iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020309

Ensembl Protein ID

ENSCAFP00000000505.3

UniProt Accession

E2R4G3; E2R4G3_CANLF

Genbank Protein ID

ENSCAFP00000000505

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03006996

Gene Name

TBK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000000356.3	ENSCAFT00000000555.3	ENSCAFP00000000505.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	93.42	0.00e+00	1449.00	IUUC-Mmu-064107

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Protein Sequence
(Fasta)

MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK 60
KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 120

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Nucleotide Sequence
(Fasta)

ATGCAGAGCA CTTCCAATCA TCTGTGGCTT TTATCTGATA TTTTAGGCCA AGGAGCTACT 60
GCAAATGTCT TTCGTGGAAG GCATAAGGTT GGTTCAGAGA AAACCGTGAA GGCTTTTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0003676--F:nucleic acid binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0002218--P:activation of innate immune response
GO:0050830--P:defense response to Gram-positive bacterium
GO:0044565--P:dendritic cell proliferation
GO:0045087--P:innate immune response
GO:0010629--P:negative regulation of gene expression
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032727--P:positive regulation of interferon-alpha production
GO:0045359--P:positive regulation of interferon-beta biosynthetic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1904417--P:positive regulation of xenophagy

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001638	Ailuropoda melanoleuca	98.63	0.00e+00	1503.00
IUUC-Apl-004028	Anas platyrhynchos	86.97	0.00e+00	1355.00
IUUC-Aca-004998	Anolis carolinensis	82.72	0.00e+00	1290.00
IUUC-Ame-011617	Astyanax mexicanus	71.17	0.00e+00	1066.00
IUUC-Bta-012799	Bos taurus	97.94	0.00e+00	1499.00
IUUC-Cja-019357	Callithrix jacchus	96.85	0.00e+00	1479.00
IUUC-Cpo-022062	Cavia porcellus	96.16	0.00e+00	1468.00
IUUC-Csa-023517	Chlorocebus sabaeus	96.84	0.00e+00	1483.00
IUUC-Cho-025037	Choloepus hoffmanni	93.94	0.00e+00	973.00
IUUC-Cin-025580	Ciona intestinalis	40.66	3.00e-150	525.00
IUUC-Csv-025818	Ciona savignyi	40.55	8.00e-145	507.00
IUUC-Dre-027527	Danio rerio	70.56	0.00e+00	1075.00
IUUC-Dno-029475	Dasypus novemcinctus	85.06	0.00e+00	1132.00
IUUC-Dme-031698	Drosophila melanogaster	39.38	5.00e-133	468.00
IUUC-Ete-033090	Echinops telfairi	82.99	0.00e+00	1232.00
IUUC-Eca-033996	Equus caballus	96.02	0.00e+00	1476.00
IUUC-Eeu-035082	Erinaceus europaeus	87.66	0.00e+00	858.00
IUUC-Fca-035921	Felis catus	94.67	0.00e+00	1434.00
IUUC-Fal-037406	Ficedula albicollis	86.97	0.00e+00	1362.00
IUUC-Gmo-038721	Gadus morhua	70.77	0.00e+00	1049.00
IUUC-Gga-041234	Gallus gallus	86.15	0.00e+00	1351.00
IUUC-Gac-042315	Gasterosteus aculeatus	71.45	0.00e+00	1068.00
IUUC-Ggo-044885	Gorilla gorilla	90.26	0.00e+00	1364.00
IUUC-Hsa-046847	Homo sapiens	96.71	0.00e+00	1481.00
IUUC-Itr-047906	Ictidomys tridecemlineatus	96.05	0.00e+00	1466.00
IUUC-Lch-049731	Latimeria chalumnae	53.92	0.00e+00	769.00
IUUC-Loc-051879	Lepisosteus oculatus	73.08	0.00e+00	1109.00
IUUC-Laf-054232	Loxodonta africana	95.48	0.00e+00	1462.00
IUUC-Mcc-055447	Macaca mulatta	96.98	0.00e+00	1486.00
IUUC-Meu-056138	Macropus eugenii	96.98	0.00e+00	682.00
IUUC-Mga-059460	Meleagris gallopavo	84.95	0.00e+00	1324.00
IUUC-Mmr-061445	Microcebus murinus	96.98	0.00e+00	1481.00
IUUC-Mmu-064107	Mus musculus	93.42	0.00e+00	1425.00
IUUC-Mpu-066834	Mustela putorius furo	98.35	0.00e+00	1502.00
IUUC-Mlu-068006	Myotis lucifugus	93.84	0.00e+00	1412.00
IUUC-Nle-069280	Nomascus leucogenys	96.57	0.00e+00	1480.00
IUUC-Opr-070728	Ochotona princeps	88.36	0.00e+00	1189.00
IUUC-Ont-071621	Oreochromis niloticus	72.60	0.00e+00	1086.00
IUUC-Oan-073162	Ornithorhynchus anatinus	91.14	0.00e+00	1365.00
IUUC-Ocu-074787	Oryctolagus cuniculus	97.12	0.00e+00	1484.00
IUUC-Ola-086737	Oryzias latipes	33.48	4.00e-28	119.00
IUUC-Oga-088764	Otolemur garnettii	95.34	0.00e+00	1464.00
IUUC-Oar-090333	Ovis aries	97.67	0.00e+00	1492.00
IUUC-Ptr-090568	Pan troglodytes	96.43	0.00e+00	1477.00
IUUC-Pan-091979	Papio anubis	96.72	0.00e+00	1476.00
IUUC-Psi-093336	Pelodiscus sinensis	86.97	0.00e+00	1345.00
IUUC-Pma-094200	Petromyzon marinus	44.20	8.00e-176	610.00
IUUC-Pfo-096354	Poecilia formosa	71.41	0.00e+00	1077.00
IUUC-Pab-098499	Pongo abelii	96.84	0.00e+00	1481.00
IUUC-Pva-102454	Pteropus vampyrus	96.02	0.00e+00	1450.00
IUUC-Rno-105595	Rattus norvegicus	93.55	0.00e+00	1417.00
IUUC-Sha-106864	Sarcophilus harrisii	93.44	0.00e+00	1447.00
IUUC-Sar-113728	Sorex araneus	88.57	0.00e+00	1269.00
IUUC-Tgu-117200	Taeniopygia guttata	85.93	0.00e+00	1343.00
IUUC-Tsy-119017	Tarsius syrichta	95.59	0.00e+00	1089.00
IUUC-Tni-120724	Tetraodon nigroviridis	70.80	0.00e+00	1070.00
IUUC-Tbe-127887	Tupaia belangeri	86.69	0.00e+00	1035.00
IUUC-Ttr-129111	Tursiops truncatus	89.99	0.00e+00	1353.00
IUUC-Vpa-130724	Vicugna pacos	98.35	0.00e+00	1500.00
IUUC-Xtr-132091	Xenopus tropicalis	74.42	0.00e+00	1158.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence