iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046687

Ensembl Protein ID

ENSP00000365131.5

UniProt Accession

P46379; A2ADJ7; A3KQ42; A3KQ44; A6NGY6; A6PWF7; B0UX84; B4DZ12; B4E3V4; E7EMZ4; F8VXY4; O95874; Q5HYL9; Q5SQ35; Q5SQ36; Q5SQ37; Q5SQ41; Q5SRP8; Q5SRP9; Q5STC1; Q5STX1; Q5STX3; Q96SA6; Q9BCN4; BAG6_HUMAN

Genbank Protein ID

AAA35587.1; AAA35588.1; AAA35588.1; CAI46045.1; BAG63924.1; BAG65616.1; AAD18085.1; BAB63390.1; CAI18314.1; CAI18315.1; CAI18316.2; CAI18318.2; CAI17658.1; CAI17658.1; CAI17659.1; CAI17659.1; CAI17784.1; CAI17784.1; CAI17785.1; CAI17785.1; CAI17786.1; CAI17786.1; CAI18501.1; CAI18504.1; CAI18508.2; CAI18509.1; CAM25014.1; CAM25014.1; CAM45799.1; CAM45800.1; CAM45801.1; CAO72072.1; CAO72072.1; CAQ06558.1; CAQ06558.1; CAQ06931.1; CAQ06931.1; CAQ06977.1; CAQ10854.1; EAX03455.1; AAH03133.1

Protein Name

Large proline-rich protein BAG6; BAG family molecular chaperone regulator 6; BCL2-associated athanogene 6; HLA-B-associated transcript 3; Protein G3; Protein Scythe

Genbank Nucleotide ID

M33519; M33521; M33520; BX647244; AK302695; AK304879; AF129756; BA000025; AL662801; AL662801; AL662801; AL662801; AL662847; AL670886; AL662847; AL670886; AL670886; AL662847; AL670886; AL662847; AL670886; AL662847; AL805934; AL805934; AL805934; AL805934; AL670886; AL662847; BX511262; BX511262; BX511262; AL662847; AL670886; CR753842; CR753892; CR753892; CR753842; CR354443; CR759761; CH471081; BC003133

Gene Name

BAG6; BAT3; G3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000204463.12	ENST00000422948.5	ENSP00000413225.1
ENSG00000204463.12	ENST00000441793.5	ENSP00000416633.1
ENSG00000204463.12	ENST00000375976.8	ENSP00000365143.4
ENSG00000204463.12	ENST00000437771.5	ENSP00000397978.1
ENSG00000204463.12	ENST00000438149.5	ENSP00000410280.1
ENSG00000204463.12	ENST00000453833.5	ENSP00000406434.1
ENSG00000204463.12	ENST00000434444.5	ENSP00000394856.1
ENSG00000204463.12	ENST00000375964.10	ENSP00000365131.5
ENSG00000204463.12	ENST00000362049.10	ENSP00000354875.6
ENSG00000204463.12	ENST00000439687.6	ENSP00000402856.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	10675567; 12826399; 15571810

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	1.50e-19	71.4	18	90

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 2    kltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           ++ vktl++++ ++ v  +++v+e+Ke+ia++ ++p e+q+LIy+G++L+Dd++L+e+++  g+v+hlv + ++
   Q: 18   EVLVKTLDSQTRTFIVGAQMNVKEFKEHIAASVSIPSEKQRLIYQGRVLQDDKKLQEYNVG-GKVIHLVERAPP 90
           799*********************************************************9.*******99876 PP

Organism

Homo sapiens

Functional Description
(View)

Mediates ricin-induced apoptosis.

Protein Sequence
(Fasta)

MEPNDSTSTA VEEPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV SIPSEKQRLI 60
YQGRVLQDDK KLQEYNVGGK VIHLVERAPP QTHLPSGASS GTGSASATHG GGSPPGTRGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGTGGGG CGATGCTTAA GTGTCCACGC ATCCGTAGTG CGACGCACGC AGGCGTAGTA 60
CGGTCCCCCG GGCGACAGCG GTGGCGGCTC CTCGGGGTGC TCGGCTCCCT CCCACCTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0391--Immunity
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0744--Spermatogenesis
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR021925--DUF3538
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF12057--DUF3538
PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0071818--C:BAT3 complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0051787--F:misfolded protein binding
GO:0031593--F:polyubiquitin binding
GO:0070628--F:proteasome binding
GO:0005102--F:receptor binding
GO:0043022--F:ribosome binding
GO:0015643--F:toxic substance binding
GO:0031625--F:ubiquitin protein ligase binding
GO:1990381--F:ubiquitin-specific protease binding
GO:0006915--P:apoptotic process
GO:0007420--P:brain development
GO:0030154--P:cell differentiation
GO:0016569--P:covalent chromatin modification
GO:0009790--P:embryo development
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0002429--P:immune response-activating cell surface receptor signaling pathway
GO:0018393--P:internal peptidyl-lysine acetylation
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001822--P:kidney development
GO:0030324--P:lung development
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0030101--P:natural killer cell activation
GO:0043066--P:negative regulation of apoptotic process
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045861--P:negative regulation of proteolysis
GO:1904294--P:positive regulation of ERAD pathway
GO:1904379--P:protein localization to cytosolic proteasome complex involved in ERAD pathway
GO:0050821--P:protein stabilization
GO:0042127--P:regulation of cell proliferation
GO:0007283--P:spermatogenesis
GO:0007130--P:synaptonemal complex assembly
GO:0071816--P:tail-anchored membrane protein insertion into ER membrane
GO:0006810--P:transport
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7917

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002741	Amborella trichopoda	38.52	9.00e-20	92.80
IUUC-Aca-005226	Anolis carolinensis	69.72	3.00e-160	560.00
IUUC-Ang-009826	Aspergillus niger	39.29	9.00e-11	61.20
IUUC-Ame-011606	Astyanax mexicanus	55.47	6.00e-147	515.00
IUUC-Bta-012561	Bos taurus	90.48	0.00e+00	1411.00
IUUC-Bdi-015055	Brachypodium distachyon	42.86	7.00e-13	69.30
IUUC-Bra-017388	Brassica rapa	37.96	2.00e-15	78.20
IUUC-Dno-029388	Dasypus novemcinctus	85.82	0.00e+00	1365.00
IUUC-Fca-036518	Felis catus	88.65	0.00e+00	1435.00
IUUC-Ggr-039961	Gaeumannomyces graminis	36.00	3.00e-07	49.70
IUUC-Gac-041284	Gasterosteus aculeatus	51.63	6.00e-132	465.00
IUUC-Gma-043829	Glycine max	39.13	5.00e-15	76.60
IUUC-Hvu-047806	Hordeum vulgare	44.74	3.00e-12	68.20
IUUC-Laf-053832	Loxodonta africana	97.43	0.00e+00	724.00
IUUC-Mcc-055256	Macaca mulatta	95.03	0.00e+00	1417.00
IUUC-Meu-056280	Macropus eugenii	87.50	3.00e-78	287.00
IUUC-Mmr-061073	Microcebus murinus	87.51	0.00e+00	1399.00
IUUC-Mlu-067697	Myotis lucifugus	91.94	0.00e+00	1142.00
IUUC-Opr-071123	Ochotona princeps	83.92	0.00e+00	1333.00
IUUC-Ont-072239	Oreochromis niloticus	53.69	2.00e-123	437.00
IUUC-Oin-079943	Oryza indica	41.51	3.00e-13	70.50
IUUC-Ome-081937	Oryza meridionalis	41.51	4.00e-13	70.50
IUUC-Oru-085170	Oryza rufipogon	41.51	4.00e-13	70.50
IUUC-Oga-088614	Otolemur garnettii	92.32	0.00e+00	1466.00
IUUC-Oar-090085	Ovis aries	84.54	0.00e+00	1334.00
IUUC-Pan-091999	Papio anubis	98.41	0.00e+00	1431.00
IUUC-Pfo-097252	Poecilia formosa	48.77	2.00e-125	444.00
IUUC-Ppe-101620	Prunus persica	45.45	1.00e-13	72.80
IUUC-Pva-103214	Pteropus vampyrus	90.59	0.00e+00	748.00
IUUC-Rno-105636	Rattus norvegicus	96.22	0.00e+00	729.00
IUUC-Tca-121642	Theobroma cacao	46.43	1.00e-13	72.40
IUUC-Tbe-127897	Tupaia belangeri	98.63	6.00e-152	532.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence