iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132057

Ensembl Protein ID

ENSXETP00000040254.3

UniProt Accession

F6TDJ6; F6TDJ6_XENTR

Genbank Protein ID

ENSXETP00000040254

Protein Name

Protein HIRA

Genbank Nucleotide ID

AAMC01006242

Gene Name

hira

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000018598.3	ENSXETT00000040254.3	ENSXETP00000040254.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-18	65.3	69	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 69   HLACVNCVRWsNSgAYLASGGDDKLIMVWK 98
           8899******95569**************7 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

Protein Sequence
(Fasta)

MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMPPLLK EEDEKNENIP 60
KMLCQMDNHL ACVNCVRWSN SGAYLASGGD DKLIMVWKRS GYIGPSTVFG SSSKLANVEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGCTCC TGAAACCAAC CTGGGTTAAT CATAATGGTG AGGGAGGAAA GGTCCCCGGG 60
GGCTGAGGGA GTTAGAGGCG CTTTTAAGTC AATTCTAGTT ATCGCAGGGA ACTGCTACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0000790--C:nuclear chromatin
GO:0031491--F:nucleosome binding
GO:0003714--F:transcription corepressor activity
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0031935--P:regulation of chromatin silencing
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001039	Aegilops tauschii	39.10	6.00e-88	319.00
IUUC-Aml-001723	Ailuropoda melanoleuca	81.55	0.00e+00	932.00
IUUC-Atr-003132	Amborella trichopoda	35.59	7.00e-89	322.00
IUUC-Apl-003197	Anas platyrhynchos	75.20	0.00e+00	1436.00
IUUC-Aca-004733	Anolis carolinensis	82.03	0.00e+00	979.00
IUUC-Aly-005446	Arabidopsis lyrata	39.49	8.00e-81	295.00
IUUC-Ath-007627	Arabidopsis thaliana	40.71	5.00e-84	306.00
IUUC-Ago-007766	Ashbya gossypii	30.22	2.00e-59	223.00
IUUC-Acl-008104	Aspergillus clavatus	30.42	7.00e-66	245.00
IUUC-Afl-008591	Aspergillus flavus	32.29	1.00e-62	234.00
IUUC-Afu-008781	Aspergillus fumigatus	31.45	1.00e-58	221.00
IUUC-Ani-009272	Aspergillus nidulans	28.91	6.00e-55	209.00
IUUC-Ang-009655	Aspergillus niger	32.59	3.00e-64	240.00
IUUC-Aor-010119	Aspergillus oryzae	29.45	5.00e-63	236.00
IUUC-Ate-010530	Aspergillus terreus	26.99	2.00e-55	210.00
IUUC-Ame-011147	Astyanax mexicanus	84.16	1.00e-52	196.00
IUUC-Bgr-012237	Blumeria graminis	33.58	1.00e-62	235.00
IUUC-Bta-013320	Bos taurus	73.33	0.00e+00	1427.00
IUUC-Bci-013795	Botrytis cinerea	28.53	3.00e-68	253.00
IUUC-Bdi-014075	Brachypodium distachyon	37.08	2.00e-92	334.00
IUUC-Bol-016440	Brassica oleracea	35.70	2.00e-86	313.00
IUUC-Bra-016651	Brassica rapa	40.10	7.00e-86	311.00
IUUC-Cel-018692	Caenorhabditis elegans	37.83	2.00e-75	277.00
IUUC-Cja-018987	Callithrix jacchus	80.47	0.00e+00	865.00
IUUC-Cfa-020132	Canis familiaris	80.07	0.00e+00	931.00
IUUC-Cpo-021484	Cavia porcellus	82.60	0.00e+00	957.00
IUUC-Cre-022846	Chlamydomonas reinhardtii	34.55	2.00e-60	228.00
IUUC-Csa-023081	Chlorocebus sabaeus	82.09	0.00e+00	961.00
IUUC-Cin-025182	Ciona intestinalis	55.51	2.00e-158	553.00
IUUC-Csv-026154	Ciona savignyi	56.06	3.00e-157	548.00
IUUC-Cgl-026655	Colletotrichum gloeosporioides	30.30	3.00e-68	253.00
IUUC-Cne-026891	Cryptococcus neoformans	40.97	1.00e-83	304.00
IUUC-Cme-027349	Cyanidioschyzon merolae	29.24	2.00e-52	201.00
IUUC-Dre-027655	Danio rerio	67.39	0.00e+00	1339.00
IUUC-Dno-029557	Dasypus novemcinctus	74.56	0.00e+00	815.00
IUUC-Dor-030687	Dipodomys ordii	75.05	0.00e+00	690.00
IUUC-Dse-031334	Dothistroma septosporum	30.78	4.00e-64	239.00
IUUC-Dme-031746	Drosophila melanogaster	55.30	4.00e-158	551.00
IUUC-Ete-032384	Echinops telfairi	70.48	0.00e+00	1296.00
IUUC-Eca-033430	Equus caballus	81.03	0.00e+00	917.00
IUUC-Fca-036121	Felis catus	80.55	0.00e+00	932.00
IUUC-Fal-036817	Ficedula albicollis	75.79	0.00e+00	1438.00
IUUC-Fox-037906	Fusarium oxysporum	34.09	7.00e-67	248.00
IUUC-Fso-038409	Fusarium solani	33.25	1.00e-66	248.00
IUUC-Gmo-039151	Gadus morhua	85.18	0.00e+00	700.00
IUUC-Ggr-040016	Gaeumannomyces graminis	34.74	2.00e-69	257.00
IUUC-Gga-040936	Gallus gallus	76.12	0.00e+00	1525.00
IUUC-Gac-041405	Gasterosteus aculeatus	69.57	0.00e+00	780.00
IUUC-Gma-044252	Glycine max	35.71	4.00e-89	322.00
IUUC-Ggo-045430	Gorilla gorilla	81.76	0.00e+00	959.00
IUUC-Hsa-046442	Homo sapiens	81.93	0.00e+00	961.00
IUUC-Hvu-047587	Hordeum vulgare	39.94	6.00e-78	285.00
IUUC-Itr-048910	Ictidomys tridecemlineatus	93.00	8.00e-166	575.00
IUUC-Kpa-049145	Komagataella pastoris	30.44	3.00e-59	223.00
IUUC-Lch-050474	Latimeria chalumnae	71.10	0.00e+00	1357.00
IUUC-Lpe-051209	Leersia perrieri	35.96	5.00e-84	305.00
IUUC-Loc-052119	Lepisosteus oculatus	69.15	0.00e+00	1338.00
IUUC-Lma-053237	Leptosphaeria maculans	32.09	6.00e-66	246.00
IUUC-Laf-053718	Loxodonta africana	75.68	0.00e+00	1439.00
IUUC-Mcc-055621	Macaca mulatta	80.87	0.00e+00	867.00
IUUC-Meu-055914	Macropus eugenii	67.90	0.00e+00	1249.00
IUUC-Mor-057090	Magnaporthe oryzae	32.78	7.00e-67	249.00
IUUC-Mpo-057364	Magnaporthe poae	34.99	1.00e-70	261.00
IUUC-Mtr-057744	Medicago truncatula	37.08	2.00e-91	330.00
IUUC-Mla-058914	Melampsora laricipopulina	35.54	4.00e-88	319.00
IUUC-Mga-060181	Meleagris gallopavo	74.53	0.00e+00	1475.00
IUUC-Mvi-060432	Microbotryum violaceum	36.92	1.00e-73	271.00
IUUC-Mmr-060871	Microcebus murinus	75.91	0.00e+00	1464.00
IUUC-Mdo-062301	Monodelphis domestica	75.34	0.00e+00	1444.00
IUUC-Mmu-063888	Mus musculus	75.66	0.00e+00	1449.00
IUUC-Mac-065137	Musa acuminata	37.34	4.00e-89	322.00
IUUC-Mpu-066732	Mustela putorius furo	82.24	0.00e+00	947.00
IUUC-Mlu-067542	Myotis lucifugus	80.37	0.00e+00	915.00
IUUC-Nfi-068396	Neosartorya fischeri	31.52	1.00e-58	221.00
IUUC-Ncr-068842	Neurospora crassa	32.86	7.00e-69	255.00
IUUC-Nle-070156	Nomascus leucogenys	81.93	0.00e+00	959.00
IUUC-Opr-070808	Ochotona princeps	79.13	0.00e+00	662.00
IUUC-Ont-072105	Oreochromis niloticus	65.89	0.00e+00	1307.00
IUUC-Ocu-074962	Oryctolagus cuniculus	81.55	0.00e+00	942.00
IUUC-Oba-075178	Oryza barthii	35.71	2.00e-90	327.00
IUUC-Obr-076399	Oryza brachyantha	35.44	6.00e-92	332.00
IUUC-Ogu-078797	Oryza glumaepatula	35.71	2.00e-90	327.00
IUUC-Oin-080085	Oryza indica	33.97	2.00e-77	283.00
IUUC-Olo-081048	Oryza longistaminata	40.39	1.00e-66	248.00
IUUC-Ome-081324	Oryza meridionalis	35.71	2.00e-90	327.00
IUUC-Oni-082548	Oryza nivara	35.71	2.00e-90	327.00
IUUC-Opu-084008	Oryza punctata	41.33	1.00e-90	327.00
IUUC-Oru-084339	Oryza rufipogon	35.52	6.00e-90	325.00
IUUC-Osa-085782	Oryza sativa	35.52	6.00e-90	325.00
IUUC-Ola-087302	Oryzias latipes	69.44	0.00e+00	798.00
IUUC-Olu-087611	Ostreococcus lucimarinus	35.76	2.00e-88	320.00
IUUC-Oga-087935	Otolemur garnettii	81.58	0.00e+00	931.00
IUUC-Oar-089229	Ovis aries	70.71	0.00e+00	773.00
IUUC-Ptr-090715	Pan troglodytes	81.93	0.00e+00	961.00
IUUC-Pan-092318	Papio anubis	81.72	0.00e+00	934.00
IUUC-Psi-094053	Pelodiscus sinensis	74.85	0.00e+00	1477.00
IUUC-Pno-094985	Phaeosphaeria nodorum	32.93	1.00e-58	221.00
IUUC-Ppa-095819	Physcomitrella patens	35.05	3.00e-89	323.00
IUUC-Pfo-096857	Poecilia formosa	64.88	0.00e+00	1263.00
IUUC-Pab-098047	Pongo abelii	81.93	0.00e+00	960.00
IUUC-Pop-099865	Populus trichocarpa	37.42	2.00e-89	324.00
IUUC-Pca-100558	Procavia capensis	77.13	2.00e-147	516.00
IUUC-Ppe-101261	Prunus persica	36.73	5.00e-90	325.00
IUUC-Pva-102683	Pteropus vampyrus	74.56	0.00e+00	1445.00
IUUC-Pgr-103660	Puccinia graminis	34.80	5.00e-79	289.00
IUUC-Ptt-103900	Puccinia triticina	35.77	5.00e-81	295.00
IUUC-Pte-104209	Pyrenophora teres	32.21	2.00e-66	247.00
IUUC-Pyt-104802	Pyrenophora triticirepentis	34.26	1.00e-65	245.00
IUUC-Rno-105566	Rattus norvegicus	75.66	0.00e+00	1460.00
IUUC-Sce-106291	Saccharomyces cerevisiae	29.75	6.00e-61	229.00
IUUC-Sha-107514	Sarcophilus harrisii	70.81	0.00e+00	1305.00
IUUC-Sja-107833	Schizosaccharomyces japonicus	40.43	3.00e-80	293.00
IUUC-Spo-108162	Schizosaccharomyces pombe	38.89	3.00e-77	283.00
IUUC-Smo-109186	Selaginella moellendorffii	35.25	2.00e-89	323.00
IUUC-Sit-110730	Setaria italica	38.58	2.00e-93	337.00
IUUC-Sly-111547	Solanum lycopersicum	37.07	8.00e-91	328.00
IUUC-Stu-112705	Solanum tuberosum	37.07	3.00e-91	330.00
IUUC-Sar-113222	Sorex araneus	78.24	0.00e+00	892.00
IUUC-Sbi-114272	Sorghum bicolor	38.54	6.00e-95	342.00
IUUC-Sre-115061	Sporisorium reilianum	34.58	3.00e-77	283.00
IUUC-Ssc-116364	Sus scrofa	74.70	0.00e+00	1463.00
IUUC-Tgu-116645	Taeniopygia guttata	76.09	0.00e+00	1459.00
IUUC-Tru-117590	Takifugu rubripes	62.92	0.00e+00	1256.00
IUUC-Tsy-119212	Tarsius syrichta	75.43	0.00e+00	837.00
IUUC-Tni-119915	Tetraodon nigroviridis	64.79	0.00e+00	1256.00
IUUC-Tca-121765	Theobroma cacao	35.56	5.00e-89	322.00
IUUC-Tre-121887	Trichoderma reesei	33.08	8.00e-59	222.00
IUUC-Tvi-122262	Trichoderma virens	33.08	5.00e-59	223.00
IUUC-Tae-123009	Triticum aestivum	47.74	1.00e-36	148.00
IUUC-Tur-126483	Triticum urartu	42.35	5.00e-92	332.00
IUUC-Tme-127202	Tuber melanosporum	32.28	3.00e-56	213.00
IUUC-Tbe-127350	Tupaia belangeri	73.90	9.00e-167	580.00
IUUC-Ttr-129077	Tursiops truncatus	72.00	0.00e+00	1409.00
IUUC-Uma-129465	Ustilago maydis	34.44	2.00e-79	290.00
IUUC-Vda-129844	Verticillium dahliae	34.91	2.00e-66	248.00
IUUC-Vvi-131397	Vitis vinifera	35.90	4.00e-90	326.00
IUUC-Xma-134139	Xiphophorus maculatus	63.58	0.00e+00	757.00
IUUC-Yli-134424	Yarrowia lipolytica	31.62	4.00e-65	243.00
IUUC-Zma-135839	Zea mays	37.99	7.00e-93	335.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence