iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020165

Ensembl Protein ID

ENSCAFP00000017792.3

UniProt Accession

E2RSN0; E2RSN0_CANLF

Genbank Protein ID

ENSCAFP00000017792

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAEX03001707

Gene Name

FGR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000012070.3	ENSCAFT00000019186.3	ENSCAFP00000017792.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.90e-16	58.5	79	135

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++lydyea ++d+Lt++kG++ +++  ++++++W+++ +  +g+ G +P+n+v+ ++
   Q: 79   LFIALYDYEARTEDDLTFTKGEKFHIL--NNTEGDWWEARSLSSGRTGYIPSNYVAPVD 135
           5789***********************..8999**********************9987 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MGCVFCKKSE PGLKDDVGLE GEFRGSGAAD RYGPDPTQAR GVSSFAHIPN YNNFPTQSTN 60
PTFLDGGTIR GISGTGVTLF IALYDYEART EDDLTFTKGE KFHILNNTEG DWWEARSLSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTATTTTAGG GCTCTTACCA CAGCCTGCTT CACAGTTCGC CAGATGGGTG TCACCCCCCC 60
CATACACATG GGAGAACAGT TACAGTGAAG AGTGAGAGGG GCTGGTGGGT CTAGAGGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016235--C:aggresome
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0050830--P:defense response to Gram-positive bacterium
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0030335--P:positive regulation of cell migration
GO:0050715--P:positive regulation of cytokine secretion
GO:0043306--P:positive regulation of mast cell degranulation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0045088--P:regulation of innate immune response
GO:0050764--P:regulation of phagocytosis
GO:0045859--P:regulation of protein kinase activity
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

cfa:487341

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001938	Ailuropoda melanoleuca	94.50	0.00e+00	1043.00
IUUC-Bta-012607	Bos taurus	90.13	0.00e+00	997.00
IUUC-Cja-018914	Callithrix jacchus	85.93	0.00e+00	947.00
IUUC-Cpo-021476	Cavia porcellus	88.43	0.00e+00	959.00
IUUC-Csa-023692	Chlorocebus sabaeus	88.85	0.00e+00	989.00
IUUC-Dno-028920	Dasypus novemcinctus	89.37	0.00e+00	980.00
IUUC-Eca-033581	Equus caballus	91.84	0.00e+00	1016.00
IUUC-Fca-036499	Felis catus	92.60	0.00e+00	1030.00
IUUC-Ggo-044640	Gorilla gorilla	89.22	0.00e+00	991.00
IUUC-Hsa-046751	Homo sapiens	89.04	0.00e+00	988.00
IUUC-Itr-048218	Ictidomys tridecemlineatus	89.94	0.00e+00	989.00
IUUC-Laf-054128	Loxodonta africana	89.18	0.00e+00	994.00
IUUC-Mcc-054715	Macaca mulatta	89.04	0.00e+00	993.00
IUUC-Meu-056155	Macropus eugenii	81.64	0.00e+00	769.00
IUUC-Mmr-060615	Microcebus murinus	90.40	0.00e+00	989.00
IUUC-Mmu-063286	Mus musculus	84.63	0.00e+00	937.00
IUUC-Mpu-066641	Mustela putorius furo	93.93	0.00e+00	1038.00
IUUC-Oan-073486	Ornithorhynchus anatinus	77.34	0.00e+00	853.00
IUUC-Ocu-074552	Oryctolagus cuniculus	90.87	0.00e+00	979.00
IUUC-Oga-088731	Otolemur garnettii	90.70	0.00e+00	1008.00
IUUC-Oar-090207	Ovis aries	90.51	0.00e+00	998.00
IUUC-Ptr-090979	Pan troglodytes	89.04	0.00e+00	989.00
IUUC-Pan-092188	Papio anubis	89.22	0.00e+00	993.00
IUUC-Pab-098617	Pongo abelii	88.66	0.00e+00	988.00
IUUC-Pca-100834	Procavia capensis	79.89	0.00e+00	845.00
IUUC-Rno-104945	Rattus norvegicus	84.44	0.00e+00	925.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence