iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053493

UUCD1 version

UUC-LoA-01076

Ensembl Protein ID

ENSLAFP00000014241.3

UniProt Accession

G3TI04; G3TI04_LOXAF

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP33

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000016986.3	ENSLAFT00000016987.3	ENSLAFP00000014241.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-114	382.7	154	684

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+     +   +++++k +++ks+ kl++elw ks+ ++v p++l++ +k++++ f+gy+
   Q: 154  TGLKNIGNTCYMNAALQALSNCPPLTQFFLD-----CGGLARTDKKPAICKSYLKLMTELWhKSRPGSVVPTNLFQGIKTVNPTFRGYS 237
           7******************************.....999999*******************99************************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqDaqEfl++l+d l+eelk+         +  ++ee++eedks+++ +                                        
   Q: 238  QQDAQEFLRCLMDLLHEELKEqvmeveedTHAITTEESMEEDKSQSDVDfqscescgssdkaenengsrgfsednnettmliqedenns 326
           *******************8877777654444444444444444444449*************************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 327  emskdwqrekmcnkinkinsegeldknrdsvsetvnlnnqetvkvqihsraseyitdvhlndlstphilpsnegvnprlsasppksgnl 415
           ***************************************************************************************** PP
   S: 130  .................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke................ 185
                            +++k++kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+dlslp+pgke+ +k+                
   Q: 416  wpglapthkkaqsvsspKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLhssshptsivkagscg 504
           ********************************************************************99888**************** PP
   S: 186  .................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
                                            +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++k+Pe+L++hLkRf  ++
   Q: 505  eayapqgwiaffmeyvkrfvvscvpswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRF--RH 591
           *************************************************************************************..99 PP
   S: 242  eqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgs 328
           e ++++ki+++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e++v++   +
   Q: 592  ELMFSTKISTHVSFPLEgLDLQPFLAKDSPAQ--IVTYDLLSVICHHGTASSGHYIAYCRNNLNNlWYEFDDQSVTEVSESTVQN---A 675
           99*************************88777..9**************************88889*******************...* PP
   S: 329  taYvlfYkr 337
           +aYvlfY++
   Q: 676  EAYVLFYRK 684
           *******98 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSAFRNHCPH LDSVGEITKE DLIQKSYGTC QDCKVRGPNL WACLESRCSY VGCGESQVDH 60
STTHSQETKH YLTVNLTTLR VWCYACSKEV FLDRKLGTQP SSPNVRQQHS TQENSVQDFK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCAGCTT TTCGAAATCA TTGTCCACAT TTGGATTCAG TTGGAGAAAT AACAAAAGAA 60
GATTTAATAC AAAAATCTTA CGTAAGATAT AGATTTTCTT TCTTCATAAA AAACCAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005776--C:autophagosome
GO:0044297--C:cell body
GO:0005813--C:centrosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0009267--P:cellular response to starvation
GO:0051298--P:centrosome duplication
GO:0032091--P:negative regulation of protein binding
