iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089921

Ensembl Protein ID

ENSOARP00000013963.1

UniProt Accession

W5PU32; W5PU32_SHEEP

Genbank Protein ID

ENSOARP00000013963

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AMGL01002653

Gene Name

USP33

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000013032.1	ENSOART00000014170.1	ENSOARP00000013963.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.60e-114	381.7	185	715

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+     +   +++++k +++ks+ kl++elw ks+ ++v p++l++ +k++++ f+gy+
   Q: 185  TGLKNIGNTCYMNAALQALSNCPPLTQFFLD-----CGGLARTDKKPAICKSYLKLMTELWhKSRPGSVVPTTLFQGIKTVNPTFRGYS 268
           7******************************.....999999*******************99************************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqDaqEfl++l+d l+eelk+         ++  +ee++eedks+++ +                                        
   Q: 269  QQDAQEFLRCLMDLLHEELKEqvmeveedPQTIMTEETMEEDKSQSDVDfqscescsssdkaenengsrsfsednnettmliqddenns 357
           *******************8889988866666666666666666666669*************************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 358  emskdwqkekmcnkinkvnsegeldkdrdsvsetadlnnqetvkvqihsraseyitdvhlndlstpqilpsnegvnprlsasppksgnl 446
           ***************************************************************************************** PP
   S: 130  .................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke................ 185
                            +++k++kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+dlslp+pgke+ +k+                
   Q: 447  wpglppthkkvqsalspKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLhssshptsivkagscg 535
           ********************************************************************99888**************** PP
   S: 186  .................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
                                            +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++k+Pe+L++hLkRf  ++
   Q: 536  eayapqgwiaffmeyvkrfvvscvpswfwgpivTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRF--RH 622
           *************************************************************************************..99 PP
   S: 242  eqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgs 328
           e ++++ki+++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e++v++   +
   Q: 623  ELMFSTKISTHVSFPLEgLDLQPFLAKDSPAQ--IVNYDLLSVICHHGTASSGHYIAYCRNNLNNlWYEFDDQSVTEVSESTVQN---A 706
           99*************************88777..9**************************88889*******************...* PP
   S: 329  taYvlfYkr 337
           +aYvlfY++
   Q: 707  EAYVLFYRK 715
           *******98 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

LFNSNSSLKI STFKVLPHLE SLEKLENISN KMSSFRSHCP HLDSVGEITK EDLIQKSHGS 60
CQDCKVRGPN LWACLENRCS YVGCGESQVD HSTIHSQETK HYLTVNLTTL RVWCYACSKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTCAATT CCAATTCTAG CCTAAAGGTT AATCTTTTTA AAAGAAAAAT AGGGGATGTA 60
AATACTTAAA TAACCTGATG TTTTTTCCCT TTCATCTACC TCAAAAACTG AACTTGGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005776--C:autophagosome
GO:0044297--C:cell body
GO:0005813--C:centrosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0009267--P:cellular response to starvation
GO:0051298--P:centrosome duplication
GO:0032091--P:negative regulation of protein binding
GO:0032092--P:positive regulation of protein binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	96.38	0.00e+00	1828.00
IUUC-Apl-003987	Anas platyrhynchos	82.39	0.00e+00	1496.00
IUUC-Aca-004713	Anolis carolinensis	76.81	0.00e+00	1421.00
IUUC-Bta-013132	Bos taurus	99.56	0.00e+00	1843.00
IUUC-Cja-018811	Callithrix jacchus	96.15	0.00e+00	1822.00
IUUC-Cfa-021158	Canis familiaris	95.46	0.00e+00	1823.00
IUUC-Cpo-021910	Cavia porcellus	88.84	0.00e+00	1586.00
IUUC-Csa-023130	Chlorocebus sabaeus	97.04	0.00e+00	1801.00
IUUC-Cho-024383	Choloepus hoffmanni	78.79	0.00e+00	690.00
IUUC-Csv-025889	Ciona savignyi	43.87	1.00e-35	142.00
IUUC-Dre-028639	Danio rerio	70.09	0.00e+00	1254.00
IUUC-Dno-029416	Dasypus novemcinctus	94.74	0.00e+00	1724.00
IUUC-Dme-031837	Drosophila melanogaster	44.36	1.00e-129	457.00
IUUC-Ete-032994	Echinops telfairi	79.52	0.00e+00	880.00
IUUC-Eca-034248	Equus caballus	96.34	0.00e+00	1823.00
IUUC-Eeu-035357	Erinaceus europaeus	76.53	0.00e+00	1325.00
IUUC-Fca-036013	Felis catus	94.25	0.00e+00	1743.00
IUUC-Fal-037509	Ficedula albicollis	81.93	0.00e+00	1493.00
IUUC-Gmo-038944	Gadus morhua	65.63	0.00e+00	1194.00
IUUC-Gga-040647	Gallus gallus	82.17	0.00e+00	1484.00
IUUC-Gac-041752	Gasterosteus aculeatus	69.97	0.00e+00	1275.00
IUUC-Hsa-045694	Homo sapiens	95.33	0.00e+00	1821.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	95.95	0.00e+00	1751.00
IUUC-Lch-050400	Latimeria chalumnae	71.30	0.00e+00	1295.00
IUUC-Loc-052616	Lepisosteus oculatus	72.11	0.00e+00	1338.00
IUUC-Laf-053493	Loxodonta africana	94.97	0.00e+00	1769.00
IUUC-Mcc-055542	Macaca mulatta	96.16	0.00e+00	1828.00
IUUC-Meu-056645	Macropus eugenii	73.62	0.00e+00	1305.00
IUUC-Mga-060019	Meleagris gallopavo	82.75	0.00e+00	1272.00
IUUC-Mmr-061241	Microcebus murinus	92.25	0.00e+00	1756.00
IUUC-Mmu-063786	Mus musculus	92.00	0.00e+00	1685.00
IUUC-Mpu-065772	Mustela putorius furo	97.19	0.00e+00	1498.00
IUUC-Mlu-067732	Myotis lucifugus	94.78	0.00e+00	1800.00
IUUC-Nle-069528	Nomascus leucogenys	95.83	0.00e+00	1793.00
IUUC-Opr-070606	Ochotona princeps	89.56	0.00e+00	1595.00
IUUC-Ont-071495	Oreochromis niloticus	71.35	0.00e+00	1283.00
IUUC-Oan-073695	Ornithorhynchus anatinus	85.51	0.00e+00	1057.00
IUUC-Ocu-074457	Oryctolagus cuniculus	92.83	0.00e+00	1734.00
IUUC-Ola-086739	Oryzias latipes	70.21	0.00e+00	1320.00
IUUC-Oga-088720	Otolemur garnettii	94.54	0.00e+00	1795.00
IUUC-Ptr-090526	Pan troglodytes	96.13	0.00e+00	1816.00
IUUC-Pan-092396	Papio anubis	96.17	0.00e+00	1823.00
IUUC-Psi-092971	Pelodiscus sinensis	82.97	0.00e+00	1560.00
IUUC-Pfo-097415	Poecilia formosa	70.26	0.00e+00	1286.00
IUUC-Pab-098740	Pongo abelii	96.71	0.00e+00	1817.00
IUUC-Pca-100598	Procavia capensis	83.49	0.00e+00	902.00
IUUC-Pva-102820	Pteropus vampyrus	92.93	0.00e+00	1546.00
IUUC-Rno-104894	Rattus norvegicus	92.11	0.00e+00	1707.00
IUUC-Sha-107244	Sarcophilus harrisii	77.80	0.00e+00	1409.00
IUUC-Sar-113665	Sorex araneus	93.11	0.00e+00	1787.00
IUUC-Ssc-115793	Sus scrofa	94.52	0.00e+00	1725.00
IUUC-Tgu-117487	Taeniopygia guttata	83.39	0.00e+00	1468.00
IUUC-Tru-117694	Takifugu rubripes	69.05	0.00e+00	1294.00
IUUC-Tsy-119598	Tarsius syrichta	83.59	0.00e+00	1481.00
IUUC-Tni-120189	Tetraodon nigroviridis	67.46	0.00e+00	1222.00
IUUC-Tbe-128125	Tupaia belangeri	83.59	9.00e-117	414.00
IUUC-Ttr-128269	Tursiops truncatus	93.86	0.00e+00	1697.00
IUUC-Vpa-130598	Vicugna pacos	94.73	0.00e+00	1782.00
IUUC-Xtr-132044	Xenopus tropicalis	75.41	0.00e+00	1339.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence