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Tag Content
iUUCD ID IUUC-Ago-007898
Ensembl Protein ID AAS53075
UniProt Accession Q755X2; ATG8_ASHGO
Genbank Protein ID AAS53075.1
Protein Name Autophagy-related protein 8; Autophagy-related ubiquitin-like modifier ATG8
Genbank Nucleotide ID AE016818
Gene Name ATG8; AER396W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AGOS_AER396W AAS53075 AAS53075
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG8 54.46 4.00e-33 136.00 IUUC-Hsa-045905
ULD/UBL/ATG8 86.84 2.00e-56 211.00 IUUC-Sce-106150
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Ashbya gossypii
Functional Description
(View)

Functional Description



     Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
Protein Sequence
(Fasta)
MSSFKSEYPF EKRKAESERI CSQFENRVPV ICERAEKSDI PEVDRRKYLV PADLTVGQFV 60
YVIRRRIKLP AEKAIFIFVN DTLPPTAALM FAVYQEHKDK DGFLYVKYSG ENTFGSEENQ 120
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Protein Fasta Sequence



>IUUC-Ago-007898|ULD,ATG8|Ashbya gossypii
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Nucleotide Sequence
(Fasta)
ATGTCGTCGT TTAAGTCCGA GTACCCTTTT GAAAAGCGCA AAGCAGAGTC GGAGCGTATT 60
TGTTCGCAGT TTGAGAACCG CGTGCCGGTA ATCTGTGAGC GTGCAGAGAA GTCTGATATC 120
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Nucleotide Fasta Sequence



>IUUC-Ago-007898|ULD,ATG8|Ashbya gossypii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0926--Vacuole

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0019898--C:extrinsic component of membrane
GO:0000329--C:fungal-type vacuole membrane
GO:0005634--C:nucleus
GO:0000407--C:pre-autophagosomal structure
GO:0031386--F:protein tag
GO:0000045--P:autophagosome assembly
GO:0034629--P:cellular protein complex localization
GO:0032258--P:CVT pathway
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0044805--P:late nucleophagy
GO:0061025--P:membrane fusion
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0061709--P:reticulophagy

