iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107431

Ensembl Protein ID

ENSSHAP00000004216.1

UniProt Accession

G3VM11; G3VM11_SARHA

Genbank Protein ID

ENSSHAP00000004216

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AEFK01204306

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000003715.1	ENSSHAT00000004258.1	ENSSHAP00000004216.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.70e-29	100.0	272	322

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 1    ekvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrsk 54
           +kvC  C+++ged+ ++++Ce C++ +H  Clk++  ++lp ++ w C+ Cr +
   Q: 272  CKVCQTCRQPGEDS-MMLVCEACDKGYHTFCLKPA-IQSLPPDS-WKCKTCRVC 322
           589*********76.9*******************.66666665.******965 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MDDPKPSGED KDSEPAADGP EASEESGPTE PDPPNPPLGD ASVHSPGSSK SQDPPQDCSK 60
GPLRRCAFCN CGEWSLHGQR ELRCFKLPPD WPQGSARPPE GPGLGEAVPL NDDLSQIGFP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNTTT TGGGACCGAG GGCAGAGGAC CAACTCCCAG CCTTGGTGTT TTCATCCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR014710--RmlC-like_jellyroll
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001806	Ailuropoda melanoleuca	78.55	0.00e+00	3080.00
IUUC-Aca-005364	Anolis carolinensis	50.99	0.00e+00	1211.00
IUUC-Ame-010612	Astyanax mexicanus	81.00	0.00e+00	981.00
IUUC-Bta-013011	Bos taurus	80.53	0.00e+00	2588.00
IUUC-Cja-019841	Callithrix jacchus	80.08	0.00e+00	3071.00
IUUC-Cfa-021131	Canis familiaris	80.31	0.00e+00	2628.00
IUUC-Cpo-021957	Cavia porcellus	79.44	0.00e+00	3189.00
IUUC-Csa-023722	Chlorocebus sabaeus	81.05	0.00e+00	3031.00
IUUC-Dno-029932	Dasypus novemcinctus	73.73	0.00e+00	1923.00
IUUC-Dor-030192	Dipodomys ordii	81.52	0.00e+00	1427.00
IUUC-Ete-032572	Echinops telfairi	74.53	0.00e+00	1652.00
IUUC-Eca-034166	Equus caballus	85.75	8.00e-165	573.00
IUUC-Eeu-034848	Erinaceus europaeus	85.30	0.00e+00	1211.00
IUUC-Fca-035424	Felis catus	79.69	0.00e+00	3110.00
IUUC-Fal-037179	Ficedula albicollis	66.48	0.00e+00	1164.00
IUUC-Gmo-038719	Gadus morhua	81.82	0.00e+00	900.00
IUUC-Gga-040815	Gallus gallus	56.68	0.00e+00	1510.00
IUUC-Gac-042436	Gasterosteus aculeatus	79.68	0.00e+00	966.00
IUUC-Ggo-044711	Gorilla gorilla	79.68	0.00e+00	3058.00
IUUC-Hsa-046567	Homo sapiens	79.64	0.00e+00	3039.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	78.30	0.00e+00	3084.00
IUUC-Loc-051979	Lepisosteus oculatus	83.33	0.00e+00	1032.00
IUUC-Laf-054377	Loxodonta africana	77.17	0.00e+00	3040.00
IUUC-Mcc-055577	Macaca mulatta	78.56	0.00e+00	2997.00
IUUC-Meu-055992	Macropus eugenii	93.94	0.00e+00	1585.00
IUUC-Mmr-061772	Microcebus murinus	76.17	0.00e+00	3093.00
IUUC-Mdo-062876	Monodelphis domestica	93.50	0.00e+00	1398.00
IUUC-Mmu-063903	Mus musculus	77.66	0.00e+00	2975.00
IUUC-Mpu-066700	Mustela putorius furo	80.01	0.00e+00	3049.00
IUUC-Mlu-068180	Myotis lucifugus	78.48	0.00e+00	3198.00
IUUC-Nle-069362	Nomascus leucogenys	79.65	0.00e+00	3058.00
IUUC-Opr-070304	Ochotona princeps	76.57	0.00e+00	2936.00
IUUC-Ont-071881	Oreochromis niloticus	64.93	0.00e+00	1356.00
IUUC-Oan-073663	Ornithorhynchus anatinus	92.93	0.00e+00	905.00
IUUC-Ocu-074053	Oryctolagus cuniculus	74.59	0.00e+00	3903.00
IUUC-Ola-086384	Oryzias latipes	80.75	0.00e+00	983.00
IUUC-Oga-088450	Otolemur garnettii	78.27	0.00e+00	3287.00
IUUC-Oar-089975	Ovis aries	79.58	0.00e+00	1466.00
IUUC-Ptr-091073	Pan troglodytes	79.38	0.00e+00	2626.00
IUUC-Pan-092871	Papio anubis	78.81	0.00e+00	2636.00
IUUC-Pfo-097525	Poecilia formosa	80.48	0.00e+00	966.00
IUUC-Pab-097679	Pongo abelii	79.70	0.00e+00	3100.00
IUUC-Pca-100499	Procavia capensis	75.18	0.00e+00	2912.00
IUUC-Pva-102898	Pteropus vampyrus	80.33	0.00e+00	3009.00
IUUC-Rno-105660	Rattus norvegicus	77.73	0.00e+00	3081.00
IUUC-Ssc-115678	Sus scrofa	78.81	0.00e+00	3004.00
IUUC-Tru-117922	Takifugu rubripes	80.39	0.00e+00	983.00
IUUC-Tsy-118905	Tarsius syrichta	72.36	0.00e+00	1339.00
IUUC-Tbe-127625	Tupaia belangeri	90.76	5.00e-134	474.00
IUUC-Ttr-129162	Tursiops truncatus	79.25	0.00e+00	1793.00
IUUC-Xtr-132455	Xenopus tropicalis	64.91	0.00e+00	1297.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence