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Tag Content
iUUCD ID IUUC-Ocu-074222
Ensembl Protein ID ENSOCUP00000021074.2
UniProt Accession P63150; P50409; Q00007; 2ABA_RABIT
Genbank Protein ID AAA18497.1
Protein Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha
Genbank Nucleotide ID U09356
Gene Name PPP2R2A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000027088.2 ENSOCUT00000030174.2 ENSOCUP00000021074.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.00e-12 45.2 227 257
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 4    dsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           + +t+ +f  ++ +++v +s  gti+++D+r
   Q: 227  EVITAAEFhpNScNTFVYSSSKGTIRLCDMR 257
           5689999**744799999999********87 PP
   
Organism Oryctolagus cuniculus
Functional Description
(View)

Functional Description


     PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with TP53 (By similarity). Interacts with IER5 (By similarity).
 PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with TP53 (By similarity). Interacts with IER5 (By similarity).
Protein Sequence
(Fasta)
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE 60
NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK 120
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Protein Fasta Sequence


>IUUC-Ocu-074222|E3,WD_repeat|Oryctolagus cuniculus
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Nucleotide Sequence
(Fasta)
ATGGCAGGTA AAGGAGAAAT CCCCCTCGCC CACTGATCCG GCGATGCTTC CCTCCTCCTC 60
CTTCCATCAC CCCCTAGCGA CCGCTCGTGC CTCTCGCGGA GCCCCGGGGC TCCCCCCGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074222|E3,WD_repeat|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS01024--PR55_1
PS01025--PR55_2
PRINTS

PR00600--PP2APR55
SMART

SM00320--WD40
Gene Ontology

GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006470--P:protein dephosphorylation
GO:0043278--P:response to morphine
KEGG ocu:100328616
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001197 Ailuropoda melanoleuca 100.00 0.00e+00 888.00
IUUC-Atr-002517 Amborella trichopoda 50.00 3.00e-127 448.00
IUUC-Apl-004226 Anas platyrhynchos 98.88 0.00e+00 881.00
IUUC-Aca-005147 Anolis carolinensis 99.11 0.00e+00 880.00
IUUC-Acl-008202 Aspergillus clavatus 55.15 4.00e-131 461.00
IUUC-Afl-008646 Aspergillus flavus 56.03 2.00e-133 469.00
IUUC-Afu-009027 Aspergillus fumigatus 55.79 8.00e-133 466.00
IUUC-Ani-009191 Aspergillus nidulans 55.46 7.00e-134 470.00
IUUC-Ang-009769 Aspergillus niger 56.10 1.00e-135 476.00
IUUC-Aor-010030 Aspergillus oryzae 55.82 6.00e-132 464.00
IUUC-Ate-010549 Aspergillus terreus 55.39 7.00e-132 464.00
IUUC-Ame-011776 Astyanax mexicanus 92.63 0.00e+00 826.00
IUUC-Bta-012702 Bos taurus 100.00 0.00e+00 885.00
IUUC-Bci-013801 Botrytis cinerea 54.15 2.00e-137 482.00
IUUC-Bdi-014767 Brachypodium distachyon 50.52 8.00e-126 443.00
IUUC-Bol-015921 Brassica oleracea 50.71 1.00e-135 476.00
IUUC-Bra-017400 Brassica rapa 50.71 3.00e-135 475.00
IUUC-Cel-018618 Caenorhabditis elegans 65.33 2.00e-173 601.00
IUUC-Cja-019036 Callithrix jacchus 100.00 0.00e+00 884.00
IUUC-Cfa-021248 Canis familiaris 100.00 0.00e+00 884.00
IUUC-Cpo-022172 Cavia porcellus 100.00 0.00e+00 884.00
IUUC-Cre-022876 Chlamydomonas reinhardtii 52.21 9.00e-133 466.00
IUUC-Csa-023864 Chlorocebus sabaeus 100.00 0.00e+00 889.00
IUUC-Cin-025380 Ciona intestinalis 77.30 0.00e+00 706.00
IUUC-Csv-026097 Ciona savignyi 75.74 0.00e+00 696.00
IUUC-Cgl-026750 Colletotrichum gloeosporioides 53.96 1.00e-132 466.00
IUUC-Dre-027406 Danio rerio 92.00 0.00e+00 818.00
IUUC-Dno-028876 Dasypus novemcinctus 89.32 0.00e+00 810.00
IUUC-Dor-030390 Dipodomys ordii 85.24 0.00e+00 724.00
IUUC-Dse-031305 Dothistroma septosporum 54.13 4.00e-134 471.00
IUUC-Dme-032131 Drosophila melanogaster 80.18 0.00e+00 724.00
IUUC-Eca-033584 Equus caballus 100.00 0.00e+00 853.00
IUUC-Fca-035565 Felis catus 95.73 0.00e+00 837.00
IUUC-Fal-036821 Ficedula albicollis 98.43 0.00e+00 874.00
IUUC-Fox-037988 Fusarium oxysporum 54.99 7.00e-133 467.00
IUUC-Fso-038460 Fusarium solani 54.07 4.00e-134 471.00
IUUC-Gmo-038834 Gadus morhua 92.17 0.00e+00 811.00
IUUC-Ggr-039883 Gaeumannomyces graminis 53.65 3.00e-134 471.00
IUUC-Gga-041009 Gallus gallus 99.32 0.00e+00 878.00
IUUC-Gac-042418 Gasterosteus aculeatus 88.81 0.00e+00 815.00
IUUC-Gma-044088 Glycine max 50.59 8.00e-130 457.00
IUUC-Ggo-044599 Gorilla gorilla 100.00 0.00e+00 884.00
IUUC-Hsa-046718 Homo sapiens 100.00 0.00e+00 884.00
IUUC-Itr-048651 Ictidomys tridecemlineatus 100.00 0.00e+00 889.00
IUUC-Kpa-049100 Komagataella pastoris 52.19 6.00e-133 467.00
IUUC-Lch-050528 Latimeria chalumnae 96.21 0.00e+00 827.00
IUUC-Loc-052663 Lepisosteus oculatus 88.75 0.00e+00 828.00
IUUC-Laf-053403 Loxodonta africana 99.78 0.00e+00 887.00
IUUC-Mcc-055776 Macaca mulatta 100.00 0.00e+00 880.00
IUUC-Meu-056756 Macropus eugenii 83.33 0.00e+00 698.00
IUUC-Mor-057270 Magnaporthe oryzae 53.33 7.00e-133 467.00
IUUC-Mpo-057327 Magnaporthe poae 54.41 5.00e-135 474.00
IUUC-Mtr-058561 Medicago truncatula 49.50 7.00e-126 444.00
IUUC-Mla-059127 Melampsora laricipopulina 56.85 1.00e-147 516.00
IUUC-Mga-059946 Meleagris gallopavo 98.88 0.00e+00 881.00
IUUC-Mvi-060503 Microbotryum violaceum 60.61 2.00e-107 382.00
IUUC-Mmr-061468 Microcebus murinus 89.55 0.00e+00 813.00
IUUC-Mdo-062340 Monodelphis domestica 99.11 0.00e+00 882.00
IUUC-Mmu-064151 Mus musculus 100.00 0.00e+00 889.00
IUUC-Mac-065244 Musa acuminata 50.51 1.00e-126 446.00
IUUC-Mpu-066190 Mustela putorius furo 100.00 0.00e+00 888.00
IUUC-Mlu-068197 Myotis lucifugus 99.76 0.00e+00 850.00
IUUC-Nfi-068532 Neosartorya fischeri 55.79 5.00e-133 467.00
IUUC-Ncr-068905 Neurospora crassa 53.96 1.00e-135 476.00
IUUC-Nle-069966 Nomascus leucogenys 97.98 0.00e+00 853.00
IUUC-Ont-071603 Oreochromis niloticus 91.29 0.00e+00 810.00
IUUC-Oan-073540 Ornithorhynchus anatinus 97.65 1.00e-168 584.00
IUUC-Obr-076686 Oryza brachyantha 51.87 9.00e-135 473.00
IUUC-Opu-083739 Oryza punctata 51.72 4.00e-135 474.00
IUUC-Oru-084892 Oryza rufipogon 51.31 2.00e-134 472.00
IUUC-Ola-087128 Oryzias latipes 89.82 0.00e+00 790.00
IUUC-Olu-087882 Ostreococcus lucimarinus 50.41 5.00e-128 451.00
IUUC-Oga-089168 Otolemur garnettii 99.78 0.00e+00 887.00
IUUC-Oar-089815 Ovis aries 99.55 0.00e+00 885.00
IUUC-Ptr-091110 Pan troglodytes 100.00 0.00e+00 884.00
IUUC-Pan-092884 Papio anubis 100.00 0.00e+00 889.00
IUUC-Psi-093292 Pelodiscus sinensis 90.41 0.00e+00 818.00
IUUC-Pno-094992 Phaeosphaeria nodorum 54.32 2.00e-134 472.00
IUUC-Ppa-095378 Physcomitrella patens 50.30 6.00e-132 464.00
IUUC-Pfo-097312 Poecilia formosa 90.56 0.00e+00 832.00
IUUC-Pab-098146 Pongo abelii 100.00 0.00e+00 889.00
IUUC-Pca-100882 Procavia capensis 99.60 1.00e-140 493.00
IUUC-Pva-102176 Pteropus vampyrus 92.39 0.00e+00 829.00
IUUC-Ptt-103844 Puccinia triticina 56.82 1.00e-142 499.00
IUUC-Pte-104403 Pyrenophora teres 54.26 2.00e-134 471.00
IUUC-Pyt-104776 Pyrenophora triticirepentis 54.13 6.00e-134 470.00
IUUC-Rno-105484 Rattus norvegicus 99.78 0.00e+00 889.00
IUUC-Sha-107382 Sarcophilus harrisii 99.52 0.00e+00 850.00
IUUC-Spo-108186 Schizosaccharomyces pombe 55.31 7.00e-133 467.00
IUUC-Smo-109273 Selaginella moellendorffii 52.09 1.00e-134 473.00
IUUC-Sly-111422 Solanum lycopersicum 51.51 8.00e-130 457.00
IUUC-Sbi-114402 Sorghum bicolor 50.90 8.00e-132 463.00
IUUC-Ssc-115355 Sus scrofa 100.00 0.00e+00 889.00
IUUC-Tgu-116737 Taeniopygia guttata 98.66 0.00e+00 879.00
IUUC-Tru-118130 Takifugu rubripes 91.22 0.00e+00 805.00
IUUC-Tsy-119206 Tarsius syrichta 96.85 0.00e+00 838.00
IUUC-Tni-120009 Tetraodon nigroviridis 91.22 0.00e+00 805.00
IUUC-Tca-121708 Theobroma cacao 50.00 3.00e-129 455.00
IUUC-Tre-122188 Trichoderma reesei 54.78 4.00e-132 464.00
IUUC-Tvi-122271 Trichoderma virens 54.53 3.00e-133 468.00
IUUC-Tbe-127340 Tupaia belangeri 85.48 0.00e+00 726.00
IUUC-Ttr-128725 Tursiops truncatus 99.78 0.00e+00 881.00
IUUC-Vda-130007 Verticillium dahliae 53.96 2.00e-133 469.00
IUUC-Vpa-130425 Vicugna pacos 95.95 0.00e+00 862.00
IUUC-Vvi-130930 Vitis vinifera 51.51 1.00e-128 452.00
IUUC-Xtr-131852 Xenopus tropicalis 94.03 0.00e+00 868.00
IUUC-Xma-133921 Xiphophorus maculatus 90.77 0.00e+00 837.00
Created Date 25-Jun-2017

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