iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000055547.1	ENSRNOT00000086127.1	ENSRNOP00000075137.1
ENSRNOG00000055547.1	ENSRNOT00000077423.1	ENSRNOP00000074053.1
ENSRNOG00000055547.1	ENSRNOT00000089439.1	ENSRNOP00000070559.1
ENSRNOG00000055547.1	ENSRNOT00000090521.1	ENSRNOP00000071167.1

Annotation

Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	12826399; 20064468

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	3.30e-23	81.8	2	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 3    ltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           ++v+++++  f++ev++d+++ +lKe +ak++gvp++q+++I+aGk+L+++ t+++++++++s+vh+v+++++
   Q: 2    VFVRFNSSYGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELQNHLTVQNCDLEQQSIVHIVQRPQR 74
           79*******************************************************************9986 PP

Organism

Rattus norvegicus

Functional Description
(View)

Functional Description

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30. Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains following mitochondrial damage, leading to mitophagy. Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

Protein Sequence
(Fasta)

LVFVRFNSSY GFPVEVDSDT SIFQLKEVVA KRQGVPADQL RVIFAGKELQ NHLTVQNCDL 60
EQQSIVHIVQ RPQRKSHETN ASGGDKPQST PEGSIWEPRS LTRVDLSSHI LPADSVGLAV 120

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Nucleotide Sequence
(Fasta)

CTAGTGTTTG TCAGGTTCAA CTCCAGCTAT GGCTTCCCAG TGGAGGTCGA TTCTGACACC 60
AGCATCTTCC AGCTCAAGGA AGTGGTTGCT AAGCGACAGG GGGTTCCAGC TGACCAGCTG 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005622--C:intracellular
GO:0045121--C:membrane raft
GO:0005739--C:mitochondrion
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0045202--C:synapse
GO:0008021--C:synaptic vesicle
GO:0030672--C:synaptic vesicle membrane
GO:0043195--C:terminal bouton
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:1990444--F:F-box domain binding
GO:0001664--F:G-protein coupled receptor binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0030165--F:PDZ domain binding
GO:0032403--F:protein complex binding
GO:0019901--F:protein kinase binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0043130--F:ubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008344--P:adult locomotory behavior
GO:0070842--P:aggresome assembly
GO:0006464--P:cellular protein modification process
GO:0071287--P:cellular response to manganese ion
GO:0097237--P:cellular response to toxic substance
GO:0000266--P:mitochondrial fission
GO:0051646--P:mitochondrion localization
GO:0007005--P:mitochondrion organization
GO:0000422--P:mitophagy
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0090394--P:negative regulation of excitatory postsynaptic potential
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion
GO:0046329--P:negative regulation of JNK cascade
GO:0090258--P:negative regulation of mitochondrial fission
GO:0010637--P:negative regulation of mitochondrial fusion
GO:0043524--P:negative regulation of neuron apoptotic process
GO:1901215--P:negative regulation of neuron death
GO:1903204--P:negative regulation of oxidative stress-induced neuron death
GO:1903377--P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:0001933--P:negative regulation of protein phosphorylation
GO:1903427--P:negative regulation of reactive oxygen species biosynthetic process
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:0051967--P:negative regulation of synaptic transmission, glutamatergic
GO:0070050--P:neuron cellular homeostasis
GO:0042551--P:neuron maturation
GO:2001171--P:positive regulation of ATP biosynthetic process
GO:0043388--P:positive regulation of DNA binding
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0035774--P:positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0090141--P:positive regulation of mitochondrial fission
GO:0010636--P:positive regulation of mitochondrial fusion
GO:0010918--P:positive regulation of mitochondrial membrane potential
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0010506--P:regulation of autophagy
GO:1900407--P:regulation of cellular response to oxidative stress
GO:0010821--P:regulation of mitochondrion organization
GO:0051412--P:response to corticosterone
GO:0042493--P:response to drug
GO:0034976--P:response to endoplasmic reticulum stress
GO:0006979--P:response to oxidative stress
GO:0006986--P:response to unfolded protein
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0055069--P:zinc ion homeostasis

KEGG

rno:56816

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	78.82	4.00e-133	467.00
IUUC-Apl-003304	Anas platyrhynchos	75.17	2.00e-67	248.00
IUUC-Ame-011856	Astyanax mexicanus	59.17	9.00e-92	330.00
IUUC-Bta-013014	Bos taurus	78.47	3.00e-131	461.00
IUUC-Cel-018687	Caenorhabditis elegans	26.14	1.00e-17	84.00
IUUC-Cja-019274	Callithrix jacchus	81.60	2.00e-139	488.00
IUUC-Cfa-020461	Canis familiaris	77.78	3.00e-132	464.00
IUUC-Cpo-022251	Cavia porcellus	82.01	2.00e-142	498.00
IUUC-Csa-023112	Chlorocebus sabaeus	81.25	1.00e-130	459.00
IUUC-Cho-024504	Choloepus hoffmanni	60.58	6.00e-75	274.00
IUUC-Dre-028202	Danio rerio	57.09	1.00e-90	327.00
IUUC-Dor-030508	Dipodomys ordii	68.75	2.00e-101	362.00
IUUC-Dme-031980	Drosophila melanogaster	37.09	3.00e-49	189.00
IUUC-Ete-032281	Echinops telfairi	71.81	1.00e-62	233.00
IUUC-Eca-033228	Equus caballus	79.58	5.00e-136	476.00
IUUC-Fca-036045	Felis catus	61.54	2.00e-19	86.30
IUUC-Fal-037507	Ficedula albicollis	66.78	2.00e-110	392.00
IUUC-Gmo-038744	Gadus morhua	66.67	7.00e-42	164.00
IUUC-Gga-040353	Gallus gallus	66.33	1.00e-105	376.00
IUUC-Gac-042519	Gasterosteus aculeatus	45.79	1.00e-67	250.00
IUUC-Hsa-046016	Homo sapiens	81.31	9.00e-138	483.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	84.03	1.00e-140	492.00
IUUC-Loc-052389	Lepisosteus oculatus	63.57	3.00e-99	355.00
IUUC-Laf-053412	Loxodonta africana	62.22	1.00e-24	103.00
IUUC-Mcc-054933	Macaca mulatta	81.31	5.00e-138	484.00
IUUC-Meu-055963	Macropus eugenii	52.36	2.00e-60	226.00
IUUC-Mmr-061430	Microcebus murinus	92.16	1.00e-22	97.40
IUUC-Mmu-063561	Mus musculus	93.43	3.00e-160	558.00
IUUC-Mpu-065799	Mustela putorius furo	77.78	8.00e-129	452.00
IUUC-Mlu-068134	Myotis lucifugus	76.39	2.00e-125	441.00
IUUC-Nle-070078	Nomascus leucogenys	81.94	1.00e-139	488.00
IUUC-Opr-070541	Ochotona princeps	80.49	2.00e-134	472.00
IUUC-Ont-071743	Oreochromis niloticus	50.85	2.00e-68	253.00
IUUC-Oan-073700	Ornithorhynchus anatinus	85.19	2.00e-22	96.30
IUUC-Oga-088867	Otolemur garnettii	83.33	1.00e-138	486.00
IUUC-Oar-089365	Ovis aries	77.78	2.00e-129	455.00
IUUC-Ptr-091371	Pan troglodytes	80.62	3.00e-136	478.00
IUUC-Pan-092443	Papio anubis	81.60	3.00e-138	484.00
IUUC-Psi-093851	Pelodiscus sinensis	62.18	6.00e-85	306.00
IUUC-Pfo-097194	Poecilia formosa	48.61	2.00e-71	263.00
IUUC-Pab-097999	Pongo abelii	70.59	2.00e-111	395.00
IUUC-Pca-100410	Procavia capensis	75.61	6.00e-127	447.00
IUUC-Pva-102300	Pteropus vampyrus	63.41	3.00e-96	345.00
IUUC-Sha-106992	Sarcophilus harrisii	90.74	7.00e-24	101.00
IUUC-Sar-113121	Sorex araneus	90.74	7.00e-22	97.80
IUUC-Ssc-116435	Sus scrofa	77.43	4.00e-129	453.00
IUUC-Tgu-117489	Taeniopygia guttata	66.67	2.00e-111	395.00
IUUC-Tru-117927	Takifugu rubripes	48.89	7.00e-76	278.00
IUUC-Tsy-119372	Tarsius syrichta	85.53	3.00e-77	282.00
IUUC-Tni-120043	Tetraodon nigroviridis	45.13	1.00e-64	240.00
IUUC-Tbe-127539	Tupaia belangeri	81.88	2.00e-137	481.00
IUUC-Ttr-129149	Tursiops truncatus	74.39	2.00e-123	436.00
IUUC-Vpa-130439	Vicugna pacos	55.86	1.00e-80	293.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence