iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118196

UUCD1 version

UUC-TaR-01047

Ensembl Protein ID

ENSTRUP00000025509.1

UniProt Accession

H2TLF4; H2TLF4_TAKRU

Protein Name

Uncharacterized protein

Gene Name

UBE2K (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000010130.1	ENSTRUT00000025613.1	ENSTRUP00000025509.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	8.90e-46	156.3	8	146
UBD/UBC-like/UBD_UBC	1.50e-71	240.1	8	149

Active Site

Position(s)	Description	Evidence
92	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkel...ekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsi 85
           R+k+e+ke+   e++++++i +++vde ++te++ +i Gp+dtpYegg ++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+i
   Q: 8    RIKREFKEVlksEETSKNQINVELVDE-NFTELKGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDI 95
           7888888873335556699********.9***************************************************99******* PP
   S: 86   lkeeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           lk  ++W +a+++++vlls+q+lla ++p++p+++ +a+++k+n+e++k+++r
   Q: 96   LK--DQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTAR 146
           *9..**********************************************986 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeea...qisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpnins.ngsicldil 85
           rik+e+k++l++ee+   qi+++lvd++++el+++iagppd+pyegg+++l+ik+p++ypf+ppkv+fitki+hpni+s +g+icldil
   Q: 8    RIKREFKEVLKSEETsknQINVELVDENFTELKGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSvTGAICLDIL 96
           8*************9999*********************************************************************** PP
   S: 86   rsqwsaaltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           ++qw+aa+tl++vllsl++lla+aepddp++a++a++yk+++e++k++ar+w+
   Q: 97   KDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWS 149
           ****************************************************5 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MANIAVQRIK REFKEVLKSE ETSKNQINVE LVDENFTELK GEIAGPPDTP YEGGRYQLEI 60
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATGTTTTC AGTACCACCA TTGTGTCACA CATTTGAGAT GATAGACACA CGTTGAGCTA 60
TTTTTAACGC TTTCTATCCT TAAGCAGGTA ACCGGGAACC CTCGGCGTGT AAGACGTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	51.55	1.00e-28	119.00
IUUC-Aml-001286	Ailuropoda melanoleuca	84.44	4.00e-102	363.00
IUUC-Ago-007714	Ashbya gossypii	44.62	4.00e-38	150.00
IUUC-Acl-008189	Aspergillus clavatus	49.03	6.00e-28	117.00
IUUC-Ame-011454	Astyanax mexicanus	87.11	1.00e-104	372.00
IUUC-Bgr-012255	Blumeria graminis	47.77	2.00e-34	138.00
IUUC-Bta-012992	Bos taurus	84.44	4.00e-102	363.00
IUUC-Bci-013806	Botrytis cinerea	46.78	4.00e-35	140.00
IUUC-Cfa-020016	Canis familiaris	84.44	4.00e-102	363.00
IUUC-Cpo-022026	Cavia porcellus	84.44	4.00e-102	363.00
IUUC-Csa-023059	Chlorocebus sabaeus	84.44	4.00e-102	363.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	43.90	4.00e-34	137.00
IUUC-Cne-027068	Cryptococcus neoformans	47.56	1.00e-40	159.00
IUUC-Dse-031335	Dothistroma septosporum	49.04	4.00e-36	144.00
IUUC-Eca-033428	Equus caballus	84.44	4.00e-102	363.00
IUUC-Fca-035366	Felis catus	84.44	4.00e-102	363.00
IUUC-Fal-037016	Ficedula albicollis	84.44	4.00e-102	363.00
IUUC-Fox-037969	Fusarium oxysporum	44.24	3.00e-34	138.00
IUUC-Fso-038296	Fusarium solani	50.00	7.00e-36	143.00
IUUC-Gmo-039135	Gadus morhua	87.11	4.00e-104	369.00
IUUC-Ggr-039768	Gaeumannomyces graminis	46.25	1.00e-25	109.00
IUUC-Gac-041503	Gasterosteus aculeatus	87.56	5.00e-105	373.00
IUUC-Ggo-045032	Gorilla gorilla	84.44	4.00e-102	363.00
IUUC-Hsa-046490	Homo sapiens	84.44	4.00e-102	363.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	84.44	4.00e-102	363.00
IUUC-Kpa-049297	Komagataella pastoris	50.33	4.00e-35	140.00
IUUC-Lch-050588	Latimeria chalumnae	71.56	4.00e-78	283.00
IUUC-Loc-052549	Lepisosteus oculatus	85.78	1.00e-103	368.00
IUUC-Mcc-055606	Macaca mulatta	84.44	4.00e-102	363.00
IUUC-Mor-056946	Magnaporthe oryzae	38.46	5.00e-23	100.00
IUUC-Mpo-057441	Magnaporthe poae	46.51	5.00e-26	110.00
IUUC-Mvi-060346	Microbotryum violaceum	48.37	6.00e-34	137.00
IUUC-Mmr-061211	Microcebus murinus	84.44	4.00e-102	363.00
IUUC-Mmu-063648	Mus musculus	84.44	4.00e-102	363.00
IUUC-Mpu-066407	Mustela putorius furo	84.44	1.00e-101	362.00
IUUC-Ncr-068749	Neurospora crassa	48.41	8.00e-39	153.00
IUUC-Opr-070651	Ochotona princeps	84.44	4.00e-102	363.00
IUUC-Ont-071595	Oreochromis niloticus	87.56	5.00e-105	373.00
IUUC-Ocu-074939	Oryctolagus cuniculus	84.44	4.00e-102	363.00
IUUC-Ola-087043	Oryzias latipes	87.56	5.00e-105	373.00
IUUC-Ptr-091295	Pan troglodytes	84.44	4.00e-102	363.00
IUUC-Psi-093498	Pelodiscus sinensis	84.44	4.00e-102	363.00
IUUC-Pfo-096174	Poecilia formosa	86.67	2.00e-104	370.00
IUUC-Pab-098279	Pongo abelii	84.44	4.00e-102	363.00
IUUC-Pca-100782	Procavia capensis	84.00	5.00e-100	356.00
IUUC-Pva-102147	Pteropus vampyrus	67.61	1.00e-55	208.00
IUUC-Ptt-103772	Puccinia triticina	47.95	3.00e-37	148.00
IUUC-Rno-104984	Rattus norvegicus	84.44	4.00e-102	363.00
IUUC-Sce-106394	Saccharomyces cerevisiae	46.77	2.00e-36	145.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	46.86	4.00e-39	154.00
IUUC-Sre-115046	Sporisorium reilianum	46.71	5.00e-37	147.00
IUUC-Ssc-116314	Sus scrofa	84.44	4.00e-102	363.00
IUUC-Tni-119667	Tetraodon nigroviridis	87.11	9.00e-105	372.00
IUUC-Tre-122053	Trichoderma reesei	43.33	2.00e-31	128.00
IUUC-Tvi-122533	Trichoderma virens	43.33	3.00e-31	128.00
IUUC-Tme-127024	Tuber melanosporum	50.32	5.00e-39	154.00
IUUC-Tbe-127752	Tupaia belangeri	81.33	5.00e-97	346.00
IUUC-Vda-129947	Verticillium dahliae	45.86	4.00e-31	127.00
IUUC-Xma-134165	Xiphophorus maculatus	87.11	1.00e-104	371.00
IUUC-Yli-134523	Yarrowia lipolytica	38.99	1.00e-34	139.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence