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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063910
UUCD1 version UUC-MuM-01231
Ensembl Protein ID ENSMUSP00000087857.2
UniProt Accession P15975; A2RT25; Q8BR11; Q8CB37; Q8R251; UBP53_MOUSE
Genbank Protein ID BAC29614.1; BAC32545.1; AAH22221.1; AAI32340.1; AAI45708.1; CAA31296.1
Protein Name Inactive ubiquitin carboxyl-terminal hydrolase 53; Inactive ubiquitin-specific peptidase 53; Per-hexamer repeat protein 3; Protein mambo
Genbank Nucleotide ID AK036876; AK045953; BC022221; BC132339; BC145707; X12807
Gene Name Usp53; Phxr3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000039701.11 ENSMUST00000090379.6 ENSMUSP00000087857.2
ENSMUSG00000039701.11 ENSMUST00000199329.4 ENSMUSP00000143119.1
ENSMUSG00000039701.11 ENSMUST00000197934.4 ENSMUSP00000143412.1
ENSMUSG00000039701.11 ENSMUST00000197314.4 ENSMUSP00000142600.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.80e-23 84.4 31 349
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNl..gNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaee...fs 85
           Gl N   +N+C++NS++Q+L+++  +r+ l   + + ++ +      +++ ++l+++f+++++s++ka    ++ +al++  +    f+
   Q: 31   GLLNEpgQNSCFLNSAVQVLWQLDIFRRSLRALTGHICQGD------ACIFCALKTIFAQFQHSREKALPSDNIRHALAESFKDeqrFQ 113
           66665558************************777777764......7*************9999999999987777776543222399 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
                Da E+++ +l +++ +l                     +++ +  ++++++ ++ F ++l +q++c +c+ +s    pf++l  
   Q: 114  LGLMDDAAECFENILARIHFHL-------------------VPNRDADMCTSKSCVTHQKFAMTLYEQCVCRSCGASSDPL-PFTELVR 182
           **********************...................122356789999**********************999655.9999999 PP
   S: 175  pvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkve 254
            ++    +++             +++++  ++ +  ++ +   ++c +k + ++   l ++Pe+ ++ L +   se+ +  e + +++ 
   Q: 183  YISTTALCNEVermmerherVKPEMFAELLQAANTADDYRKCPSNCGQKIKIRRV--LMNCPEIVTIGLVWD--SEHSDLTEDVVRSLA 267
           9997666654466666666444477889999999988887788899988865544..6688**********9..444444444444444 PP
   S: 255  fpleLdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtev..keeevleetg...staYvlfYk 336
           + l L    + +++e  ++++ +  L+++++++      HY+a++ ++k + W+ fdD +V+e+  ++++v++++     ++ +lfY 
   Q: 268  THLYLPGLFYRVTDE--NATDSELHLVGMICYTS----RHYCAFAFHTKSSkWVFFDDAHVKEMgtRWKDVVSKCIrchLQPLLLFYA 349
           443332222333333..3348999********97....9********77767***********9656899999766888899999996 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (PubMed:26609154). Has no peptidase activity (PubMed:26609154).
 Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (PubMed:26609154). Has no peptidase activity (PubMed:26609154).
Protein Sequence
(Fasta)
MAWVKFLRKP SGNLGKAYQA GSLLSLAPTV GLLNEPGQNS CFLNSAVQVL WQLDIFRRSL 60
RALTGHICQG DACIFCALKT IFAQFQHSRE KALPSDNIRH ALAESFKDEQ RFQLGLMDDA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063910|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGGCGGGG TCCAGAGACC TGTTGATCGC AGGTGTCACT GCCCAGACCG GCCCCTGGGT 60
CTTGGGCGTG CGCGCATGCT CTGCGCGGGT CTGGCGGCTG AAAGCGGCGG TGTGGCCGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063910|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0796--Tight junction
Interpro

IPR001394--Peptidase_C19_UCH
IPR028889--USP_dom
PROSITE

PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0005911--C:cell-cell junction
GO:0001508--P:action potential
GO:0006915--P:apoptotic process
GO:0051402--P:neuron apoptotic process
GO:0010996--P:response to auditory stimulus
GO:0007605--P:sensory perception of sound
KEGG mmu:99526
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002136 Ailuropoda melanoleuca 74.10 0.00e+00 1527.00
IUUC-Apl-003843 Anas platyrhynchos 57.50 0.00e+00 1114.00
IUUC-Aca-004689 Anolis carolinensis 56.55 0.00e+00 1077.00
IUUC-Ame-010673 Astyanax mexicanus 69.61 0.00e+00 634.00
IUUC-Bta-012434 Bos taurus 72.34 0.00e+00 1510.00
IUUC-Cja-019625 Callithrix jacchus 72.34 0.00e+00 1524.00
IUUC-Cfa-020038 Canis familiaris 74.08 0.00e+00 1555.00
IUUC-Cpo-021503 Cavia porcellus 70.45 0.00e+00 1474.00
IUUC-Csa-024021 Chlorocebus sabaeus 72.90 0.00e+00 1531.00
IUUC-Cho-024769 Choloepus hoffmanni 77.36 0.00e+00 1131.00
IUUC-Dre-028438 Danio rerio 70.24 0.00e+00 631.00
IUUC-Dno-029317 Dasypus novemcinctus 71.36 0.00e+00 1449.00
IUUC-Dor-030249 Dipodomys ordii 93.37 0.00e+00 778.00
IUUC-Ete-032403 Echinops telfairi 69.25 0.00e+00 1437.00
IUUC-Eca-033216 Equus caballus 73.66 0.00e+00 1524.00
IUUC-Eeu-035319 Erinaceus europaeus 61.51 2.00e-161 563.00
IUUC-Fca-036414 Felis catus 74.82 0.00e+00 1553.00
IUUC-Fal-036886 Ficedula albicollis 55.84 0.00e+00 1126.00
IUUC-Gmo-039688 Gadus morhua 75.28 3.00e-158 551.00
IUUC-Gga-040930 Gallus gallus 56.86 0.00e+00 1148.00
IUUC-Gac-041515 Gasterosteus aculeatus 76.68 7.00e-169 586.00
IUUC-Ggo-045573 Gorilla gorilla 73.54 0.00e+00 1548.00
IUUC-Hsa-046741 Homo sapiens 73.64 0.00e+00 1545.00
IUUC-Itr-048229 Ictidomys tridecemlineatus 61.57 0.00e+00 1202.00
IUUC-Lch-049932 Latimeria chalumnae 61.81 0.00e+00 844.00
IUUC-Loc-052180 Lepisosteus oculatus 59.21 0.00e+00 833.00
IUUC-Laf-054545 Loxodonta africana 74.43 0.00e+00 1580.00
IUUC-Mcc-054918 Macaca mulatta 73.64 0.00e+00 1552.00
IUUC-Meu-056802 Macropus eugenii 59.28 0.00e+00 942.00
IUUC-Mga-059684 Meleagris gallopavo 56.18 0.00e+00 1098.00
IUUC-Mmr-060991 Microcebus murinus 70.31 0.00e+00 1219.00
IUUC-Mdo-062636 Monodelphis domestica 58.60 0.00e+00 1123.00
IUUC-Mpu-065796 Mustela putorius furo 69.64 0.00e+00 1388.00
IUUC-Nle-069276 Nomascus leucogenys 72.71 0.00e+00 1474.00
IUUC-Opr-070545 Ochotona princeps 66.72 0.00e+00 763.00
IUUC-Ont-072449 Oreochromis niloticus 54.09 0.00e+00 687.00
IUUC-Oan-073493 Ornithorhynchus anatinus 53.88 0.00e+00 885.00
IUUC-Ocu-074445 Oryctolagus cuniculus 71.92 0.00e+00 1521.00
IUUC-Ola-087574 Oryzias latipes 69.08 1.00e-163 568.00
IUUC-Oga-087977 Otolemur garnettii 72.75 0.00e+00 1451.00
IUUC-Oar-089584 Ovis aries 72.66 0.00e+00 1510.00
IUUC-Ptr-091610 Pan troglodytes 73.27 0.00e+00 1521.00
IUUC-Pan-091828 Papio anubis 70.15 0.00e+00 1422.00
IUUC-Psi-093643 Pelodiscus sinensis 59.67 0.00e+00 1219.00
IUUC-Pfo-096829 Poecilia formosa 62.17 1.00e-178 620.00
IUUC-Pab-098190 Pongo abelii 73.08 0.00e+00 1512.00
IUUC-Pca-100356 Procavia capensis 59.17 0.00e+00 634.00
IUUC-Pva-102372 Pteropus vampyrus 68.42 0.00e+00 1368.00
IUUC-Rno-105609 Rattus norvegicus 85.11 0.00e+00 1130.00
IUUC-Sha-107092 Sarcophilus harrisii 59.43 0.00e+00 1194.00
IUUC-Sar-113376 Sorex araneus 64.75 0.00e+00 722.00
IUUC-Ssc-115969 Sus scrofa 73.60 0.00e+00 1486.00
IUUC-Tgu-117134 Taeniopygia guttata 70.69 0.00e+00 1048.00
IUUC-Tru-117981 Takifugu rubripes 67.69 5.00e-166 577.00
IUUC-Tsy-119297 Tarsius syrichta 65.80 0.00e+00 1281.00
IUUC-Tni-120116 Tetraodon nigroviridis 75.55 2.00e-168 584.00
IUUC-Tbe-127607 Tupaia belangeri 72.05 0.00e+00 1447.00
IUUC-Ttr-128647 Tursiops truncatus 73.94 0.00e+00 1409.00
IUUC-Vpa-130288 Vicugna pacos 71.13 0.00e+00 1484.00
Created Date 25-Jun-2017

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