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Tag Content
UUCD2 ID IUUC-Cja-019201
UUCD1 version UUC-CaJ-00239
Ensembl Protein ID ENSCJAP00000010149.2
UniProt Accession F6YBI1; F6YBI1_CALJA
Genbank Protein ID ENSCJAP00000010149
Protein Name E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8
Genbank Nucleotide ID ACFV01108908
Gene Name RNF8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCJAG00000005529.2 ENSCJAT00000010709.2 ENSCJAP00000010134.2
ENSCJAG00000005529.2 ENSCJAT00000010727.2 ENSCJAP00000010149.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.80e-06 29.3 404 442
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C+  w       ++++ CP+Cr
   Q: 404  CIICSEYFIE-AVTLNCAHSFCSYCISEW------MKRKIECPICR 442
           ********99.899***************......**********8 PP
   
Organism Callithrix jacchus
Protein Sequence
(Fasta)
QYQPGMFYLC VTLRSRNECL LFLGXSAGWL LLEDGCEVTV GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNH EGQWTITDNK SLNGVWLNRE RLEPLRVYSI HKGDYIQLGV PLENKENAEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cja-019201|E3,RING|Callithrix jacchus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAATACCAAC CTGGAATGTT TTATCTGTGT GTCACTCTCA GATCAAGAAA TGAGAAATGC 60
CAGGTGATCA AGATGAACAC CAACAGTGAT AATTCATGTT GATAGCCTGT ACCCTTGATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cja-019201|E3,RING|Callithrix jacchus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00498--FHA
SMART

SM00240--FHA
SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002124 Ailuropoda melanoleuca 81.88 0.00e+00 627.00
IUUC-Apl-003664 Anas platyrhynchos 78.41 6.00e-38 149.00
IUUC-Aca-005036 Anolis carolinensis 58.35 2.00e-118 419.00
IUUC-Ame-011537 Astyanax mexicanus 43.47 4.00e-87 315.00
IUUC-Bta-013297 Bos taurus 83.94 6.00e-172 597.00
IUUC-Cel-018658 Caenorhabditis elegans 41.07 2.00e-07 50.80
IUUC-Cfa-021041 Canis familiaris 81.69 0.00e+00 659.00
IUUC-Cpo-021431 Cavia porcellus 36.92 4.00e-08 53.50
IUUC-Csa-024133 Chlorocebus sabaeus 89.42 0.00e+00 751.00
IUUC-Cho-024624 Choloepus hoffmanni 75.37 4.00e-135 474.00
IUUC-Dre-027918 Danio rerio 42.16 3.00e-80 292.00
IUUC-Dno-029774 Dasypus novemcinctus 82.51 0.00e+00 651.00
IUUC-Dor-030190 Dipodomys ordii 73.86 4.00e-145 508.00
IUUC-Ete-032301 Echinops telfairi 74.88 8.00e-138 483.00
IUUC-Eca-033607 Equus caballus 85.84 2.00e-172 598.00
IUUC-Eeu-034888 Erinaceus europaeus 80.20 1.00e-117 416.00
IUUC-Fca-036075 Felis catus 81.88 0.00e+00 669.00
IUUC-Fal-037569 Ficedula albicollis 61.18 8.00e-116 410.00
IUUC-Gmo-038588 Gadus morhua 41.36 1.00e-74 273.00
IUUC-Gga-040777 Gallus gallus 58.48 2.00e-115 409.00
IUUC-Gac-042463 Gasterosteus aculeatus 41.08 7.00e-65 241.00
IUUC-Ggo-045269 Gorilla gorilla 90.04 0.00e+00 764.00
IUUC-Hsa-046249 Homo sapiens 89.42 0.00e+00 736.00
IUUC-Itr-048314 Ictidomys tridecemlineatus 84.19 0.00e+00 656.00
IUUC-Lch-049805 Latimeria chalumnae 51.28 2.00e-112 399.00
IUUC-Loc-052377 Lepisosteus oculatus 49.25 2.00e-89 322.00
IUUC-Laf-053663 Loxodonta africana 42.25 4.00e-09 56.60
IUUC-Mcc-055344 Macaca mulatta 89.83 0.00e+00 761.00
IUUC-Meu-055950 Macropus eugenii 62.45 3.00e-125 441.00
IUUC-Mla-059052 Melampsora laricipopulina 36.92 1.00e-09 56.60
IUUC-Mga-060049 Meleagris gallopavo 58.89 6.00e-116 410.00
IUUC-Mmr-061431 Microcebus murinus 82.71 4.00e-178 617.00
IUUC-Mdo-062016 Monodelphis domestica 67.33 6.00e-125 442.00
IUUC-Mmu-063235 Mus musculus 71.10 5.00e-168 583.00
IUUC-Mpu-066449 Mustela putorius furo 84.79 0.00e+00 699.00
IUUC-Mlu-067588 Myotis lucifugus 79.19 2.00e-170 592.00
IUUC-Nle-069192 Nomascus leucogenys 90.25 0.00e+00 766.00
IUUC-Opr-070300 Ochotona princeps 62.32 2.00e-133 468.00
IUUC-Ont-071998 Oreochromis niloticus 41.33 2.00e-65 243.00
IUUC-Oan-073610 Ornithorhynchus anatinus 66.23 2.00e-66 244.00
IUUC-Ocu-074603 Oryctolagus cuniculus 77.57 7.00e-175 606.00
IUUC-Ola-086681 Oryzias latipes 40.30 1.00e-72 266.00
IUUC-Oga-088183 Otolemur garnettii 83.30 0.00e+00 672.00
IUUC-Oar-090255 Ovis aries 84.22 1.00e-164 572.00
IUUC-Ptr-091029 Pan troglodytes 90.79 0.00e+00 719.00
IUUC-Pan-092241 Papio anubis 89.63 0.00e+00 758.00
IUUC-Psi-093506 Pelodiscus sinensis 64.19 1.00e-131 462.00
IUUC-Pma-094579 Petromyzon marinus 56.67 2.00e-26 113.00
IUUC-Pfo-097014 Poecilia formosa 42.22 1.00e-65 243.00
IUUC-Pab-098530 Pongo abelii 91.72 0.00e+00 739.00
IUUC-Pca-100939 Procavia capensis 61.54 5.00e-132 464.00
IUUC-Pva-103148 Pteropus vampyrus 76.75 2.00e-176 612.00
IUUC-Rno-105338 Rattus norvegicus 73.31 2.00e-177 615.00
IUUC-Sce-106282 Saccharomyces cerevisiae 33.71 1.00e-06 47.80
IUUC-Sha-107187 Sarcophilus harrisii 66.75 9.00e-105 373.00
IUUC-Sar-113356 Sorex araneus 66.42 2.00e-131 461.00
IUUC-Ssc-116290 Sus scrofa 82.57 0.00e+00 711.00
IUUC-Tgu-117207 Taeniopygia guttata 40.62 6.00e-09 55.80
IUUC-Tru-117910 Takifugu rubripes 40.94 5.00e-63 234.00
IUUC-Tsy-119329 Tarsius syrichta 79.56 1.00e-166 579.00
IUUC-Tni-120521 Tetraodon nigroviridis 39.40 2.00e-62 233.00
IUUC-Tme-126989 Tuber melanosporum 32.20 9.00e-07 48.50
IUUC-Ttr-128997 Tursiops truncatus 79.82 2.00e-179 622.00
IUUC-Vpa-130154 Vicugna pacos 81.84 0.00e+00 657.00
IUUC-Xtr-132805 Xenopus tropicalis 49.90 3.00e-103 369.00
IUUC-Xma-133620 Xiphophorus maculatus 42.83 6.00e-66 244.00
Created Date 25-Jun-2017

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