GO:0032092--P:positive regulation of protein binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	95.85	0.00e+00	1784.00
IUUC-Apl-003987	Anas platyrhynchos	82.21	0.00e+00	1478.00
IUUC-Aca-004713	Anolis carolinensis	76.64	0.00e+00	1390.00
IUUC-Bta-013132	Bos taurus	94.97	0.00e+00	1764.00
IUUC-Cja-018811	Callithrix jacchus	95.30	0.00e+00	1773.00
IUUC-Cfa-021158	Canis familiaris	95.41	0.00e+00	1776.00
IUUC-Cpo-021910	Cavia porcellus	87.96	0.00e+00	1578.00
IUUC-Csa-023130	Chlorocebus sabaeus	95.62	0.00e+00	1776.00
IUUC-Cho-024383	Choloepus hoffmanni	79.53	0.00e+00	676.00
IUUC-Dre-028639	Danio rerio	70.39	0.00e+00	1252.00
IUUC-Dno-029416	Dasypus novemcinctus	94.86	0.00e+00	1716.00
IUUC-Ete-032994	Echinops telfairi	81.21	0.00e+00	879.00
IUUC-Eca-034248	Equus caballus	95.84	0.00e+00	1783.00
IUUC-Eeu-035357	Erinaceus europaeus	76.15	0.00e+00	1295.00
IUUC-Fca-036013	Felis catus	93.11	0.00e+00	1714.00
IUUC-Fal-037509	Ficedula albicollis	81.53	0.00e+00	1483.00
IUUC-Gmo-038944	Gadus morhua	66.10	0.00e+00	1181.00
IUUC-Gga-040647	Gallus gallus	81.44	0.00e+00	1469.00
IUUC-Gac-041752	Gasterosteus aculeatus	69.41	0.00e+00	1263.00
IUUC-Hsa-045694	Homo sapiens	95.19	0.00e+00	1762.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	95.41	0.00e+00	1742.00
IUUC-Lch-050400	Latimeria chalumnae	69.93	0.00e+00	1272.00
IUUC-Loc-052616	Lepisosteus oculatus	72.40	0.00e+00	1328.00
IUUC-Mcc-055542	Macaca mulatta	95.84	0.00e+00	1779.00
IUUC-Meu-056645	Macropus eugenii	73.36	0.00e+00	1291.00
IUUC-Mga-060019	Meleagris gallopavo	83.05	0.00e+00	1272.00
IUUC-Mmr-061241	Microcebus murinus	92.01	0.00e+00	1695.00
IUUC-Mmu-063786	Mus musculus	91.36	0.00e+00	1675.00
IUUC-Mpu-065772	Mustela putorius furo	95.47	0.00e+00	1477.00
IUUC-Mlu-067732	Myotis lucifugus	93.68	0.00e+00	1744.00
IUUC-Nle-069528	Nomascus leucogenys	94.97	0.00e+00	1780.00
IUUC-Opr-070606	Ochotona princeps	89.39	0.00e+00	1563.00
IUUC-Ont-071495	Oreochromis niloticus	70.75	0.00e+00	1276.00
IUUC-Oan-073695	Ornithorhynchus anatinus	85.36	0.00e+00	1052.00
IUUC-Ocu-074457	Oryctolagus cuniculus	91.64	0.00e+00	1706.00
IUUC-Ola-086739	Oryzias latipes	70.10	0.00e+00	1306.00
IUUC-Oga-088720	Otolemur garnettii	94.74	0.00e+00	1768.00
IUUC-Oar-089921	Ovis aries	94.97	0.00e+00	1767.00
IUUC-Ptr-090526	Pan troglodytes	95.19	0.00e+00	1763.00
IUUC-Pan-092396	Papio anubis	95.53	0.00e+00	1770.00
IUUC-Psi-092971	Pelodiscus sinensis	82.64	0.00e+00	1535.00
IUUC-Pfo-097415	Poecilia formosa	70.25	0.00e+00	1280.00
IUUC-Pab-098740	Pongo abelii	95.40	0.00e+00	1794.00
IUUC-Pca-100598	Procavia capensis	82.99	0.00e+00	895.00
IUUC-Pva-102820	Pteropus vampyrus	91.53	0.00e+00	1491.00
IUUC-Rno-104894	Rattus norvegicus	91.48	0.00e+00	1690.00
IUUC-Sha-107244	Sarcophilus harrisii	77.52	0.00e+00	1406.00
IUUC-Sar-113665	Sorex araneus	92.56	0.00e+00	1731.00
IUUC-Ssc-115793	Sus scrofa	93.01	0.00e+00	1701.00
IUUC-Tgu-117487	Taeniopygia guttata	82.53	0.00e+00	1453.00
IUUC-Tru-117694	Takifugu rubripes	67.78	0.00e+00	1271.00
IUUC-Tsy-119598	Tarsius syrichta	83.09	0.00e+00	1449.00
IUUC-Tni-120189	Tetraodon nigroviridis	66.38	0.00e+00	1202.00
IUUC-Tbe-128125	Tupaia belangeri	85.77	2.00e-111	397.00
IUUC-Ttr-128269	Tursiops truncatus	91.47	0.00e+00	1632.00
IUUC-Vpa-130598	Vicugna pacos	93.44	0.00e+00	1727.00
IUUC-Xtr-132044	Xenopus tropicalis	74.59	0.00e+00	1322.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence