iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-067818

Ensembl Protein ID

ENSMLUP00000000142.2

UniProt Accession

G1NSM6; G1NSM6_MYOLU

Genbank Protein ID

ENSMLUP00000000142

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02052911

Gene Name

VAV1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000000153.2	ENSMLUT00000000155.2	ENSMLUP00000000142.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-21	75.7	792	843

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +v yd+ a +  eL+lk+Gd+v+++ +++  +gW++g  e  g+ G fP+n+ve+
   Q: 792  KVRYDFCARDRSELNLKEGDIVKIL-NKKGQQGWWRG--EIYGRIGWFPSNYVEE 843
           788**********************.89999******..9*************86 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL QPHAINLREV 60
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCTGT GGCGACAGTG TACCCACTGG CTGATCCAGT GCCGGGTGCT GCCGCCCAGC 60
CACCGCGTGA CCTGGGACGG GGCCCAGGTG TGCGAGCTGG CGCAAGCCCT GCGGGATGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR003096--SM22_calponin
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	81.60	0.00e+00	1254.00
IUUC-Cja-020009	Callithrix jacchus	92.58	0.00e+00	1600.00
IUUC-Cfa-020768	Canis familiaris	93.78	0.00e+00	1565.00
IUUC-Cin-025115	Ciona intestinalis	37.86	1.00e-136	480.00
IUUC-Csv-025995	Ciona savignyi	36.53	1.00e-143	503.00
IUUC-Dno-029602	Dasypus novemcinctus	92.37	0.00e+00	1559.00
IUUC-Eca-033682	Equus caballus	93.43	0.00e+00	1570.00
IUUC-Fca-035629	Felis catus	92.97	0.00e+00	1622.00
IUUC-Gmo-039693	Gadus morhua	59.27	0.00e+00	969.00
IUUC-Gac-041567	Gasterosteus aculeatus	65.15	0.00e+00	1011.00
IUUC-Hsa-045886	Homo sapiens	92.70	0.00e+00	1599.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	87.88	0.00e+00	1456.00
IUUC-Loc-051761	Lepisosteus oculatus	70.26	0.00e+00	1179.00
IUUC-Laf-054537	Loxodonta africana	92.84	0.00e+00	1567.00
IUUC-Mcc-054726	Macaca mulatta	92.34	0.00e+00	1597.00
IUUC-Mmr-060980	Microcebus murinus	91.57	0.00e+00	1560.00
IUUC-Mdo-061926	Monodelphis domestica	84.71	0.00e+00	1299.00
IUUC-Mmu-063942	Mus musculus	91.17	0.00e+00	1540.00
IUUC-Mpu-066000	Mustela putorius furo	93.08	0.00e+00	1556.00
IUUC-Ont-072213	Oreochromis niloticus	65.58	0.00e+00	1096.00
IUUC-Ocu-074830	Oryctolagus cuniculus	78.43	0.00e+00	1188.00
IUUC-Ola-087345	Oryzias latipes	62.68	0.00e+00	1041.00
IUUC-Oga-089104	Otolemur garnettii	93.31	0.00e+00	1576.00
IUUC-Oar-089459	Ovis aries	92.14	0.00e+00	1572.00
IUUC-Ptr-090766	Pan troglodytes	92.19	0.00e+00	1478.00
IUUC-Pan-091994	Papio anubis	91.65	0.00e+00	1580.00
IUUC-Psi-093595	Pelodiscus sinensis	77.09	0.00e+00	1264.00
IUUC-Pfo-097210	Poecilia formosa	65.50	0.00e+00	1077.00
IUUC-Pab-098630	Pongo abelii	92.68	0.00e+00	1564.00
IUUC-Pva-102406	Pteropus vampyrus	93.64	0.00e+00	1529.00
IUUC-Rno-105763	Rattus norvegicus	87.87	0.00e+00	1473.00
IUUC-Sha-106683	Sarcophilus harrisii	84.88	0.00e+00	1494.00
IUUC-Sar-113457	Sorex araneus	80.10	0.00e+00	943.00
IUUC-Ssc-115338	Sus scrofa	93.38	0.00e+00	1491.00
IUUC-Tru-118199	Takifugu rubripes	63.23	0.00e+00	1013.00
IUUC-Tni-120548	Tetraodon nigroviridis	63.80	0.00e+00	1036.00
IUUC-Tbe-127235	Tupaia belangeri	70.12	5.00e-133	468.00
IUUC-Vpa-130066	Vicugna pacos	71.23	6.00e-53	202.00
IUUC-Xtr-132410	Xenopus tropicalis	70.49	0.00e+00	1208.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence