iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088183

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8

Genbank Nucleotide ID

AAQR03060723

Gene Name

RNF8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000015984.2	ENSOGAT00000015986.2	ENSOGAP00000014311.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.30e-07	32.0	402	440

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       ++++ CP+Cr
   Q: 402  CIICSEYFIE-AVTLNCAHSFCSYCINEW------MKRKIECPICR 440
           ********99.899***************......**********8 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MGEPDFLVTG DCVGGRSWCL RRVGMNAEWL LLEDGREVTV GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNP EGQWTIMDNK SLNGVWLNRE RLEPLKVYSI HKGDHIQLGV PLENKENAEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGAGC CAGACTTCTT GGTCACGGGA GACTGTGTCG GTGGCCGGAG CTGGTGCTTG 60
CGGCGGGTGG GGATGAACGC CGAGTGGCTG CTGCTGGAGG ATGGGCGAGA GGTGAGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	86.54	0.00e+00	667.00
IUUC-Apl-003664	Anas platyrhynchos	77.27	2.00e-37	147.00
IUUC-Aca-005036	Anolis carolinensis	58.02	3.00e-119	421.00
IUUC-Ame-011537	Astyanax mexicanus	42.50	1.00e-87	317.00
IUUC-Bta-013297	Bos taurus	85.80	0.00e+00	639.00
IUUC-Cja-019201	Callithrix jacchus	83.30	0.00e+00	645.00
IUUC-Cfa-021041	Canis familiaris	87.24	0.00e+00	707.00
IUUC-Csa-024133	Chlorocebus sabaeus	85.98	0.00e+00	722.00
IUUC-Cho-024624	Choloepus hoffmanni	77.36	5.00e-135	473.00
IUUC-Dre-027918	Danio rerio	42.04	1.00e-83	303.00
IUUC-Dno-029774	Dasypus novemcinctus	85.39	0.00e+00	689.00
IUUC-Dor-030190	Dipodomys ordii	73.50	7.00e-149	520.00
IUUC-Ete-032301	Echinops telfairi	67.08	5.00e-141	494.00
IUUC-Eca-033607	Equus caballus	87.11	9.00e-175	606.00
IUUC-Eeu-034888	Erinaceus europaeus	82.39	7.00e-123	434.00
IUUC-Fca-036075	Felis catus	85.74	0.00e+00	717.00
IUUC-Fal-037569	Ficedula albicollis	60.47	2.00e-116	412.00
IUUC-Gmo-038588	Gadus morhua	40.51	1.00e-71	263.00
IUUC-Gga-040777	Gallus gallus	58.28	2.00e-118	419.00
IUUC-Gac-042463	Gasterosteus aculeatus	41.11	4.00e-62	232.00
IUUC-Ggo-045269	Gorilla gorilla	85.57	0.00e+00	723.00
IUUC-Hsa-046249	Homo sapiens	84.95	0.00e+00	697.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	86.80	0.00e+00	710.00
IUUC-Lch-049805	Latimeria chalumnae	51.80	2.00e-115	409.00
IUUC-Loc-052377	Lepisosteus oculatus	48.54	4.00e-95	341.00
IUUC-Mcc-055344	Macaca mulatta	85.57	0.00e+00	721.00
IUUC-Meu-055950	Macropus eugenii	63.52	1.00e-127	449.00
IUUC-Mla-059052	Melampsora laricipopulina	36.92	3.00e-10	58.20
IUUC-Mga-060049	Meleagris gallopavo	56.90	1.00e-114	406.00
IUUC-Mmr-061431	Microcebus murinus	88.41	0.00e+00	682.00
IUUC-Mdo-062016	Monodelphis domestica	67.65	2.00e-120	427.00
IUUC-Mmu-063235	Mus musculus	74.54	0.00e+00	651.00
IUUC-Mpu-066449	Mustela putorius furo	89.09	0.00e+00	750.00
IUUC-Mlu-067588	Myotis lucifugus	80.12	6.00e-177	613.00
IUUC-Nle-069192	Nomascus leucogenys	85.36	0.00e+00	717.00
IUUC-Opr-070300	Ochotona princeps	67.51	5.00e-148	517.00
IUUC-Ont-071998	Oreochromis niloticus	41.93	8.00e-66	244.00
IUUC-Oan-073610	Ornithorhynchus anatinus	66.67	8.00e-67	246.00
IUUC-Ocu-074603	Oryctolagus cuniculus	80.45	0.00e+00	641.00
IUUC-Ola-086681	Oryzias latipes	41.10	2.00e-72	266.00
IUUC-Oar-090255	Ovis aries	86.16	1.00e-167	582.00
IUUC-Ptr-091029	Pan troglodytes	84.25	0.00e+00	651.00
IUUC-Pan-092241	Papio anubis	85.77	0.00e+00	725.00
IUUC-Psi-093506	Pelodiscus sinensis	60.25	2.00e-129	455.00
IUUC-Pma-094579	Petromyzon marinus	56.67	2.00e-26	113.00
IUUC-Pfo-097014	Poecilia formosa	42.92	4.00e-66	245.00
IUUC-Pab-098530	Pongo abelii	85.25	0.00e+00	668.00
IUUC-Pca-100939	Procavia capensis	63.64	5.00e-144	504.00
IUUC-Pva-103148	Pteropus vampyrus	80.25	0.00e+00	647.00
IUUC-Rno-105338	Rattus norvegicus	75.72	0.00e+00	670.00
IUUC-Sce-106282	Saccharomyces cerevisiae	34.83	3.00e-06	46.60
IUUC-Sha-107187	Sarcophilus harrisii	65.93	2.00e-103	369.00
IUUC-Sar-113356	Sorex araneus	66.58	8.00e-132	463.00
IUUC-Ssc-116290	Sus scrofa	87.14	0.00e+00	758.00
IUUC-Tru-117910	Takifugu rubripes	40.86	7.00e-62	231.00
IUUC-Tsy-119329	Tarsius syrichta	79.91	3.00e-169	587.00
IUUC-Tni-120521	Tetraodon nigroviridis	40.34	1.00e-61	230.00
IUUC-Tme-126989	Tuber melanosporum	32.20	8.00e-07	48.90
IUUC-Ttr-128997	Tursiops truncatus	80.40	0.00e+00	629.00
IUUC-Vpa-130154	Vicugna pacos	83.88	0.00e+00	698.00
IUUC-Xtr-132805	Xenopus tropicalis	50.31	3.00e-105	375.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence