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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064201
Ensembl Protein ID ENSMUSP00000103056.1
UniProt Accession Q64321; Q80VV5; ZBT7B_MOUSE
Genbank Protein ID AAH46533.1; AAA61956.1; CAA85307.1
Protein Name Zinc finger and BTB domain-containing protein 7B; Krueppel-related zinc finger protein cKrox; T-helper-inducing POZ/Krueppel-like factor; Zinc finger protein 67; Zinc finger protein Th-POK
Genbank Nucleotide ID BC046533; L35307; Z36549
Gene Name Zbtb7b; Thpok; Zfp67
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028042.15 ENSMUST00000107433.7 ENSMUSP00000103056.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsiteJASPARmiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.20e-09 39.5 34 112
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees..............ksklmveikdvqpevfrallkFlYtgkld 66
           +D ++  +g e+++h++vLaa+S++F++lf+ +   +                 +  e++ v pe++ all+F Yt +l+
   Q: 34   CDLTIRTQGLEYRTHRAVLAACSHYFKKLFTEGGGGTvmgtggggtasggaG-AGVCELDFVGPEALGALLEFAYTATLT 112
           89****************************77776557899*******9854.88888888***************9986 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes.
 Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes.
Protein Sequence
(Fasta)
MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA VLAACSHYFK 60
KLFTEGGGGT VMGTGGGGTA SGGAGAGVCE LDFVGPEALG ALLEFAYTAT LTTSSANMPA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064201|E3,BTB_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
GGGGATCCCG GGTCAGCCCG GGTGAGGGCC AGGGCCCCCC TGGCACCGCC CATTGTGGTC 60
CAACAGGTTG AGCTGGTGTC CTGCGGAGCC ACCTGCTGGA AAGGGAAGGA GGCCCCCTGC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064201|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0042803--F:protein homodimerization activity
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0010628--P:positive regulation of gene expression
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043370--P:regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043376--P:regulation of CD8-positive, alpha-beta T cell differentiation
KEGG mmu:22724
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aca-005247 Anolis carolinensis 56.19 7.00e-50 191.00
IUUC-Ame-010706 Astyanax mexicanus 85.25 2.00e-61 229.00
IUUC-Bta-013174 Bos taurus 87.32 0.00e+00 736.00
IUUC-Cja-019527 Callithrix jacchus 90.07 0.00e+00 731.00
IUUC-Cfa-021183 Canis familiaris 89.91 0.00e+00 783.00
IUUC-Cpo-021564 Cavia porcellus 91.19 0.00e+00 751.00
IUUC-Csa-024245 Chlorocebus sabaeus 90.62 0.00e+00 733.00
IUUC-Dre-028292 Danio rerio 84.17 1.00e-60 227.00
IUUC-Dno-028864 Dasypus novemcinctus 88.60 0.00e+00 704.00
IUUC-Dor-031131 Dipodomys ordii 88.81 0.00e+00 744.00
IUUC-Eca-033561 Equus caballus 80.00 0.00e+00 649.00
IUUC-Eeu-035040 Erinaceus europaeus 75.34 3.00e-92 331.00
IUUC-Fal-036849 Ficedula albicollis 79.61 1.00e-90 326.00
IUUC-Gmo-038776 Gadus morhua 81.30 1.00e-58 219.00
IUUC-Gga-040853 Gallus gallus 89.04 8.00e-77 280.00
IUUC-Gac-041877 Gasterosteus aculeatus 83.46 2.00e-63 236.00
IUUC-Ggo-044434 Gorilla gorilla 90.44 0.00e+00 726.00
IUUC-Hsa-046812 Homo sapiens 90.44 0.00e+00 724.00
IUUC-Itr-048180 Ictidomys tridecemlineatus 90.99 0.00e+00 770.00
IUUC-Lch-049665 Latimeria chalumnae 52.82 4.00e-120 424.00
IUUC-Mcc-055723 Macaca mulatta 90.62 0.00e+00 712.00
IUUC-Meu-056152 Macropus eugenii 77.32 8.00e-137 479.00
IUUC-Mmr-061549 Microcebus murinus 91.54 0.00e+00 800.00
IUUC-Mdo-061946 Monodelphis domestica 78.49 0.00e+00 679.00
IUUC-Mpu-066752 Mustela putorius furo 84.59 0.00e+00 751.00
IUUC-Nle-069749 Nomascus leucogenys 90.62 0.00e+00 732.00
IUUC-Ocu-074243 Oryctolagus cuniculus 87.90 3.00e-116 411.00
IUUC-Ola-087497 Oryzias latipes 70.30 2.00e-64 239.00
IUUC-Oga-088753 Otolemur garnettii 88.69 0.00e+00 757.00
IUUC-Ptr-091391 Pan troglodytes 90.44 0.00e+00 724.00
IUUC-Pan-092553 Papio anubis 90.26 0.00e+00 728.00
IUUC-Pfo-096585 Poecilia formosa 82.68 4.00e-63 236.00
IUUC-Pab-097962 Pongo abelii 90.62 0.00e+00 730.00
IUUC-Pva-102850 Pteropus vampyrus 84.77 0.00e+00 642.00
IUUC-Rno-105216 Rattus norvegicus 97.43 0.00e+00 789.00
IUUC-Sha-107232 Sarcophilus harrisii 78.90 0.00e+00 684.00
IUUC-Ssc-116341 Sus scrofa 87.64 3.00e-92 331.00
IUUC-Tni-120444 Tetraodon nigroviridis 84.25 1.00e-63 237.00
Created Date 25-Jun-2017

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