KEGG ago:AGOS_AER396W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000059 Aegilops tauschii 68.70 2.00e-47 178.00
IUUC-Aml-001323 Ailuropoda melanoleuca 54.46 6.00e-35 136.00
IUUC-Atr-002791 Amborella trichopoda 70.43 4.00e-48 180.00
IUUC-Apl-003994 Anas platyrhynchos 52.21 2.00e-33 132.00
IUUC-Aca-005288 Anolis carolinensis 53.10 5.00e-35 137.00
IUUC-Aly-005987 Arabidopsis lyrata 70.43 6.00e-48 179.00
IUUC-Ath-007295 Arabidopsis thaliana 69.30 2.00e-42 162.00
IUUC-Acl-008314 Aspergillus clavatus 72.81 2.00e-48 181.00
IUUC-Afl-008708 Aspergillus flavus 72.81 1.00e-48 182.00
IUUC-Afu-009097 Aspergillus fumigatus 72.81 2.00e-48 181.00
IUUC-Ani-009196 Aspergillus nidulans 72.81 1.00e-48 182.00
IUUC-Ang-009530 Aspergillus niger 72.81 2.00e-48 181.00
IUUC-Aor-009909 Aspergillus oryzae 72.81 1.00e-48 182.00
IUUC-Ate-010358 Aspergillus terreus 72.81 2.00e-48 181.00
IUUC-Ame-010914 Astyanax mexicanus 53.98 6.00e-35 136.00
IUUC-Bgr-012248 Blumeria graminis 73.04 6.00e-49 183.00
IUUC-Bta-012805 Bos taurus 54.46 6.00e-35 136.00
IUUC-Bci-013959 Botrytis cinerea 71.93 2.00e-48 182.00
IUUC-Bdi-014390 Brachypodium distachyon 71.93 5.00e-48 180.00
IUUC-Bol-015957 Brassica oleracea 70.43 4.00e-47 177.00
IUUC-Bra-016921 Brassica rapa 70.43 4.00e-48 180.00
IUUC-Cel-018200 Caenorhabditis elegans 48.70 1.00e-31 126.00
IUUC-Cja-019273 Callithrix jacchus 54.46 2.00e-35 138.00
IUUC-Cfa-020603 Canis familiaris 54.46 6.00e-35 136.00
IUUC-Cpo-021831 Cavia porcellus 53.57 8.00e-35 136.00
IUUC-Cre-022866 Chlamydomonas reinhardtii 65.81 6.00e-41 157.00
IUUC-Csa-024117 Chlorocebus sabaeus 54.46 6.00e-35 136.00
IUUC-Cho-025008 Choloepus hoffmanni 49.56 4.00e-31 124.00
IUUC-Cin-025297 Ciona intestinalis 50.00 7.00e-33 129.00
IUUC-Csv-026146 Ciona savignyi 34.21 1.00e-17 79.30
IUUC-Cgl-026691 Colletotrichum gloeosporioides 51.85 6.00e-42 160.00
IUUC-Cne-026889 Cryptococcus neoformans 72.03 2.00e-49 185.00
IUUC-Dre-028351 Danio rerio 54.46 1.00e-34 136.00
IUUC-Dno-029331 Dasypus novemcinctus 53.57 6.00e-35 136.00
IUUC-Dor-030245 Dipodomys ordii 54.46 6.00e-35 136.00
IUUC-Dse-031428 Dothistroma septosporum 72.81 9.00e-49 182.00
IUUC-Dme-031813 Drosophila melanogaster 53.10 3.00e-34 134.00
IUUC-Ete-032671 Echinops telfairi 54.46 5.00e-35 137.00
IUUC-Eca-034113 Equus caballus 53.57 1.00e-34 136.00
IUUC-Eeu-035131 Erinaceus europaeus 53.49 1.00e-25 104.00
IUUC-Fca-036493 Felis catus 54.46 1.00e-34 136.00
IUUC-Fal-036896 Ficedula albicollis 53.57 1.00e-34 135.00
IUUC-Fox-037846 Fusarium oxysporum 72.81 9.00e-49 182.00
IUUC-Fso-038134 Fusarium solani 72.81 1.00e-48 182.00
IUUC-Gmo-039671 Gadus morhua 53.04 7.00e-35 136.00
IUUC-Ggr-039770 Gaeumannomyces graminis 73.68 7.00e-49 183.00
IUUC-Gga-040257 Gallus gallus 53.98 1.00e-34 135.00
IUUC-Gac-041604 Gasterosteus aculeatus 54.46 1.00e-35 139.00
IUUC-Gma-044081 Glycine max 68.10 3.00e-48 181.00
IUUC-Ggo-044860 Gorilla gorilla 54.46 9.00e-35 136.00
IUUC-Hsa-045905 Homo sapiens 54.46 6.00e-35 136.00
IUUC-Hvu-047588 Hordeum vulgare 70.34 2.00e-48 181.00
IUUC-Itr-048405 Ictidomys tridecemlineatus 54.46 6.00e-35 136.00
IUUC-Kpa-049124 Komagataella pastoris 76.52 3.00e-50 187.00
IUUC-Lch-049542 Latimeria chalumnae 52.68 7.00e-35 136.00
IUUC-Lpe-050787 Leersia perrieri 67.83 4.00e-47 177.00
IUUC-Loc-052290 Lepisosteus oculatus 53.98 6.00e-35 137.00
IUUC-Laf-054203 Loxodonta africana 54.46 6.00e-35 136.00
IUUC-Mcc-055307 Macaca mulatta 54.46 6.00e-35 136.00
IUUC-Meu-056515 Macropus eugenii 53.57 8.00e-35 136.00
IUUC-Mor-057276 Magnaporthe oryzae 73.68 7.00e-49 183.00
IUUC-Mpo-057469 Magnaporthe poae 73.68 1.00e-48 182.00
IUUC-Mtr-057664 Medicago truncatula 69.30 1.00e-42 162.00
IUUC-Mla-059098 Melampsora laricipopulina 71.55 2.00e-49 184.00
IUUC-Mga-060108 Meleagris gallopavo 51.75 2.00e-33 131.00
IUUC-Mvi-060496 Microbotryum violaceum 72.17 2.00e-48 181.00
IUUC-Mmr-061776 Microcebus murinus 54.46 6.00e-35 136.00
IUUC-Mdo-061915 Monodelphis domestica 53.57 9.00e-35 136.00
IUUC-Mmu-064157 Mus musculus 54.46 6.00e-35 136.00
IUUC-Mac-064739 Musa acuminata 69.57 5.00e-43 163.00
IUUC-Mpu-066760 Mustela putorius furo 53.57 7.00e-35 136.00
IUUC-Mlu-067166 Myotis lucifugus 54.46 6.00e-35 136.00
IUUC-Nfi-068367 Neosartorya fischeri 72.81 2.00e-48 181.00
IUUC-Ncr-068894 Neurospora crassa 71.19 8.00e-49 182.00
IUUC-Nle-069220 Nomascus leucogenys 54.46 6.00e-35 136.00
IUUC-Opr-070777 Ochotona princeps 54.46 6.00e-35 136.00
IUUC-Ont-072343 Oreochromis niloticus 53.57 1.00e-34 135.00
IUUC-Oan-073485 Ornithorhynchus anatinus 55.24 4.00e-33 130.00
IUUC-Ocu-074148 Oryctolagus cuniculus 54.46 6.00e-35 136.00
IUUC-Oba-075926 Oryza barthii 71.05 1.00e-47 178.00
IUUC-Obr-076374 Oryza brachyantha 71.05 1.00e-47 178.00
IUUC-Ogl-077457 Oryza glaberrima 71.05 1.00e-47 178.00
IUUC-Ogu-078078 Oryza glumaepatula 71.05 1.00e-47 178.00
IUUC-Oin-079771 Oryza indica 71.05 1.00e-47 178.00
IUUC-Olo-080412 Oryza longistaminata 71.05 1.00e-47 178.00
IUUC-Ome-081791 Oryza meridionalis 71.05 1.00e-47 178.00
IUUC-Oni-082774 Oryza nivara 71.05 1.00e-47 178.00
IUUC-Opu-083486 Oryza punctata 71.05 5.00e-47 179.00
IUUC-Oru-084197 Oryza rufipogon 67.83 5.00e-47 177.00
IUUC-Osa-085439 Oryza sativa 71.05 1.00e-47 178.00
IUUC-Ola-086310 Oryzias latipes 53.98 7.00e-35 136.00
IUUC-Olu-087892 Ostreococcus lucimarinus 75.65 8.00e-50 186.00
IUUC-Oga-088312 Otolemur garnettii 54.46 6.00e-35 136.00
IUUC-Oar-089989 Ovis aries 54.46 6.00e-35 136.00
IUUC-Ptr-091108 Pan troglodytes 54.46 6.00e-35 136.00
IUUC-Pan-092269 Papio anubis 53.57 8.00e-35 136.00
IUUC-Psi-093055 Pelodiscus sinensis 52.21 2.00e-33 132.00
IUUC-Pma-094337 Petromyzon marinus 52.68 4.00e-36 140.00
IUUC-Pno-095035 Phaeosphaeria nodorum 72.81 1.00e-48 182.00
IUUC-Ppa-095786 Physcomitrella patens 69.57 4.00e-47 177.00
IUUC-Pfo-096380 Poecilia formosa 53.57 1.00e-34 135.00
IUUC-Pab-097660 Pongo abelii 54.46 6.00e-35 136.00
IUUC-Pop-098791 Populus trichocarpa 69.30 1.00e-46 175.00
IUUC-Pca-100230 Procavia capensis 54.46 6.00e-35 136.00
IUUC-Ppe-101670 Prunus persica 69.30 3.00e-42 160.00
IUUC-Pva-103103 Pteropus vampyrus 52.21 2.00e-33 132.00
IUUC-Pte-104230 Pyrenophora teres 72.81 1.00e-48 182.00
IUUC-Rno-105497 Rattus norvegicus 54.46 6.00e-35 136.00
IUUC-Sce-106150 Saccharomyces cerevisiae 86.84 2.00e-57 211.00
IUUC-Sha-106656 Sarcophilus harrisii 54.46 6.00e-35 136.00
IUUC-Sja-107857 Schizosaccharomyces japonicus 68.10 1.00e-45 172.00
IUUC-Spo-108156 Schizosaccharomyces pombe 66.09 9.00e-39 149.00
IUUC-Ssl-108578 Sclerotinia sclerotiorum 71.93 1.00e-48 182.00
IUUC-Smo-109082 Selaginella moellendorffii 72.81 7.00e-48 179.00
IUUC-Sit-110531 Setaria italica 71.05 6.00e-48 180.00
IUUC-Sly-111488 Solanum lycopersicum 70.43 1.00e-43 165.00
IUUC-Stu-112559 Solanum tuberosum 70.43 1.00e-43 165.00
IUUC-Sar-113670 Sorex araneus 49.11 1.00e-30 122.00
IUUC-Sbi-114346 Sorghum bicolor 71.05 1.00e-47 178.00
IUUC-Sre-114964 Sporisorium reilianum 71.05 1.00e-47 179.00
IUUC-Ssc-116182 Sus scrofa 54.46 6.00e-35 136.00
IUUC-Tgu-117195 Taeniopygia guttata 53.57 1.00e-34 135.00
IUUC-Tru-118632 Takifugu rubripes 52.99 7.00e-36 140.00
IUUC-Tsy-118919 Tarsius syrichta 52.21 2.00e-33 132.00
IUUC-Tni-120706 Tetraodon nigroviridis 53.51 2.00e-34 135.00
IUUC-Tca-121537 Theobroma cacao 70.18 2.00e-47 178.00
IUUC-Tre-122077 Trichoderma reesei 72.17 5.00e-49 183.00
IUUC-Tvi-122400 Trichoderma virens 72.17 5.00e-49 183.00
IUUC-Tae-123593 Triticum aestivum 71.05 1.00e-47 179.00
IUUC-Tur-126158 Triticum urartu 68.70 3.00e-47 177.00
IUUC-Tme-126955 Tuber melanosporum 71.79 6.00e-48 181.00
IUUC-Tbe-127765 Tupaia belangeri 58.14 3.00e-29 117.00
IUUC-Ttr-128205 Tursiops truncatus 53.57 8.00e-35 136.00
IUUC-Uma-129435 Ustilago maydis 71.05 1.00e-47 179.00
IUUC-Vda-129807 Verticillium dahliae 71.19 1.00e-48 182.00
IUUC-Vpa-130804 Vicugna pacos 53.57 7.00e-35 136.00
IUUC-Vvi-130830 Vitis vinifera 70.43 8.00e-43 162.00
IUUC-Xtr-132685 Xenopus tropicalis 53.57 5.00e-35 137.00
IUUC-Xma-133400 Xiphophorus maculatus 52.99 1.00e-35 139.00
IUUC-Yli-134327 Yarrowia lipolytica 72.88 2.00e-44 168.00
IUUC-Zma-135270 Zea mays 71.93 4.00e-48 180.00
Created Date 25-Jun-2017

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