iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132776

UUCD1 version

UUC-XeT-01018

Ensembl Protein ID

ENSXETP00000054036.2

UniProt Accession

Q6GLG7; UBA5_XENTR

Genbank Protein ID

CAJ82881.1; AAH74525.1

Protein Name

Ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme; Ubiquitin-activating enzyme E1 domain-containing protein 1

Genbank Nucleotide ID

CR760171; BC074525

Gene Name

uba5; ube1dc1; TNeu098a04.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000025266.2	ENSXETT00000054036.2	ENSXETP00000054036.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	83.83	1.00e-162	570.00	IUUC-Hsa-046777

Active Site

Position(s)	Description	Evidence
246	Glycyl thioester intermediate	{ECO:0000250\|UniProtKB:Q9GZZ9}

Organism

Xenopus tropicalis

Functional Description
(View)

E1-like enzyme which activates UFM1 and SUMO2.

Protein Sequence
(Fasta)

MEKLIEELRS RVSELEEELH RVRNGEQVHE GHRAKINTMS AEVVDSNPYS RLMALKRMGI 60
VEDYEKIRTF TVAVVGVGGV GSVTAEMLTR CGIGKLLLFD YDKVEMANMN RLFFQPHQAG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTCCCTCCC TCTTCTTGCA TAGTGCAGAC GTGTCTCTAG GTTGGCGAAG AAAAGAGGCT 60
TCTGTTGGTA CCAATATTGC CCCAGAGTGG GCCCGCCAGT GAGTGGCCAG AAGAAAGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR029752--D-isomer_DH_CS1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0071566--F:UFM1 activating enzyme activity
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation

KEGG

xtr:448010

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001324	Ailuropoda melanoleuca	83.88	2.00e-161	561.00
IUUC-Atr-002660	Amborella trichopoda	57.56	6.00e-112	397.00
IUUC-Apl-003722	Anas platyrhynchos	86.65	5.00e-156	543.00
IUUC-Aca-004584	Anolis carolinensis	82.28	1.00e-160	558.00
IUUC-Aly-005881	Arabidopsis lyrata	55.93	4.00e-111	394.00
IUUC-Ath-007286	Arabidopsis thaliana	58.71	2.00e-115	409.00
IUUC-Ame-011679	Astyanax mexicanus	82.08	1.00e-137	481.00
IUUC-Bta-012517	Bos taurus	83.33	5.00e-167	580.00
IUUC-Bdi-014894	Brachypodium distachyon	60.59	6.00e-113	400.00
IUUC-Bol-016054	Brassica oleracea	62.21	3.00e-115	408.00
IUUC-Bra-016708	Brassica rapa	62.21	3.00e-118	418.00
IUUC-Cel-018424	Caenorhabditis elegans	66.29	8.00e-122	429.00
IUUC-Cja-019825	Callithrix jacchus	83.39	8.00e-124	436.00
IUUC-Cfa-021160	Canis familiaris	78.77	6.00e-163	566.00
IUUC-Cpo-022255	Cavia porcellus	79.95	1.00e-165	575.00
IUUC-Csa-023827	Chlorocebus sabaeus	78.97	3.00e-170	591.00
IUUC-Cho-025078	Choloepus hoffmanni	78.86	1.00e-155	542.00
IUUC-Cin-025217	Ciona intestinalis	71.46	5.00e-151	526.00
IUUC-Dre-027578	Danio rerio	80.30	1.00e-167	582.00
IUUC-Dno-029330	Dasypus novemcinctus	82.09	8.00e-163	566.00
IUUC-Dor-030425	Dipodomys ordii	69.23	6.00e-95	340.00
IUUC-Dme-031645	Drosophila melanogaster	61.31	2.00e-129	455.00
IUUC-Ete-032912	Echinops telfairi	89.58	5.00e-39	154.00
IUUC-Eca-033247	Equus caballus	83.88	4.00e-163	567.00
IUUC-Eeu-034472	Erinaceus europaeus	84.90	7.00e-158	549.00
IUUC-Fca-035684	Felis catus	83.47	1.00e-161	562.00
IUUC-Fal-037654	Ficedula albicollis	85.91	2.00e-162	565.00
IUUC-Gmo-039449	Gadus morhua	67.40	2.00e-128	451.00
IUUC-Gga-041051	Gallus gallus	85.52	5.00e-164	570.00
IUUC-Gac-042325	Gasterosteus aculeatus	79.55	3.00e-178	617.00
IUUC-Gma-043136	Glycine max	63.85	3.00e-118	418.00
IUUC-Ggo-044414	Gorilla gorilla	79.26	5.00e-165	573.00
IUUC-Hsa-046777	Homo sapiens	79.51	1.00e-167	582.00
IUUC-Hvu-047549	Hordeum vulgare	62.07	6.00e-94	337.00
IUUC-Itr-048175	Ictidomys tridecemlineatus	83.02	1.00e-163	568.00
IUUC-Lch-050142	Latimeria chalumnae	80.49	1.00e-178	618.00
IUUC-Lpe-050769	Leersia perrieri	65.71	4.00e-101	361.00
IUUC-Loc-052405	Lepisosteus oculatus	86.76	1.00e-159	555.00
IUUC-Laf-054152	Loxodonta africana	79.01	7.00e-163	566.00
IUUC-Mcc-055618	Macaca mulatta	84.14	2.00e-154	538.00
IUUC-Meu-056486	Macropus eugenii	87.54	5.00e-161	560.00
IUUC-Mtr-057871	Medicago truncatula	56.54	9.00e-121	426.00
IUUC-Mga-059284	Meleagris gallopavo	85.52	2.00e-163	568.00
IUUC-Mmr-061242	Microcebus murinus	82.54	3.00e-170	590.00
IUUC-Mdo-063034	Monodelphis domestica	84.51	1.00e-166	579.00
IUUC-Mmu-064322	Mus musculus	80.75	2.00e-161	561.00
IUUC-Mac-065128	Musa acuminata	61.74	8.00e-68	255.00
IUUC-Mpu-066438	Mustela putorius furo	83.33	7.00e-160	556.00
IUUC-Mlu-067578	Myotis lucifugus	84.43	1.00e-161	562.00
IUUC-Nle-069542	Nomascus leucogenys	83.20	2.00e-164	571.00
IUUC-Opr-070710	Ochotona princeps	79.50	9.00e-162	562.00
IUUC-Ont-072067	Oreochromis niloticus	85.87	1.00e-166	578.00
IUUC-Oan-073593	Ornithorhynchus anatinus	87.25	2.00e-168	584.00
IUUC-Ocu-073964	Oryctolagus cuniculus	77.53	5.00e-161	560.00
IUUC-Oba-075476	Oryza barthii	59.39	1.00e-114	405.00
IUUC-Obr-076517	Oryza brachyantha	59.50	8.00e-115	406.00
IUUC-Ogu-078664	Oryza glumaepatula	59.67	7.00e-115	407.00
IUUC-Olo-081012	Oryza longistaminata	59.39	2.00e-114	405.00
IUUC-Ome-081129	Oryza meridionalis	59.39	2.00e-114	405.00
IUUC-Oni-082265	Oryza nivara	60.50	1.00e-113	403.00
IUUC-Opu-084121	Oryza punctata	59.39	1.00e-114	405.00
IUUC-Oru-084451	Oryza rufipogon	57.42	5.00e-98	351.00
IUUC-Osa-086132	Oryza sativa	59.39	1.00e-114	405.00
IUUC-Ola-086842	Oryzias latipes	83.33	2.00e-162	565.00
IUUC-Oga-088160	Otolemur garnettii	84.82	5.00e-162	563.00
IUUC-Oar-089362	Ovis aries	83.61	4.00e-169	587.00
IUUC-Ptr-091256	Pan troglodytes	79.51	7.00e-168	583.00
IUUC-Pan-092913	Papio anubis	82.18	2.00e-161	561.00
IUUC-Psi-093740	Pelodiscus sinensis	90.40	5.00e-157	546.00
IUUC-Pma-094485	Petromyzon marinus	85.65	5.00e-109	386.00
IUUC-Ppa-095673	Physcomitrella patens	66.88	1.00e-112	399.00
IUUC-Pfo-096196	Poecilia formosa	85.05	1.00e-168	585.00
IUUC-Pab-098449	Pongo abelii	79.26	6.00e-168	583.00
IUUC-Pop-099049	Populus trichocarpa	57.21	1.00e-112	399.00
IUUC-Pca-100917	Procavia capensis	80.33	1.00e-101	363.00
IUUC-Ppe-101797	Prunus persica	61.54	2.00e-119	422.00
IUUC-Pva-102852	Pteropus vampyrus	83.74	8.00e-164	569.00
IUUC-Rno-105213	Rattus norvegicus	80.21	1.00e-160	559.00
IUUC-Sha-107569	Sarcophilus harrisii	79.36	9.00e-172	595.00
IUUC-Smo-109146	Selaginella moellendorffii	65.83	5.00e-112	397.00
IUUC-Sit-109794	Setaria italica	64.76	6.00e-113	400.00
IUUC-Sly-111622	Solanum lycopersicum	62.68	5.00e-116	410.00
IUUC-Stu-112522	Solanum tuberosum	64.20	1.00e-115	409.00
IUUC-Sar-113045	Sorex araneus	71.50	3.00e-147	514.00
IUUC-Sbi-113861	Sorghum bicolor	57.22	2.00e-112	398.00
IUUC-Ssc-115290	Sus scrofa	83.01	2.00e-136	478.00
IUUC-Tgu-117125	Taeniopygia guttata	86.65	2.00e-165	575.00
IUUC-Tru-118041	Takifugu rubripes	82.67	2.00e-167	581.00
IUUC-Tsy-119300	Tarsius syrichta	76.35	2.00e-130	457.00
IUUC-Tni-120310	Tetraodon nigroviridis	75.32	9.00e-158	549.00
IUUC-Tca-121405	Theobroma cacao	61.96	5.00e-115	407.00
IUUC-Tae-123656	Triticum aestivum	58.52	4.00e-113	401.00
IUUC-Tur-125985	Triticum urartu	60.88	1.00e-112	399.00
IUUC-Tbe-127478	Tupaia belangeri	77.14	4.00e-132	464.00
IUUC-Ttr-128169	Tursiops truncatus	82.59	6.00e-119	420.00
IUUC-Vpa-130508	Vicugna pacos	77.78	2.00e-134	471.00
IUUC-Vvi-131252	Vitis vinifera	59.56	7.00e-116	410.00
IUUC-Xma-133110	Xiphophorus maculatus	85.05	3.00e-172	597.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence