iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000112511.17	ENST00000487667.5	ENSP00000432419.1
ENSG00000112511.17	ENST00000459809.5	ENSP00000479423.1
ENSG00000112511.17	ENST00000374512.7	ENSP00000363636.3
ENSG00000112511.17	ENST00000374516.7	ENSP00000363640.3
ENSG00000112511.17	ENST00000495509.6	ENSP00000434347.1
ENSG00000112511.17	ENST00000427826.1	ENSP00000404788.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	HINT
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.60e-09	39.4	89	140

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedek.slveCekCrewfHpaClklsveeelpnsek.wiCpkCr 52
            C vC++++      lv CekCr+++H++C+ + +  + +++ + w C++C 
   Q: 89   LCCVCRSETVVPGnRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTsWVCRQCV 140
           588***999876459*******************66666655558******7 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAQPPRLSRS GASSLWDPAS PAPTSGPRPR LWEGQDVLAR WTDGLLYLGT IKKVDSAREV 60
CLVQFEDDSQ FLVLWKDISP AALPGEELLC CVCRSETVVP GNRLVSCEKC RHAYHQDCHV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCACGGGG CGGGACGTCC ACGGGAAGCG GCGCGCACGC CCGCCGACTC CCTCGCGCCA 60
ACCGCCGACG GCCGCCGCCC GGTGAAGGAG GGGCTCAGTC CTCCCAGGTG CCGCGCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031202--PHF1
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00628--PHD

SMART

SM00249--PHD
SM00333--TUDOR

Gene Ontology

GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0031060--P:regulation of histone methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011369	Astyanax mexicanus	48.24	1.00e-127	450.00
IUUC-Dre-028597	Danio rerio	47.98	9.00e-132	463.00
IUUC-Gmo-039382	Gadus morhua	65.59	6.00e-119	420.00
IUUC-Gac-041748	Gasterosteus aculeatus	66.13	8.00e-121	426.00
IUUC-Lch-050336	Latimeria chalumnae	52.73	1.00e-149	523.00
IUUC-Mmu-063482	Mus musculus	91.53	0.00e+00	932.00
IUUC-Ont-071655	Oreochromis niloticus	53.67	2.00e-124	439.00
IUUC-Pfo-097260	Poecilia formosa	61.02	7.00e-122	430.00
IUUC-Sha-107357	Sarcophilus harrisii	85.11	0.00e+00	835.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence