00
IUUC-Ome-081500 Oryza meridionalis 31.88 9.00e-113 400.00
IUUC-Oni-082352 Oryza nivara 33.57 6.00e-126 444.00
IUUC-Opu-084116 Oryza punctata 32.75 3.00e-124 438.00
IUUC-Oru-085249 Oryza rufipogon 33.84 1.00e-127 449.00
IUUC-Osa-086270 Oryza sativa 33.84 1.00e-127 449.00
IUUC-Ola-086625 Oryzias latipes 38.92 1.00e-157 550.00
IUUC-Olu-087638 Ostreococcus lucimarinus 33.94 1.00e-87 316.00
IUUC-Oga-088634 Otolemur garnettii 36.80 3.00e-161 561.00
IUUC-Oar-089475 Ovis aries 41.07 3.00e-179 621.00
IUUC-Ptr-091131 Pan troglodytes 40.57 3.00e-179 621.00
IUUC-Pan-092869 Papio anubis 40.00 8.00e-178 616.00
IUUC-Psi-093146 Pelodiscus sinensis 44.07 7.00e-166 576.00
IUUC-Pma-094479 Petromyzon marinus 46.52 4.00e-159 554.00
IUUC-Pno-095061 Phaeosphaeria nodorum 32.67 5.00e-67 248.00
IUUC-Ppa-095618 Physcomitrella patens 33.60 2.00e-115 410.00
IUUC-Pfo-096816 Poecilia formosa 41.06 3.00e-180 624.00
IUUC-Pab-097548 Pongo abelii 40.73 0.00e+00 627.00
IUUC-Pop-099643 Populus trichocarpa 34.28 1.00e-128 453.00
IUUC-Pca-100983 Procavia capensis 37.90 5.00e-81 295.00
IUUC-Ppe-101301 Prunus persica 34.03 7.00e-127 447.00
IUUC-Pva-102460 Pteropus vampyrus 40.66 4.00e-174 604.00
IUUC-Pgr-103507 Puccinia graminis 30.95 3.00e-92 332.00
IUUC-Ptt-103892 Puccinia triticina 31.88 3.00e-76 279.00
IUUC-Pte-104283 Pyrenophora teres 32.18 2.00e-97 349.00
IUUC-Pyt-104465 Pyrenophora triticirepentis 32.06 2.00e-91 329.00
IUUC-Rno-105842 Rattus norvegicus 40.89 1.00e-173 602.00
IUUC-Sce-106459 Saccharomyces cerevisiae 31.32 1.00e-96 347.00
IUUC-Sha-106586 Sarcophilus harrisii 34.22 2.00e-129 456.00
IUUC-Sja-107868 Schizosaccharomyces japonicus 31.66 2.00e-91 329.00
IUUC-Spo-108302 Schizosaccharomyces pombe 31.55 5.00e-93 334.00
IUUC-Smo-108919 Selaginella moellendorffii 32.95 3.00e-123 435.00
IUUC-Sit-109915 Setaria italica 33.22 4.00e-124 438.00
IUUC-Sly-111714 Solanum lycopersicum 34.84 9.00e-130 457.00
IUUC-Stu-112631 Solanum tuberosum 34.65 1.00e-130 459.00
IUUC-Sar-113200 Sorex araneus 35.58 9.00e-144 503.00
IUUC-Sbi-114582 Sorghum bicolor 32.76 3.00e-120 425.00
IUUC-Sre-115001 Sporisorium reilianum 28.40 4.00e-44 173.00
IUUC-Ssc-115519 Sus scrofa 40.73 3.00e-176 611.00
IUUC-Tgu-116987 Taeniopygia guttata 42.09 0.00e+00 629.00
IUUC-Tru-118476 Takifugu rubripes 42.65 0.00e+00 639.00
IUUC-Tsy-119230 Tarsius syrichta 43.14 3.00e-78 285.00
IUUC-Tni-120448 Tetraodon nigroviridis 29.59 3.00e-80 292.00
IUUC-Tca-121650 Theobroma cacao 33.60 7.00e-126 444.00
IUUC-Tre-122086 Trichoderma reesei 34.23 1.00e-106 379.00
IUUC-Tvi-122397 Trichoderma virens 34.14 2.00e-102 365.00
IUUC-Tae-125778 Triticum aestivum 32.29 1.00e-119 423.00
IUUC-Tur-126578 Triticum urartu 32.55 1.00e-117 417.00
IUUC-Tme-126927 Tuber melanosporum 32.37 1.00e-99 356.00
IUUC-Tbe-127922 Tupaia belangeri 50.24 4.00e-57 215.00
IUUC-Ttr-128918 Tursiops truncatus 41.18 3.00e-179 621.00
IUUC-Uma-129474 Ustilago maydis 27.67 4.00e-49 189.00
IUUC-Vda-129944 Verticillium dahliae 32.62 3.00e-100 358.00
IUUC-Vpa-130693 Vicugna pacos 40.21 1.00e-173 602.00
IUUC-Vvi-130949 Vitis vinifera 34.98 2.00e-129 455.00
IUUC-Xtr-132639 Xenopus tropicalis 43.53 1.00e-163 569.00
IUUC-Xma-134223 Xiphophorus maculatus 45.53 2.00e-127 448.00
IUUC-Yli-134601 Yarrowia lipolytica 34.59 7.00e-99 353.00
IUUC-Zma-135952 Zea mays 32.98 5.00e-122 431.00
Created Date 25-Jun-2017

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