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Tag Content
UUCD2 ID IUUC-Aml-002124
UUCD1 version UUC-AiM-00808
Ensembl Protein ID ENSAMEP00000016226.1
UniProt Accession G1MA53; G1MA53_AILME
Genbank Protein ID ENSAMEP00000016226
Protein Name E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8
Genbank Nucleotide ID ACTA01043896
Gene Name RNF8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMEG00000015391.1 ENSAMET00000016900.1 ENSAMEP00000016226.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 2.70e-07 31.1 405 443
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       +++  CP+Cr
   Q: 405  CIICSEYFIE-AVTLNCAHSFCSYCINEW------MKRKVECPICR 443
           ********99.899***************......**********8 PP
   
Organism Ailuropoda melanoleuca
Protein Sequence
(Fasta)
MEEPGLLVTG DRARGRSWCL RRVGMNAEWL VLEEGNEVTI GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNV QGQWTIMDNK SLNGVWLNRE RLEPLKVYSI HKGDHIQLGV PLENKEKAEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Aml-002124|E3,RING|Ailuropoda melanoleuca
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGGAGC CCGGCTTGTT GGTCACGGGA GACCGCGCCC GTGGCCGGAG CTGGTGCTTG 60
CGGCGGGTAG GGATGAACGC CGAGTGGCTG GTGCTGGAGG AAGGAAACGA GGTGAGGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Aml-002124|E3,RING|Ailuropoda melanoleuca
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00498--FHA
PF00097--zf-C3HC4
SMART

SM00240--FHA
SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003664 Anas platyrhynchos 80.68 5.00e-39 152.00
IUUC-Aca-005036 Anolis carolinensis 56.96 6.00e-110 390.00
IUUC-Ame-011537 Astyanax mexicanus 41.27 7.00e-85 307.00
IUUC-Bta-013297 Bos taurus 86.13 0.00e+00 660.00
IUUC-Cja-019201 Callithrix jacchus 80.62 0.00e+00 653.00
IUUC-Cfa-021041 Canis familiaris 90.48 0.00e+00 755.00
IUUC-Csa-024133 Chlorocebus sabaeus 83.64 0.00e+00 704.00
IUUC-Cho-024624 Choloepus hoffmanni 79.35 3.00e-141 494.00
IUUC-Dre-027918 Danio rerio 57.50 4.00e-49 189.00
IUUC-Dno-029774 Dasypus novemcinctus 84.68 0.00e+00 704.00
IUUC-Dor-030190 Dipodomys ordii 73.72 1.00e-152 532.00
IUUC-Ete-032301 Echinops telfairi 66.67 1.00e-140 493.00
IUUC-Eca-033607 Equus caballus 88.14 0.00e+00 632.00
IUUC-Eeu-034888 Erinaceus europaeus 82.18 2.00e-124 438.00
IUUC-Fca-036075 Felis catus 88.61 0.00e+00 757.00
IUUC-Fal-037569 Ficedula albicollis 61.50 2.00e-109 389.00
IUUC-Gmo-038588 Gadus morhua 40.00 1.00e-71 263.00
IUUC-Gga-040777 Gallus gallus 58.69 3.00e-118 418.00
IUUC-Gac-042463 Gasterosteus aculeatus 41.51 7.00e-61 228.00
IUUC-Ggo-045269 Gorilla gorilla 84.27 0.00e+00 715.00
IUUC-Hsa-046249 Homo sapiens 83.85 0.00e+00 694.00
IUUC-Itr-048314 Ictidomys tridecemlineatus 85.48 0.00e+00 715.00
IUUC-Kpa-049392 Komagataella pastoris 38.46 3.00e-08 52.40
IUUC-Lch-049805 Latimeria chalumnae 51.91 5.00e-112 398.00
IUUC-Loc-052377 Lepisosteus oculatus 50.11 9.00e-93 333.00
IUUC-Mcc-055344 Macaca mulatta 83.85 0.00e+00 712.00
IUUC-Meu-055950 Macropus eugenii 62.31 7.00e-126 443.00
IUUC-Mla-059052 Melampsora laricipopulina 36.92 3.00e-10 58.20
IUUC-Mga-060049 Meleagris gallopavo 57.23 3.00e-115 408.00
IUUC-Mmr-061431 Microcebus murinus 85.71 0.00e+00 673.00
IUUC-Mdo-062016 Monodelphis domestica 68.11 1.00e-122 435.00
IUUC-Mmu-063235 Mus musculus 73.76 0.00e+00 637.00
IUUC-Mpu-066449 Mustela putorius furo 94.00 0.00e+00 810.00
IUUC-Mlu-067588 Myotis lucifugus 81.78 0.00e+00 647.00
IUUC-Nle-069192 Nomascus leucogenys 84.47 0.00e+00 714.00
IUUC-Opr-070300 Ochotona princeps 64.80 8.00e-146 510.00
IUUC-Ont-071998 Oreochromis niloticus 42.64 6.00e-64 238.00
IUUC-Oan-073610 Ornithorhynchus anatinus 66.67 2.00e-66 244.00
IUUC-Ocu-074603 Oryctolagus cuniculus 79.92 0.00e+00 649.00
IUUC-Ola-086681 Oryzias latipes 40.55 1.00e-73 270.00
IUUC-Oga-088183 Otolemur garnettii 86.54 0.00e+00 724.00
IUUC-Oar-090255 Ovis aries 86.32 7.00e-174 603.00
IUUC-Ptr-091029 Pan troglodytes 83.30 0.00e+00 650.00
IUUC-Pan-092241 Papio anubis 83.64 0.00e+00 711.00
IUUC-Psi-093506 Pelodiscus sinensis 61.86 6.00e-131 460.00
IUUC-Pma-094579 Petromyzon marinus 56.67 1.00e-26 114.00
IUUC-Pfo-097014 Poecilia formosa 42.86 2.00e-62 233.00
IUUC-Pab-098530 Pongo abelii 83.22 0.00e+00 657.00
IUUC-Pca-100939 Procavia capensis 63.98 5.00e-148 517.00
IUUC-Pva-103148 Pteropus vampyrus 81.16 0.00e+00 669.00
IUUC-Rno-105338 Rattus norvegicus 75.36 0.00e+00 660.00
IUUC-Sce-106282 Saccharomyces cerevisiae 37.08 6.00e-07 48.50
IUUC-Sha-107187 Sarcophilus harrisii 66.34 8.00e-103 367.00
IUUC-Sar-113356 Sorex araneus 68.73 6.00e-127 447.00
IUUC-Ssc-116290 Sus scrofa 87.34 0.00e+00 751.00
IUUC-Tru-117910 Takifugu rubripes 40.86 7.00e-62 231.00
IUUC-Tsy-119329 Tarsius syrichta 80.27 1.00e-168 585.00
IUUC-Tni-120521 Tetraodon nigroviridis 40.09 2.00e-62 233.00
IUUC-Tme-126989 Tuber melanosporum 32.76 9.00e-07 48.90
IUUC-Ttr-128997 Tursiops truncatus 80.72 0.00e+00 650.00
IUUC-Vpa-130154 Vicugna pacos 84.02 0.00e+00 723.00
IUUC-Xtr-132805 Xenopus tropicalis 51.14 3.00e-103 368.00
IUUC-Xma-133620 Xiphophorus maculatus 42.83 2.00e-62 233.00
Created Date 25-Jun-2017

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