iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040252

Ensembl Protein ID

ENSGALP00000016911.3

UniProt Accession

E1C3Q9; E1C3Q9_CHICK

Genbank Protein ID

ENSGALP00000016911

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AADN04000312

Gene Name

SIAH2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000010395.5	ENSGALT00000016930.5	ENSGALP00000016911.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	86.73	2.00e-151	532.00	IUUC-Hsa-046179
E3 activity/RING/RING	85.19	2.00e-151	531.00	IUUC-Mmu-063206
E3 activity/RING/RING	85.49	2.00e-151	531.00	IUUC-Rno-105477

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gallus gallus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRPSSAGPG ASKPCGKQPP PHASAPAAAA PAPAAATIAA SGAGSSAVPA AAAVLSGPGG 60
PVSPQHHELT SLFECPVCFD YVLPPILQCQ AGHLVCKQCR QKLSLCPTCR GSLTPSIRNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCGCC CGTCCTCCGC CGGGCCCGGC GCTAGCAAAC CCTGCGGCAA GCAGCCGCCG 60
CCGCACGCCT CCGCCCCGGC CGCCGCCGCG CCCGCTCCCG CCGCCGCCAC CATCGCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR001370--BIR_rpt
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

gga:429164

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001409	Ailuropoda melanoleuca	97.67	6.00e-152	529.00
IUUC-Ame-011678	Astyanax mexicanus	90.12	2.00e-138	484.00
IUUC-Bta-012750	Bos taurus	97.65	1.00e-150	525.00
IUUC-Cja-019800	Callithrix jacchus	89.81	3.00e-151	526.00
IUUC-Cfa-020505	Canis familiaris	97.65	3.00e-150	524.00
IUUC-Cpo-021394	Cavia porcellus	83.49	8.00e-152	529.00
IUUC-Csa-023374	Chlorocebus sabaeus	89.81	3.00e-151	526.00
IUUC-Cho-024933	Choloepus hoffmanni	97.65	3.00e-150	523.00
IUUC-Dre-027711	Danio rerio	89.72	8.00e-138	482.00
IUUC-Dno-029260	Dasypus novemcinctus	97.55	2.00e-144	504.00
IUUC-Dor-030489	Dipodomys ordii	95.14	1.00e-106	378.00
IUUC-Ete-032946	Echinops telfairi	86.11	2.00e-154	537.00
IUUC-Eca-033546	Equus caballus	96.93	6.00e-154	536.00
IUUC-Eeu-034861	Erinaceus europaeus	93.82	8.00e-146	509.00
IUUC-Fal-037160	Ficedula albicollis	88.84	8.00e-134	469.00
IUUC-Gmo-039091	Gadus morhua	88.93	4.00e-137	480.00
IUUC-Gac-041673	Gasterosteus aculeatus	88.54	4.00e-137	480.00
IUUC-Ggo-044618	Gorilla gorilla	89.81	3.00e-151	526.00
IUUC-Hsa-046179	Homo sapiens	89.81	3.00e-151	526.00
IUUC-Itr-048976	Ictidomys tridecemlineatus	96.90	1.00e-150	525.00
IUUC-Lch-049496	Latimeria chalumnae	82.08	8.00e-151	525.00
IUUC-Loc-052107	Lepisosteus oculatus	90.80	2.00e-138	484.00
IUUC-Laf-054257	Loxodonta africana	96.55	5.00e-151	526.00
IUUC-Mcc-055023	Macaca mulatta	89.81	3.00e-151	526.00
IUUC-Meu-055922	Macropus eugenii	96.08	6.00e-147	512.00
IUUC-Mga-060070	Meleagris gallopavo	95.17	2.00e-151	527.00
IUUC-Mmr-061494	Microcebus murinus	89.81	3.00e-151	526.00
IUUC-Mdo-061971	Monodelphis domestica	97.65	5.00e-150	523.00
IUUC-Mmu-063206	Mus musculus	97.64	9.00e-150	522.00
IUUC-Mpu-066597	Mustela putorius furo	89.81	3.00e-151	526.00
IUUC-Mlu-067199	Myotis lucifugus	97.25	8.00e-150	522.00
IUUC-Nle-069342	Nomascus leucogenys	89.81	3.00e-151	526.00
IUUC-Opr-070341	Ochotona princeps	56.21	2.00e-50	191.00
IUUC-Ont-071906	Oreochromis niloticus	86.31	2.00e-138	484.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.21	8.00e-50	189.00
IUUC-Ocu-073950	Oryctolagus cuniculus	97.68	4.00e-153	533.00
IUUC-Oga-089154	Otolemur garnettii	89.81	3.00e-151	526.00
IUUC-Oar-089446	Ovis aries	96.55	1.00e-152	531.00
IUUC-Ptr-091088	Pan troglodytes	89.81	3.00e-151	526.00
IUUC-Psi-093079	Pelodiscus sinensis	97.72	1.00e-154	538.00
IUUC-Pfo-097007	Poecilia formosa	84.58	5.00e-131	460.00
IUUC-Pab-098092	Pongo abelii	89.81	3.00e-151	526.00
IUUC-Pca-100328	Procavia capensis	87.65	2.00e-146	511.00
IUUC-Pva-102368	Pteropus vampyrus	98.21	4.00e-63	234.00
IUUC-Rno-105477	Rattus norvegicus	97.64	9.00e-150	522.00
IUUC-Sha-107630	Sarcophilus harrisii	97.72	1.00e-154	538.00
IUUC-Ssc-116441	Sus scrofa	89.81	2.00e-151	527.00
IUUC-Tru-118004	Takifugu rubripes	86.17	2.00e-132	464.00
IUUC-Tsy-119548	Tarsius syrichta	87.97	2.00e-66	244.00
IUUC-Tni-120846	Tetraodon nigroviridis	87.75	8.00e-135	472.00
IUUC-Vpa-130799	Vicugna pacos	98.27	2.00e-103	367.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence