iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088862

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAQR03060988

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000015223.2	ENSOGAT00000015226.2	ENSOGAP00000013630.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.40e-98	328.6	253	656

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp............................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+ +++++++  p                                               
   Q: 253  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSQTEHLFPkaangkpqlsgrlasssatelssrsdraeacereglcrnsgasvtrs 341
           7******************************7777777666667777778************************************999 PP
   S: 43   .........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeed 122
                    ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++
   Q: 342  leliqnkepSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTT 421
           99999999999999************************************************************.........668888 PP
   S: 123  kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeele 201
           ++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e le
   Q: 422  RRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCVSCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALE 510
           8999999***************************************************998879************************* PP
   S: 202  genkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkk 277
           g+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  
   Q: 511  GRI-YACDQCNSKRRksnpkplvlteARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDMLSSLDkeTFA 597
           965.*******999999999999999***********************997.8889********************876654433999 PP
   S: 278  YeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 598  YDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 656
           *************************9999********************...********98 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCMECA TTESVWACLK CSHVACGRYI EDHALKHFEE 60
SGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGKKEDQL MRRGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT AGGGCGGTTA CGGCTCGCCC AGGACCACTC CATCCTGAAC 60
CCTCAGAAGT GGTGCTGCAT GGAGTGCGCC ACCACCGAGT CTGTGTGGGC TTGTCTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	95.78	0.00e+00	853.00
IUUC-Apl-003658	Anas platyrhynchos	78.77	0.00e+00	1063.00
IUUC-Aca-005278	Anolis carolinensis	78.91	0.00e+00	1078.00
IUUC-Bta-012911	Bos taurus	89.26	0.00e+00	1136.00
IUUC-Cja-019171	Callithrix jacchus	94.18	0.00e+00	1254.00
IUUC-Cfa-020408	Canis familiaris	90.10	0.00e+00	1175.00
IUUC-Cpo-022233	Cavia porcellus	83.29	0.00e+00	1075.00
IUUC-Csa-024272	Chlorocebus sabaeus	93.07	0.00e+00	1028.00
IUUC-Cho-025051	Choloepus hoffmanni	89.14	0.00e+00	647.00
IUUC-Dno-029856	Dasypus novemcinctus	90.84	0.00e+00	1195.00
IUUC-Ete-032761	Echinops telfairi	73.17	0.00e+00	850.00
IUUC-Eca-033851	Equus caballus	81.89	0.00e+00	1008.00
IUUC-Fal-037290	Ficedula albicollis	76.56	0.00e+00	951.00
IUUC-Gmo-039249	Gadus morhua	77.04	2.00e-145	509.00
IUUC-Gac-042595	Gasterosteus aculeatus	61.24	0.00e+00	759.00
IUUC-Ggo-044979	Gorilla gorilla	93.45	0.00e+00	1256.00
IUUC-Hsa-046743	Homo sapiens	93.30	0.00e+00	1251.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	91.57	0.00e+00	1229.00
IUUC-Lch-050294	Latimeria chalumnae	76.07	0.00e+00	969.00
IUUC-Loc-051961	Lepisosteus oculatus	68.05	0.00e+00	813.00
IUUC-Laf-053819	Loxodonta africana	93.46	0.00e+00	847.00
IUUC-Mcc-055048	Macaca mulatta	94.18	0.00e+00	1264.00
IUUC-Meu-055971	Macropus eugenii	67.32	8.00e-151	527.00
IUUC-Mmr-061253	Microcebus murinus	87.30	8.00e-158	550.00
IUUC-Mdo-062073	Monodelphis domestica	81.86	0.00e+00	1109.00
IUUC-Mmu-064095	Mus musculus	90.12	0.00e+00	1197.00
IUUC-Mpu-066318	Mustela putorius furo	94.76	0.00e+00	869.00
IUUC-Mlu-067090	Myotis lucifugus	87.94	0.00e+00	1155.00
IUUC-Nle-069486	Nomascus leucogenys	93.89	0.00e+00	1261.00
IUUC-Opr-070563	Ochotona princeps	88.86	0.00e+00	1198.00
IUUC-Oan-073245	Ornithorhynchus anatinus	89.14	0.00e+00	627.00
IUUC-Ocu-074851	Oryctolagus cuniculus	88.70	0.00e+00	943.00
IUUC-Ola-086413	Oryzias latipes	59.48	0.00e+00	734.00
IUUC-Oar-089462	Ovis aries	91.10	0.00e+00	812.00
IUUC-Ptr-091525	Pan troglodytes	92.97	0.00e+00	1125.00
IUUC-Pan-092363	Papio anubis	94.11	0.00e+00	1213.00
IUUC-Psi-093353	Pelodiscus sinensis	80.52	0.00e+00	1080.00
IUUC-Pma-094155	Petromyzon marinus	59.73	7.00e-85	306.00
IUUC-Pfo-096413	Poecilia formosa	61.29	0.00e+00	779.00
IUUC-Pab-098592	Pongo abelii	92.03	0.00e+00	1014.00
IUUC-Pca-100449	Procavia capensis	89.44	0.00e+00	1206.00
IUUC-Pva-102868	Pteropus vampyrus	89.83	0.00e+00	1170.00
IUUC-Rno-105190	Rattus norvegicus	88.95	0.00e+00	1199.00
IUUC-Sha-107337	Sarcophilus harrisii	82.22	0.00e+00	1093.00
IUUC-Sar-113561	Sorex araneus	95.21	2.00e-95	342.00
IUUC-Ssc-115735	Sus scrofa	90.26	0.00e+00	1168.00
IUUC-Tgu-117025	Taeniopygia guttata	71.12	0.00e+00	872.00
IUUC-Tru-117585	Takifugu rubripes	60.99	0.00e+00	764.00
IUUC-Tsy-118814	Tarsius syrichta	92.73	0.00e+00	1223.00
IUUC-Tni-120600	Tetraodon nigroviridis	61.15	0.00e+00	736.00
IUUC-Xtr-132090	Xenopus tropicalis	69.92	0.00e+00	924.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence