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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046543
UUCD1 version UUC-HoS-00587
Ensembl Protein ID ENSP00000386548.1
UniProt Accession O95630; B5M0B6; D6W5H7; Q3MJE7; STABP_HUMAN
Genbank Protein ID AAD05037.1; AAX88908.1; EAW99715.1; EAW99716.1; AAH07682.1; AAH65574.1; AAI01468.1; AAI01470.1; ACH57452.1
Protein Name STAM-binding protein; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase
Genbank Nucleotide ID U73522; AC073046; CH471053; CH471053; BC007682; BC065574; BC101467; BC101469; EU927390
Gene Name STAMBP; AMSH
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000124356.15 ENST00000409707.5 ENSP00000386548.1
ENSG00000124356.15 ENST00000536064.1 ENSP00000443502.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Jab_MPN Jab_MPN 24151880
Classification
Family E-value Score Start End
UBD/Jab_MPN 1.70e-61 207.7 255 382
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Jab_MPN
   S: 4    evvvlpkrllkkflelsdvkiavavevyGlllgelvkdkevktvvlvpkqlagvgsvqvenvedvfdlldqeGlivlGWiHthpeelkflss 95
            +vv+p+rl+++fl+l+++++a++ve++G+l+g+l+++++++t+vl+pkq+ag++++++en+e++f+++dq+Gli+lGWiHthp++++flss
   Q: 255  RHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSS 346
           59****************************************************************************************** PP
   S: 96   vdvathsslealkkrsvaivsspkfqelsafkltde 131
           vd++th+s+++++++svaiv+spkfqe+++fkltd+
   Q: 347  VDLHTHCSYQMMLPESVAIVCSPKFQETGFFKLTDH 382
           ***********************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
 Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Protein Sequence
(Fasta)
MSDHGDVSLP PEDRVRALSQ LGSAVEVNED IPPRRYFRSG VEIIRMASIY SEEGNIEHAF 60
ILYNKYITLF IEKLPKHRDY KSAVIPEKKD TVKKLKEIAF PKAEELKAEL LKRYTKEYTE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046543|UBD,Jab_MPN|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATAGACAGAC GAACGGGAGT GGGCGGAGCG GGCGCCGGAT GTGACGTTTC CGGAACCTCC 60
GGGTGTCATC CGCGGGGAAA GGTGGGGAAG GGTCCCGGGA ACGTGGTGGG GCAGGGCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046543|UBD,Jab_MPN|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0967--Endosome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
IPR007330--MIT
IPR015063--USP8_dimer
IPR015943--WD40/YVTN_repeat-like_dom
Pfam

PF01398--JAB
PF08969--USP8_dimer
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0032154--C:cleavage furrow
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0019904--F:protein domain specific binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007259--P:JAK-STAT cascade
GO:0000281--P:mitotic cytokinesis
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0014067--P:negative regulation of phosphatidylinositol 3-kinase signaling
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0008284--P:positive regulation of cell proliferation
GO:0016579--P:protein deubiquitination
KEGG hsa:10617
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001743 Ailuropoda melanoleuca 92.69 0.00e+00 689.00
IUUC-Atr-002473 Amborella trichopoda 44.50 1.00e-44 174.00
IUUC-Apl-003743 Anas platyrhynchos 75.88 0.00e+00 630.00
IUUC-Aca-005310 Anolis carolinensis 71.43 2.00e-157 548.00
IUUC-Aly-005808 Arabidopsis lyrata 52.54 9.00e-47 181.00
IUUC-Afl-008565 Aspergillus flavus 54.67 3.00e-42 166.00
IUUC-Ani-009164 Aspergillus nidulans 54.67 5.00e-43 169.00
IUUC-Aor-010102 Aspergillus oryzae 54.67 3.00e-42 166.00
IUUC-Ate-010360 Aspergillus terreus 55.41 2.00e-43 170.00
IUUC-Ame-011255 Astyanax mexicanus 60.51 3.00e-146 511.00
IUUC-Bta-012791 Bos taurus 91.95 0.00e+00 686.00
IUUC-Bol-015371 Brassica oleracea 52.49 1.00e-46 181.00
IUUC-Bra-017428 Brassica rapa 52.49 2.00e-46 180.00
IUUC-Cja-019600 Callithrix jacchus 98.11 0.00e+00 733.00
IUUC-Cfa-020125 Canis familiaris 80.84 5.00e-177 613.00
IUUC-Cpo-021625 Cavia porcellus 95.28 0.00e+00 758.00
IUUC-Csa-023635 Chlorocebus sabaeus 99.06 0.00e+00 765.00
IUUC-Cho-024997 Choloepus hoffmanni 76.65 5.00e-163 567.00
IUUC-Cin-025539 Ciona intestinalis 53.54 1.00e-54 207.00
IUUC-Csv-026138 Ciona savignyi 46.25 1.00e-54 207.00
IUUC-Dre-027611 Danio rerio 63.76 6.00e-143 500.00
IUUC-Dno-028859 Dasypus novemcinctus 95.99 0.00e+00 732.00
IUUC-Ete-032412 Echinops telfairi 79.95 6.00e-177 613.00
IUUC-Eca-033504 Equus caballus 95.05 0.00e+00 697.00
IUUC-Eeu-034539 Erinaceus europaeus 93.73 1.00e-158 552.00
IUUC-Fca-035810 Felis catus 95.28 0.00e+00 726.00
IUUC-Fal-037001 Ficedula albicollis 72.19 3.00e-142 498.00
IUUC-Fox-037879 Fusarium oxysporum 50.59 5.00e-41 162.00
IUUC-Fso-038095 Fusarium solani 53.28 2.00e-37 150.00
IUUC-Gmo-038927 Gadus morhua 70.83 4.00e-84 305.00
IUUC-Ggr-039788 Gaeumannomyces graminis 45.30 6.00e-39 155.00
IUUC-Gac-041538 Gasterosteus aculeatus 61.65 4.00e-151 527.00
IUUC-Gma-042650 Glycine max 47.89 1.00e-45 177.00
IUUC-Ggo-045287 Gorilla gorilla 99.53 0.00e+00 770.00
IUUC-Hvu-047336 Hordeum vulgare 56.31 9.00e-31 127.00
IUUC-Itr-048682 Ictidomys tridecemlineatus 96.46 0.00e+00 748.00
IUUC-Lch-049666 Latimeria chalumnae 60.45 1.00e-143 503.00
IUUC-Lpe-051096 Leersia perrieri 45.33 4.00e-45 176.00
IUUC-Loc-052848 Lepisosteus oculatus 64.49 8.00e-130 456.00
IUUC-Lma-053221 Leptosphaeria maculans 50.00 1.00e-41 165.00
IUUC-Laf-053773 Loxodonta africana 95.52 0.00e+00 713.00
IUUC-Mcc-055868 Macaca mulatta 99.06 0.00e+00 765.00
IUUC-Meu-056009 Macropus eugenii 83.14 0.00e+00 640.00
IUUC-Mor-057282 Magnaporthe oryzae 45.30 8.00e-39 155.00
IUUC-Mpo-057473 Magnaporthe poae 45.30 4.00e-39 156.00
IUUC-Mtr-058598 Medicago truncatula 41.60 2.00e-45 177.00
IUUC-Mla-058952 Melampsora laricipopulina 47.22 3.00e-10 56.20
IUUC-Mga-059613 Meleagris gallopavo 74.24 0.00e+00 629.00
IUUC-Mdo-062377 Monodelphis domestica 82.23 3.00e-96 345.00
IUUC-Mmu-063182 Mus musculus 83.49 0.00e+00 645.00
IUUC-Mac-065426 Musa acuminata 42.06 1.00e-45 177.00
IUUC-Mlu-067130 Myotis lucifugus 90.80 0.00e+00 745.00
IUUC-Ncr-068670 Neurospora crassa 49.38 4.00e-38 152.00
IUUC-Nle-069588 Nomascus leucogenys 99.06 0.00e+00 763.00
IUUC-Ont-072010 Oreochromis niloticus 63.13 2.00e-145 508.00
IUUC-Ocu-073794 Oryctolagus cuniculus 96.23 0.00e+00 707.00
IUUC-Oga-088669 Otolemur garnettii 96.23 0.00e+00 735.00
IUUC-Oar-089535 Ovis aries 92.44 0.00e+00 690.00
IUUC-Ptr-090610 Pan troglodytes 99.53 0.00e+00 769.00
IUUC-Pan-091821 Papio anubis 92.40 0.00e+00 688.00
IUUC-Psi-093278 Pelodiscus sinensis 75.18 1.00e-161 562.00
IUUC-Pma-094125 Petromyzon marinus 55.16 1.00e-112 400.00
IUUC-Pno-094896 Phaeosphaeria nodorum 48.55 6.00e-41 162.00
IUUC-Ppa-095880 Physcomitrella patens 48.04 1.00e-45 177.00
IUUC-Pfo-096766 Poecilia formosa 63.47 3.00e-154 538.00
IUUC-Pab-097770 Pongo abelii 99.53 0.00e+00 768.00
IUUC-Pop-098795 Populus trichocarpa 47.18 9.00e-47 181.00
IUUC-Pca-100291 Procavia capensis 77.56 4.00e-165 574.00
IUUC-Ppe-101461 Prunus persica 43.89 2.00e-46 179.00
IUUC-Pva-102762 Pteropus vampyrus 95.99 0.00e+00 734.00
IUUC-Pgr-103491 Puccinia graminis 47.95 3.00e-36 146.00
IUUC-Ptt-103871 Puccinia triticina 50.99 2.00e-34 140.00
IUUC-Pte-104295 Pyrenophora teres 54.90 1.00e-41 164.00
IUUC-Pyt-104611 Pyrenophora triticirepentis 54.90 8.00e-42 165.00
IUUC-Rno-104828 Rattus norvegicus 84.20 0.00e+00 649.00
IUUC-Sha-107440 Sarcophilus harrisii 82.08 2.00e-171 595.00
IUUC-Spo-108166 Schizosaccharomyces pombe 54.55 1.00e-44 174.00
IUUC-Smo-109437 Selaginella moellendorffii 50.60 6.00e-42 163.00
IUUC-Sly-111040 Solanum lycopersicum 45.89 6.00e-46 178.00
IUUC-Stu-112649 Solanum tuberosum 43.44 9.00e-46 177.00
IUUC-Sar-113000 Sorex araneus 78.21 2.00e-114 405.00
IUUC-Ssc-116248 Sus scrofa 94.58 0.00e+00 703.00
IUUC-Tgu-117057 Taeniopygia guttata 67.66 7.00e-143 500.00
IUUC-Tru-118459 Takifugu rubripes 64.34 3.00e-149 521.00
IUUC-Tsy-119283 Tarsius syrichta 83.74 0.00e+00 641.00
IUUC-Tni-120745 Tetraodon nigroviridis 63.66 2.00e-148 518.00
IUUC-Tca-121398 Theobroma cacao 32.74 5.00e-54 205.00
IUUC-Tre-121910 Trichoderma reesei 49.64 1.00e-36 147.00
IUUC-Tvi-122647 Trichoderma virens 50.36 5.00e-37 149.00
IUUC-Tae-124048 Triticum aestivum 44.14 8.00e-44 171.00
IUUC-Tbe-128135 Tupaia belangeri 93.93 2.00e-97 349.00
IUUC-Ttr-129114 Tursiops truncatus 92.12 0.00e+00 671.00
IUUC-Vvi-131419 Vitis vinifera 43.95 1.00e-47 184.00
Created Date 25-Jun-2017

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