iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066146

Ensembl Protein ID

ENSMPUP00000013019.1

UniProt Accession

M3YNW2; M3YNW2_MUSPF

Genbank Protein ID

ENSMPUP00000013019

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01006127

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000013115.1	ENSMPUT00000013228.1	ENSMPUP00000013019.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	7.60e-145	484.0	962	1502

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++i+ed +++ll+l+++l+ a+R+++++++r+l++++++    
   Q: 962  PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDIAED-RRSLLHLSSRLNGALRQEQNFADRFLPDDEAA---- 1026
           689***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+++ea+ n+++++aa++++++++t+Ll++ve+++++       ++
   Q: 1027 ----QALGKTCWEALVSPLVQNITSPDEDGISPLgWLLDQYLECREAAHNPQSRAAAFSSRVRRLTHLLVHVEPCEAP-------PP 1102
           ....**************************************************************************.......** PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
            va +r k++++ +++++L++r+l+  ++++l++++ ++++eq++++lt++++++d   +V+r++e+++ lqk++se+F+++a+Fl 
   Q: 1103 AVAAPRPKGRNRSHDWSSLATRGLPssIVRNLTRCWGAVVEEQVNNFLTSHWRDDD---FVPRYCEHFHNLQKSSSELFGPRAAFLL 1186
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++  ++k ++lkaa+++E++Ar+iDq++++s ++g++++e++aql+++l+ + ++s++++   Fe+yY++++a+RLls  + 
   Q: 1187 ALHNGCAGGLLKLPFLKAAHVSEQFARHIDQRIQGSrIGGARGMEMLAQLQRCLETVLIFSGLEIattFEHYYQHYMADRLLS--VG 1271
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+++L ++M+++l++Se+l+rqF+                                            
   Q: 1272 SSWLEGAVLEQI----GPCFPNRLpQQMLRSLSTSEELQRQFHvyqlqrldqqllklddtekkiqggheasdkehkgekadgpgvaa 1354
           ************....*********************************************************************** PP
   S: 453  ..........eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqhtl 517
                     e+++ ++e +++e+svlvLs+++Wp a   +t  ++++LP++l+ t++++++fY        le++++R+LqW++ l
   Q: 1355 atgeedeeeeEDEDLYYEGAMPEVSVLVLSPRCWPIAsiRHTlnPRTCLPSYLRGTVNQYSNFYsqsqsypaLERGPQRQLQWTW-L 1440
           *******998888999*********************76333679****************************************.* PP
   S: 518  graelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kq 581
           grael++    g ++l+Vst+Qm++LL++n+ ++vsve+l + ++l+ ++L +++++L+ss+   +
   Q: 1441 GRAELQF----GDQTLHVSTVQMWLLLYLNDLKAVSVESLLALSGLSLDMLDQAIGPLTSSRgpLD 1502
           *******....*************************************************984433 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDD GDGGSSQVDC 60
KAEHILLWMS NDEIYANCHK MLGEDGQVIG PSQEIAGEAG ALDKSVLGEM ETDVKALIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCTGGAAA CGTGCATCGC AACAGTAGGC CGGGTATCCA ACGTCGATCA CAACAAACGT 60
GTCATCGGCA AGGCTGGGCG AAACCGCTGG CTGGGCAAGA GGCCTTCCAG TGGACTATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	93.86	0.00e+00	2977.00
IUUC-Bta-013285	Bos taurus	86.79	0.00e+00	2766.00
IUUC-Cja-019033	Callithrix jacchus	84.19	0.00e+00	2608.00
IUUC-Cfa-020695	Canis familiaris	92.40	0.00e+00	1793.00
IUUC-Cpo-021513	Cavia porcellus	79.49	0.00e+00	2479.00
IUUC-Csa-023798	Chlorocebus sabaeus	86.80	0.00e+00	2731.00
IUUC-Dor-030234	Dipodomys ordii	84.17	0.00e+00	2742.00
IUUC-Ete-032612	Echinops telfairi	77.65	0.00e+00	839.00
IUUC-Eca-033408	Equus caballus	91.50	0.00e+00	2802.00
IUUC-Fca-035483	Felis catus	91.80	0.00e+00	2900.00
IUUC-Gmo-038795	Gadus morhua	45.20	0.00e+00	1016.00
IUUC-Gac-041628	Gasterosteus aculeatus	46.56	0.00e+00	1308.00
IUUC-Ggo-044721	Gorilla gorilla	87.04	0.00e+00	2712.00
IUUC-Hsa-046406	Homo sapiens	87.16	0.00e+00	2750.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	88.27	0.00e+00	2726.00
IUUC-Lch-049956	Latimeria chalumnae	47.62	0.00e+00	858.00
IUUC-Laf-054068	Loxodonta africana	86.96	0.00e+00	2778.00
IUUC-Mcc-055464	Macaca mulatta	86.56	0.00e+00	2707.00
IUUC-Meu-056198	Macropus eugenii	56.10	0.00e+00	1589.00
IUUC-Mmr-061464	Microcebus murinus	86.74	0.00e+00	2710.00
IUUC-Mdo-062018	Monodelphis domestica	60.15	0.00e+00	1429.00
IUUC-Mmu-063413	Mus musculus	77.44	0.00e+00	2378.00
IUUC-Mlu-067036	Myotis lucifugus	87.20	0.00e+00	2798.00
IUUC-Opr-070670	Ochotona princeps	78.41	0.00e+00	2468.00
IUUC-Oan-073451	Ornithorhynchus anatinus	51.91	0.00e+00	1187.00
IUUC-Ocu-074155	Oryctolagus cuniculus	84.61	0.00e+00	2643.00
IUUC-Oga-089084	Otolemur garnettii	85.97	0.00e+00	2759.00
IUUC-Oar-090029	Ovis aries	88.58	0.00e+00	2792.00
IUUC-Ptr-091282	Pan troglodytes	85.61	0.00e+00	2730.00
IUUC-Pan-091883	Papio anubis	86.68	0.00e+00	2735.00
IUUC-Pab-098383	Pongo abelii	83.99	0.00e+00	2649.00
IUUC-Pca-100519	Procavia capensis	75.70	0.00e+00	837.00
IUUC-Pva-102417	Pteropus vampyrus	87.16	0.00e+00	2233.00
IUUC-Rno-105962	Rattus norvegicus	79.42	0.00e+00	2509.00
IUUC-Sar-113750	Sorex araneus	82.24	1.00e-176	614.00
IUUC-Ssc-115899	Sus scrofa	82.09	0.00e+00	2469.00
IUUC-Tsy-118860	Tarsius syrichta	83.22	0.00e+00	1101.00
IUUC-Tbe-127660	Tupaia belangeri	85.82	0.00e+00	1416.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence